scholarly journals In Vivo Proton–Electron Double-Resonance Imaging of Extracellular Tumor pH Using an Advanced Nitroxide Probe

2014 ◽  
Vol 86 (2) ◽  
pp. 1045-1052 ◽  
Author(s):  
Alexandre Samouilov ◽  
Olga V. Efimova ◽  
Andrey A. Bobko ◽  
Ziqi Sun ◽  
Sergey Petryakov ◽  
...  
2011 ◽  
Vol 35 (2) ◽  
pp. 471-475 ◽  
Author(s):  
Ziqi Sun ◽  
Haihong Li ◽  
Sergey Petryakov ◽  
Alex Samouilov ◽  
Jay L. Zweier

2018 ◽  
Vol 28 (15) ◽  
pp. 1345-1364 ◽  
Author(s):  
Shun Kishimoto ◽  
Murali C. Krishna ◽  
Valery V. Khramtsov ◽  
Hideo Utsumi ◽  
David J. Lurie

2006 ◽  
Vol 55 (3) ◽  
pp. 669-675 ◽  
Author(s):  
Haihong Li ◽  
Guanglong He ◽  
Yuanmu Deng ◽  
Periannan Kuppusamy ◽  
Jay L. Zweier

2002 ◽  
Vol 48 (3) ◽  
pp. 530-534 ◽  
Author(s):  
Haihong Li ◽  
Yuanmu Deng ◽  
Guanglong He ◽  
Periannan Kuppusamy ◽  
David J. Lurie ◽  
...  

A new technique called proton—electron double-resonance imaging is described for imaging free radicals in aqueous samples. The method is a combination of proton NMR imaging with nuclear electron double resonance. The results of using this technique to image free radicals in vivo in the rat are presented. Rats were injected intravenously with a nitroxide free radical solution and a series of images was obtained from which the clearance of the free radical through the liver and kidneys could be observed.


2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S692-S692
Author(s):  
Mathias Hoehn ◽  
Uwe Himmelreich ◽  
Ralph Weber ◽  
Pedro Ramos-Cabrer ◽  
Susanne Wegener ◽  
...  

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>


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