Liquid chromatography-mass spectrometry. Coupling of a liquid chromatograph to a mass spectrometer

1973 ◽  
Vol 45 (8) ◽  
pp. 1553-1556 ◽  
Author(s):  
R. E. Lovins ◽  
S. R. Ellis ◽  
G. D. Tolbert ◽  
C. R. McKinney
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Mass Spectrometer ◽  
Liquid Chromatography Mass Spectrometry ◽  
Liquid Chromatograph ◽  
Chromatography Mass Spectrometry

scholarly journals Capillary photoionization: interface for low flow rate liquid chromatography-mass spectrometry

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 2867-2871 ◽  
Author(s):  
Päivi Pöhö ◽  
Anu Vaikkinen ◽  
Markus Haapala ◽  
Petri Kylli ◽  
Risto Kostiainen
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Mass Spectrometer ◽  
Flow Rate ◽  
Low Flow ◽  
Liquid Chromatography Mass Spectrometry ◽  
Liquid Chromatograph ◽  
First Report ◽  
Chromatography Mass Spectrometry ◽  
Low Flow Rate

The first report on capillary photoionization interfacing a liquid chromatograph and mass spectrometer.

scholarly journals Analytical procedure for the determination of tetracyclines in medicated feedingstuffs by liquid chromatography-mass spectrometry

2016 ◽  
Vol 60 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Ewelina Patyra ◽  
Krzysztof Kwiatek
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Mass Spectrometer ◽  
Analytical Procedure ◽  
Liquid Chromatography Mass Spectrometry ◽  
Analytical Column ◽  
Mcilvaine Buffer ◽  
Chromatography Mass Spectrometry ◽  
Feed Samples

Abstract Introduction: The article presents a rapid and simple analytical procedure for determination of four tetracyclines (oxytetracycline, tetracycline, chlortetracycline, and doxycycline) in animal medicated feedingstuffs. Material and Methods: Two-gramme samples were extracted by a Na2EDTA-McIlvaine buffer (pH 4)/methanol mixtures (40/60, v/v). The determination was achieved by liquid chromatography using a Zorbax Eclipse XDB C18 analytical column with mass spectrometer detection (LC-MS). Results: Recoveries of the antibiotics from spiked feed samples ranged from 78.2% to 113.5%. The LOD and LOQ for tetracyclines in feeds ranged from 2.8 to 4.2 and from 4.3 to 5.7 mg/kg, respectively. Conclusion: The method was successfully validated and proved to be efficient, precise, and useful for quantification of tetracyclines in medicated feedingstuffs.

scholarly journals Determination of Chlormequat in Pears by Liquid Chromatography/Mass Spectrometry

2000 ◽  
Vol 83 (3) ◽  
pp. 742-747 ◽  
Author(s):  
Hans G J Mol ◽  
Ruud C J Van Dam ◽  
Rob J Vreeken ◽  
Odile M Steijger
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Trap ◽  
Triple Quadrupole ◽  
Liquid Chromatography Mass Spectrometry ◽  
Liquid Chromatograph ◽  
Triple Quadrupole Instrument ◽  
Chromatography Mass Spectrometry ◽  
Quadrupole Instrument

Abstract A straightforward and reliable method was developed for the determination of chlormequat in pears by liquid chromatography/mass spectrometry (LC/MS). Water and methanol were compared as extraction solvents. Because no significant differences in extraction efficiency or repeatability were found, water was chosen as the extraction solvent. The extracts were analyzed without cleanup by either an ion-trap liquid chromatograph/mass spectrometer in the single MS mode or a triple-quadrupole instrument in the MS/MS mode, using electrospray ionization. Both instruments were equally suitable for quantitation and confirmation of identity. Recoveries were 76–103%, and reproducibility was ≤12%. The lowest detection limit (0.007 mg/kg) was obtained with the triple-quadrupole instrument in the MS/MS mode.

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