Pseudo-Random Mating with Multiple Alleles

2021 ◽  
Vol 24 (4) ◽  
pp. 200-203
Author(s):  
Alan E. Stark
Keyword(s):  
Blood Group ◽  
Stable Equilibrium ◽  
Random Mating ◽  
Abo Blood Group ◽  
Autosomal Locus ◽  
Multiple Alleles ◽  
Nonrandom Mating

AbstractThe conditions on the mating matrix associated with a stable equilibrium are specified for an autosomal locus with four alleles. An example illustrates how Hardy–Weinberg proportions are maintained with nonrandom mating. The ABO blood group provides an illustration.

scholarly journals Deviations from Hardy–Weinberg proportions for multiple alleles under viability selection

2008 ◽  
Vol 90 (2) ◽  
pp. 209-216 ◽  
Author(s):  
GONZALO ALVAREZ
Keyword(s):  
Stable Equilibrium ◽  
Random Mating ◽  
Published Data ◽  
Human Populations ◽  
Autosomal Locus ◽  
Allele Polymorphism ◽  
Multiple Alleles ◽  
Viability Selection ◽  
Genotype Frequencies ◽  
Fixation Indices

SummaryDepartures of genotype frequencies from Hardy–Weinberg proportions (HWP) for a single autosomal locus due to viability selection in a random mating population have been studied only for the two-allele case. In this article, the analysis of deviations from HWP due to constant viability selection is extended to multiple alleles. The deviations for an autosomal locus with k alleles are measured by means of k fii fixation indices for homozygotes and k(k−1)/2 fij fixation indices for heterozygotes, and expressions are obtained for these indices (FIS statistics) under the multiallele viability model. Furthermore, expressions for fii and fij when the multiallele polymorphism is at stable equilibrium are also derived and it is demonstrated that the pattern of multiallele Hardy–Weinberg deviations at equilibrium is characterized by a global heterozygote excess and a deficiency of each of the homozygotes. This pattern may be useful for detecting whether a given multiallelic polymorphism is at stable equilibrium in the population due to viability selection. An analysis of Hardy–Weinberg deviations from published data for the three-allele polymorphism at the β-globin locus in human populations from West Africa is presented for illustration.

scholarly journals Pseudo-random mating populations. In celebration of the 80th anniversary of the Hardy-Weinberg law.

Genetics ◽  
1988 ◽  
Vol 119 (3) ◽  
pp. 731-737
Author(s):  
C C Li
Keyword(s):  
Random Mating ◽  
Sufficient Condition ◽  
Autosomal Locus ◽  
Multiple Alleles ◽  
Nonrandom Mating ◽  
80Th Anniversary ◽  
Basic Case ◽  
Offspring Generation

Abstract That random mating leads to Hardy-Weinberg distribution of genotypes is well known. This report is to show that, if the deviations from random mating are of a certain pattern, the offspring generation will also be in Hardy-Weinberg proportions. This brings out the fact that random mating is a sufficient condition, not a necessary one, for the attainment of the Hardy-Weinberg proportions. Such nonrandom-mating populations are tentatively said to be pseudo-random mating. Pseudo-random-mating populations exist for both autosomal and sex-linked systems with two or multiple alleles. This report covers the basic case of a two-allele autosomal locus in detail, but the possible extension to two loci and cytonuclear systems have also been mentioned in discussion.

The Correlation Between ABO Blood Group and Neonatal Disease Severity

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 461A-461A
Author(s):  
Kacie E. McMahon ◽  
Jonathan K. Muraskas
Keyword(s):  
Disease Severity ◽  
Blood Group ◽  
Abo Blood Group ◽  
Neonatal Disease

A Caution in Association of ABO Blood Group with COVID-19

2020 ◽  
Keyword(s):  
Gene Cluster ◽  
Clinical Outcomes ◽  
Blood Group ◽  
Association Analysis ◽  
Blood Type ◽  
Genome Wide Association ◽  
Chromosome 3 ◽  
Abo Blood Group ◽  
Genome Wide Association Analysis ◽  
Genome Wide

A comment on Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Association of ABO blood group and Covid19 susceptability. medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.03.11.20031096. Zeng X, Fan H, Lu D, Huang F, Meng X, Li Z, et al. Association between ABO blood group and clinical outcomes of Covid19. medRxiv[PREPRINT].2020; https://doi.org/10.1101/2020.04.15.20063107. Zietz M, Tatonetti N. Testing the association between blood type and COVID-19 infection, intubation, and death medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.04.08.20058073. Ellinghaus D, Degenhardt F, Bujanda L, al. e. The ABO blood group and a chromosome 3 gene cluster associate with SRAS-CoV2 respitarory failure in an Italy-Spain genome-wide association analysis. medRxiv. 2020; https://doi.org/10.1101/2020.05.31.20114991.

scholarly journals ABO blood group and COVID‐19: a review on behalf of the ISBT COVID‐19 working group

Vox Sanguinis ◽  
2021 ◽  
Author(s):  
Ruchika Goel ◽  
Evan M. Bloch ◽  
France Pirenne ◽  
Arwa Z. Al‐Riyami ◽  
Elizabeth Crowe ◽  
...  
Keyword(s):  
Blood Group ◽  
Working Group ◽  
Abo Blood Group

scholarly journals ABO Blood Group and the Risk of Pancreatic Cancer

2009 ◽  
Vol 101 (6) ◽  
pp. 424-431 ◽  
Author(s):  
B. M. Wolpin ◽  
A. T. Chan ◽  
P. Hartge ◽  
S. J. Chanock ◽  
P. Kraft ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Blood Group ◽  
Abo Blood Group

Biomimetic ABO Blood-Group Typing

2006 ◽  
Vol 45 (16) ◽  
pp. 2626-2629 ◽  
Author(s):  
Oliver Hayden ◽  
Karl-J. Mann ◽  
Stefan Krassnig ◽  
Franz L. Dickert
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group Typing
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