Effect of omeprazole and ranitidine on total carbon dioxide concentration in horses subjected to a simulated race test

2009 ◽  
Vol 6 (02) ◽  
pp. 81 ◽  
Author(s):  
Denise Ciolino ◽  
Robert A Lehnhard ◽  
Kenneth H McKeever
2013 ◽  
Vol 74 (8) ◽  
pp. 1091-1102
Author(s):  
Peter D. Constable ◽  
Stacy H. Tinkler ◽  
Laurent. L. Couëtil

2020 ◽  
Vol 39 (4) ◽  
pp. 441-450
Author(s):  
Keiji Hirai ◽  
Susumu Ookawara ◽  
Junki Morino ◽  
Saori Minato ◽  
Shohei Kaneko ◽  
...  

Author(s):  
Nader Rifai ◽  
John Hyde ◽  
Mariet Iosefsohn ◽  
Allen M. Glasgow ◽  
Steven J Soldin

A significant discrepancy was noted in our laboratory between the total plasma carbon dioxide concentration measured by the Kodak Ektachem 700 and the bicarbonate concentration derived from the Corning 170 pH/Blood Gas analyser in an 8-day-old patient. The concentration of total carbon dioxide was 18 mmol/L while the derived bicarbonate was 13 mmol/L. The patient was eventually diagnosed as maple syrup urine disease. This finding led us to examine the effect of various organic acids on the measurement of carbon dioxide by the Ektachem 700. Several interfered significantly. Clinicians should be aware that when organic acid concentrations are increased, the Ektachem 700 total carbon dioxide result may be falsely raised.


2010 ◽  
Vol 183 (2) ◽  
pp. 191-195 ◽  
Author(s):  
T.J. Caltabilota ◽  
J.G. Milizio ◽  
S. Malone ◽  
J.D. Kenney ◽  
K.H. McKeever

1991 ◽  
Vol 159 (1) ◽  
pp. 371-385
Author(s):  
B. L. Tufts

Exhaustive exercise in cannulated sea lampreys, Petromyzon marinus, resulted in a marked extracellular acidosis in the arterial blood which had both a respiratory and a metabolic component. Blood CO2 tension (PCO2) returned to control levels within an hour after exercise, but the metabolic acidosis had a somewhat longer time course and the extracellular pH (pHe) did not fully recover until the 4 h recovery sample. The magnitude and duration of the changes in both the plasma lactate concentration and the concentration of metabolic protons were very similar and the maximal proton deficit after exercise was, therefore, only 1.5 mequiv l-1. In contrast to the changes in pHe, there were no significant changes in the erythrocyte pH (pHi) following the exercise period. The regulation of pHi was apparently not adrenergically mediated, however, since addition of catecholamines to lamprey blood in vitro had no significant effect on pHi. In addition, the period of exhaustive exercise in vivo was not associated with any significant changes in the mean cellular hemoglobin concentration. The total carbon dioxide concentration in the arterial whole blood and true plasma were both significantly reduced after exercise, but the total carbon dioxide concentration within the erythrocytes was transiently increased. Finally, there was a marked decrease in the arterial PO2 immediately after exercise, which was associated with a significant reduction in the amount of oxygen bound to hemoglobin; however, within 30 min, these values had both returned to normal. The maintenance of pHi presumably contributes to the regulation of oxygen transport in lampreys and it may be particularly important during the brief period immediately after exercise when oxygen transport is clearly compromised. Although several studies have provided evidence that chloride/bicarbonate exchange limitations may exist in agnathan blood in vitro, the present results demonstrate that the characteristics of carbon dioxide transport and acid-base regulation after exercise in P. marinus are not markedly different from those in other lower vertebrates.


1960 ◽  
Vol 37 (3) ◽  
pp. 444-460
Author(s):  
T. R. MILBURN ◽  
L. C. BEADLE

1. The method described involves extraction of the dissolved gas from an acidified sample in a modified van Slyke apparatus, and measurement of the electrical resistance of a standard sodium hydroxide solution before and after equilibration with the extracted gas. 2. The original sample must be not less than about 30 ml. for which a 10 ml. sample is drawn into the extraction apparatus. 3. There is a linear relation between the resistance finally measured and the total carbon dioxide content of the original sample up to a maximum determined by the strength of the standard hydroxide solution, which is thus adjusted to the desired range of carbon dioxide concentration, e.g. 0.005N-NaOH for 0-50 mg./l. and 0.02N for 0-200 mg./l. CO2. 4. The method is easily sensitive to 0.3 mg./l. in the range 0-50 mg./l. total carbon dioxide and about 1 mg./l. in the range 0-200 mg./l. With a rigidly standardized procedure increased accuracy was obtained so that replicate determinations on standard solutions in the 0-50 mg./l. range did not differ by more than 0.16 mg./l. 5. Precautions for handling samples containing carbon dioxide in solution prior to determination have been suggested. 6. About 15-20 min. are required for each determination and to Mrs D. E.


1965 ◽  
Vol 208 (6) ◽  
pp. 1171-1176 ◽  
Author(s):  
S. S. Rothman ◽  
F. P. Brooks

A technic has been developed permitting direct collection of undiluted rabbit pancreatic secretion in vitro without vascular perfusion. The rates of secretion and output of electrolytes were comparable to those obtained in situ. When secretin was added, flow and bicarbonate concentration increased. Secretion in vitro ceased when inhibitors of glycolysis and aerobic metabolism were added to the bathing solution. The sodium concentration of the secretion exceeded that of the bathing solution in all but one observation. Potassium concentrations in secretion were linearly related (slope = 0.93) to the potassium concentration in the bath over a range of 5.8–12.0 mm. After 4–5 hr in vitro, the total carbon dioxide concentration of secretion had decreased while chloride concentration increased with no significant change in the rate of secretion. When secretory rate changed over a range of approximately 30–600 µliters/hr, chloride and carbon dioxide output varied directly with the rate of secretion. The osmolarity of the bathing solution and secretion were always equivalent. These results are incompatible with direct plasma filtration and bicarbonate-chloride exchange as the main mechanisms of pancreatic secretion.


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