scholarly journals Radiotherapy in Merkel cell carcinoma of facial skin with lymph node recurrence

2020 ◽  
pp. 1-3
Author(s):  
Soo Jung Gong ◽  
Su Jung Shim
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Radiation Treatment ◽  
Neuroendocrine Tumour ◽  
The Elderly ◽  
Left Cheek ◽  
Merkel Cell ◽  
Facial Skin ◽  
Radical Radiation

Abstract Introduction: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumour. Although surgical resection is a treatment choice, it often occurs in the head and neck and occurs mainly in the elderly, making surgery impossible. Radical radiation therapy may be an alternative to surgery in these patients. In addition, radiation treatment may be performed even after recurrence after surgery. Methods: An 82-year-old MCC patient had cT2N0M0, stage IIA MCC on the left cheek that metastasised to lymph node 2 months after surgery. She was treated with radiation monotherapy with a hypofractionation schedule (39 Gy at 3 Gy per fraction). Results: The patient achieved complete remission after radiotherapy without severe toxicities.

Merkel Cell Carcinoma of the Eyelid: A Case Report

2000 ◽  
Vol 10 (2) ◽  
pp. 173-176 ◽  
Author(s):  
L. Collaço ◽  
J.P. Silva ◽  
M. Gonçalves ◽  
P. Abrantes
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
The Elderly ◽  
Primary Site ◽  
Wide Resection ◽  
Merkel Cell ◽  
Unique Case ◽  
Upper Eyelid

A 22-year-old woman who presented with a tumour of the upper eyelid with clinical, histological, immunohistochemical and ultrastructural features of a Merkel cell carcinoma is reported. This is a unique case of Merkel cell carcinoma in such a young patient. This neuroendocrine tumour is typically found in the elderly. It can grow rapidly, has the potential for local recurrence and early metastatic spread. The authors recommend wide resection of the primary site, which proved effective in this case.

scholarly journals Immunotherapy with imiquimod and interferon alfa for metastasized Merkel cell carcinoma

2016 ◽  
Vol 23 (2) ◽  
pp. 150 ◽  
Author(s):  
R.U. Wahl ◽  
T. Braunschweig ◽  
A. Ghassemi ◽  
A. Rübben
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Neuroendocrine Tumour ◽  
Regional Lymph Node ◽  
Pegylated Interferon ◽  
Interferon Alfa ◽  
Merkel Cell ◽  
Node Metastases

Merkel cell carcinoma (mcc) is a highly aggressive neuroendocrine tumour of the skin. Remission rates are high with chemotherapy in patients with metastasis, but without any improvement in overall survival.We present the case of a 90-year-old woman with facial mcc. After radiation and surgery, the mcc recurred with widespread cutaneous and regional lymph node metastases. The metastases were treated with weekly intralesional injections of 1–2×106 IU interferon alfa-2a, accompanied by topical imiquimod 5% cream 3 times weekly. After partial regression, subcutaneous pegylated interferon alfa-2b was added at a dose of 30 μg weekly, which was then increased to 50 μg weekly. At 4 months after the start of immunotherapy, all cutaneous metastases and the intralesionally treated lymph node metastases receded. Interruption or reduction of systemic interferon application resulted in locoregional relapses that were successfully treated with surgery or intralesional interferon injections. The patient remains alive 30 months after initiation of immunotherapy, suggesting that locally metastasized mcc might be able to be controlled with local and systemic immunotherapy.

A Case of Nasal Merkel Cell Carcinoma Draining to a Buccinator Sentinel Lymph Node

2016 ◽  
Vol 41 (11) ◽  
pp. e480-e481 ◽  
Author(s):  
Mohammed S. Bermo ◽  
Alan Leung ◽  
Fatemeh Behnia
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

scholarly journals Merkel cell carcinoma of lymph node with unknown primary has a significantly lower association with Merkel cell polyomavirus than its cutaneous counterpart

2014 ◽  
Vol 27 (9) ◽  
pp. 1182-1192 ◽  
Author(s):  
Zenggang Pan ◽  
Yuan-Yuan Chen ◽  
Xiaojun Wu ◽  
Vijay Trisal ◽  
Sharon P Wilczynski ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell Polyomavirus ◽  
Unknown Primary ◽  
Merkel Cell

scholarly journals Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Eric P. Arruda ◽  
Kevin M. Higgins
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neck Region ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
Treatment Protocols ◽  
Node Biopsy

Merkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. Other etiological factors include immune suppression, organ transplantation, and polyoma virus infection. MCC has a propensity to spread to regional lymphatics with a high locoregional recurrence rate. Since its discovery in 1972, treatment paradigms have shifted, with no consensus on optimal management strategies. Currently, standard of care includes surgical intervention to the primary and locoregional site with adjuvant radiotherapy for high-risk disease. In this paper, we discuss the history, pathology, and epidemiology of this rare disease with a focus on the evidentiary basis of treatment protocols. The use of sentinel lymph node biopsy as a management option will be the focus of this paper.

Merkel Cell Carcinoma

2003 ◽  
Vol 127 (3) ◽  
pp. 367-369 ◽  
Author(s):  
Michael O. Idowu ◽  
Melissa Contos ◽  
Satinder Gill ◽  
Celeste Powers
Keyword(s):  
Gastrointestinal Bleeding ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Upper Gastrointestinal Bleeding ◽  
Neuroendocrine Differentiation ◽  
Neck Region ◽  
The Elderly ◽  
Merkel Cell ◽  
First Case ◽  
Upper Gastrointestinal

Abstract Merkel cell carcinoma (MCC) is an uncommon, highly aggressive cutaneous neoplasm of neuroendocrine differentiation with a poor prognosis. MCC most often presents as a painless, firm, raised lesion in sun-exposed sites of the head and neck region of the elderly. We report a case of a metastatic MCC to the stomach presenting as upper gastrointestinal bleeding. To our knowledge, this is the second reported case of MCC presenting as upper gastrointestinal bleeding and the first case confirmed by the newer immunohistochemical techniques. The literature is reviewed.

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