scholarly journals Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene–environment rat model of depression

2008 ◽  
Vol 12 (04) ◽  
pp. 553 ◽  
Author(s):  
Ben Ryan ◽  
Laura Musazzi ◽  
Alessandra Mallei ◽  
Daniela Tardito ◽  
Suzanne H. M. Gruber ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Rat Model ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Gene Environment

Early-life stress and antidepressants modulate peripheral biomarkers in a gene–environment rat model of depression

2010 ◽  
Vol 34 (6) ◽  
pp. 1037-1048 ◽  
Author(s):  
Lucia Carboni ◽  
Serena Becchi ◽  
Chiara Piubelli ◽  
Alessandra Mallei ◽  
Roberto Giambelli ◽  
...  
Keyword(s):  
Rat Model ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Gene Environment

Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression

2010 ◽  
Vol 44 (8) ◽  
pp. 511-520 ◽  
Author(s):  
Laura Musazzi ◽  
Alessandra Mallei ◽  
Daniela Tardito ◽  
Susanne H.M. Gruber ◽  
Aram El Khoury ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Antidepressant Treatment ◽  
Early Life Stress ◽  
Synaptic Signaling ◽  
Environment Model ◽  
Gene Environment

scholarly journals It Is All in the Right Amygdala: Increased Synaptic Plasticity and Perineuronal Nets in Male, But Not Female, Juvenile Rat Pups after Exposure to Early-Life Stress

2020 ◽  
Vol 40 (43) ◽  
pp. 8276-8291 ◽  
Author(s):  
Angela Guadagno ◽  
Silvanna Verlezza ◽  
Hong Long ◽  
Tak Pan Wong ◽  
Claire-Dominique Walker
Keyword(s):  
Synaptic Plasticity ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Perineuronal Nets ◽  
Rat Pups ◽  
The Right

Transgenerational Transmission of Stress Pathology

2015 ◽  
Vol 223 (3) ◽  
pp. 181-191 ◽  
Author(s):  
Margarete Bolten
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Long Term Outcomes ◽  
Gene Environment ◽  
Stressful Experiences ◽  
Rats And Mice ◽  
The Impact ◽  
Identical Gene

Abstract. The impact of the environment early in life on long-term outcomes is well known. Stressful experiences during pre- and postnatal development can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Furthermore, there is documented evidence for gene-environment interactions in the context of early-life stress. Identical gene variants can be associated with different phenotypes depending on environmental factors. DNA methylation, an enzymatically-catalyzed modification of the DNA, is the mechanism through which phenotypes are regulated. The dynamics and plasticity of epigenetic mechanisms can have short-term, long-term, or transgenerational consequences. In epigenetic research, rodent models have targeted several behavioral and emotional phenotypes. These models have contributed significantly to our understanding of the environmental regulation of the developmental brain in early life. This review will highlight studies with rats and mice on epigenetic processes in fetal programming of stress-related mental disorders.

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