scholarly journals Organic Acids Interfere in the Measurement of Carbon Dioxide Concentration by the Kodak Ektachem 700

Author(s):  
Nader Rifai ◽  
John Hyde ◽  
Mariet Iosefsohn ◽  
Allen M. Glasgow ◽  
Steven J Soldin

A significant discrepancy was noted in our laboratory between the total plasma carbon dioxide concentration measured by the Kodak Ektachem 700 and the bicarbonate concentration derived from the Corning 170 pH/Blood Gas analyser in an 8-day-old patient. The concentration of total carbon dioxide was 18 mmol/L while the derived bicarbonate was 13 mmol/L. The patient was eventually diagnosed as maple syrup urine disease. This finding led us to examine the effect of various organic acids on the measurement of carbon dioxide by the Ektachem 700. Several interfered significantly. Clinicians should be aware that when organic acid concentrations are increased, the Ektachem 700 total carbon dioxide result may be falsely raised.

2020 ◽  
Vol 39 (4) ◽  
pp. 441-450
Author(s):  
Keiji Hirai ◽  
Susumu Ookawara ◽  
Junki Morino ◽  
Saori Minato ◽  
Shohei Kaneko ◽  
...  

2020 ◽  
Vol 43 (10) ◽  
pp. 645-652
Author(s):  
John K Leypoldt ◽  
Mauro Pietribiasi ◽  
Anna Ebinger ◽  
Michael A Kraus ◽  
Allan Collins ◽  
...  

Background: The H+ mobilization model has been recently reported to accurately describe intradialytic kinetics of plasma bicarbonate concentration; however, the ability of this model to predict changing bicarbonate kinetics after altering the hemodialysis treatment prescription is unclear. Methods: We considered the H+ mobilization model as a pseudo-one-compartment model and showed theoretically that it can be used to determine the acid generation (or production) rate for hemodialysis patients at steady state. It was then demonstrated how changes in predialytic, intradialytic, and immediate postdialytic plasma bicarbonate (or total carbon dioxide) concentrations can be calculated after altering the hemodialysis treatment prescription. Results: Example calculations showed that the H+ mobilization model when considered as a pseudo-one-compartment model predicted increases or decreases in plasma total carbon dioxide concentrations throughout the entire treatment when the dialysate bicarbonate concentration is increased or decreased, respectively, during conventional thrice weekly hemodialysis treatments. It was further shown that this model allowed prediction of the change in plasma total carbon dioxide concentration after transfer of patients from conventional thrice weekly to daily hemodialysis using both bicarbonate and lactate as dialysate buffer bases. Conclusion: The H+ mobilization model can predict changes in plasma bicarbonate or total carbon dioxide concentration during hemodialysis after altering the hemodialysis treatment prescription.


Author(s):  
G J Van Stekelenburg ◽  
C Valk ◽  
M J G Van Wijngaarden-Penterman

For those clinical laboratories equipped with a microprocessor-controlled gas analyser, an extremely simple method is described for the determination of the total carbon dioxide content in various biological fluids. Since this method needs only 20 μL of blood plasma or is less dependent on the original total carbon dioxide content, it is especially suited for paediatric purposes. With our procedure the time necessary for one determination equals the time for one capillary blood gas analysis.


2013 ◽  
Vol 74 (8) ◽  
pp. 1091-1102
Author(s):  
Peter D. Constable ◽  
Stacy H. Tinkler ◽  
Laurent. L. Couëtil

2010 ◽  
Vol 183 (2) ◽  
pp. 191-195 ◽  
Author(s):  
T.J. Caltabilota ◽  
J.G. Milizio ◽  
S. Malone ◽  
J.D. Kenney ◽  
K.H. McKeever

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2569
Author(s):  
Elena Cristina Scutarașu ◽  
Iulian Valentin Teliban ◽  
Cătălin Ioan Zamfir ◽  
Camelia Elena Luchian ◽  
Lucia Cintia Colibaba ◽  
...  

Organic acids represent naturally occurring compounds that are found in many types of food and beverages, with important functions in defining products’ final quality. Their proportions in wine are dependent on grape composition and winemaking conditions (temperature, pH levels, oxygen, and carbon dioxide concentration). Therefore, this article studied the influence of different fermentation conditions (200 hL tanks vs. 50 L glass demijohns) and various yeasts on the evolution of the main organic acids during alcoholic fermentation of “Aligoté” wines. The fermentation lasted 22 days and samples were collected daily. Laboratory analyses were quantified according to the International Organization of Vine and Wine recommendations. High-performance liquid chromatography for the identification and quantification of organic acids was used. The data showed the important effect of winemaking conditions on sugar consumption, density or acidity values, and sensory characteristics. Significant differences in organic acid concentrations (especially for tartaric acid) were obtained for all variants, depending on the fermentation conditions, inoculated yeast and the sampling moment. The quantities of most of the identified organic acids were generally significantly increased when glass vessels were used, compared to those fermented in tanks. Most organic acids concentrations were favored by lower pH and showed higher values at lower temperatures.


Sign in / Sign up

Export Citation Format

Share Document