In Vivo Near-Infrared Spectroscopy of Rat Skin Tissue with Varying Blood Glucose Levels

2006 ◽  
Vol 78 (1) ◽  
pp. 215-223 ◽  
Author(s):  
Jonathon T. Olesberg ◽  
Lingzhi Liu ◽  
Valerie Van Zee ◽  
Mark A. Arnold
Author(s):  
Sachiko Kessoku ◽  
Katsuhiko Maruo ◽  
Shinpei Okawa ◽  
Kazuto Masamoto ◽  
Yukio Yamada

Various non-invasive glucose monitoring methods using near-infrared spectroscopy have been investigated although no method has been successful so far. Our previous study has proposed a new promising method utilizing numerically generated absorbance spectra instead of the experimentally acquired absorbance spectra. The method suggests that the correct estimation of the optical properties is very important for numerically generating the absorbance spectra. The purpose of this study is to measure the change in the optical properties of the skin with the change in the blood glucose level in vivo. By measuring the reflectances of light incident on the skin surface at two distances from the incident point, the optical properties of the skin can be estimated. The estimation is a kind of the inverse problem based on the simulation of light propagation in the skin. Phantom experiments have verified the method and in vivo experiments are to be performed.


2019 ◽  
Vol 9 (11) ◽  
pp. 2366 ◽  
Author(s):  
Laura Di Sieno ◽  
Alberto Dalla Mora ◽  
Alessandro Torricelli ◽  
Lorenzo Spinelli ◽  
Rebecca Re ◽  
...  

In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation.


2012 ◽  
Vol 10 (8) ◽  
pp. 083002-83005 ◽  
Author(s):  
Wanjie Zhang Wanjie Zhang ◽  
Rong Liu Rong Liu ◽  
Wen Zhang Wen Zhang ◽  
Jiaxiang Zheng Jiaxiang Zheng ◽  
Kexin Xu Kexin Xu

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