Detection and Quantification of Silver Nanoparticles at Environmentally Relevant Concentrations Using Asymmetric Flow Field–Flow Fractionation Online with Single Particle Inductively Coupled Plasma Mass Spectrometry

2016 ◽  
Vol 88 (9) ◽  
pp. 4909-4916 ◽  
Author(s):  
Khanh An Huynh ◽  
Emily Siska ◽  
Edward Heithmar ◽  
Soheyl Tadjiki ◽  
Spiros A. Pergantis
Keyword(s):  
Mass Spectrometry ◽  
Silver Nanoparticles ◽  
Flow Field ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Field Flow Fractionation ◽  
Asymmetric Flow ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Detection And Quantification

scholarly journals Challenges in Determining the Size Distribution of Nanoparticles in Consumer Products by Asymmetric Flow Field-Flow Fractionation Coupled to Inductively Coupled Plasma-Mass Spectrometry: The Example of Al2O3, TiO2, and SiO2 Nanoparticles in Toothpaste

Separations ◽  
2018 ◽  
Vol 5 (4) ◽  
pp. 56 ◽  
Author(s):  
Manuel Correia ◽  
Toni Uusimäki ◽  
Allan Philippe ◽  
Katrin Loeschner
Keyword(s):  
Mass Spectrometry ◽  
Particle Size ◽  
Flow Field ◽  
Inductively Coupled Plasma ◽  
Field Flow Fractionation ◽  
Asymmetric Flow ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Flow Fractionation

According to the current European regulation on cosmetics, any ingredient present as a nanomaterial should be indicated in the ingredient list. There is a need for analytical methods capable of determining the size of the relevant ingredients and thus assessing if these are nanomaterials or not. An analytical method based on asymmetric flow field-flow fractionation (AF4) and inductively coupled plasma-mass spectrometry (ICP-MS) was developed to determine the size of particles present in a commercial toothpaste. Multi-angle light scattering (MALS) was used for on-line size determination. The number-based particle size distributions (PSDs) of the particles were retrieved upon mathematical conversion of the mass-based PSDs recovered from the AF4-ICP-MS fractograms. AF4-ICP-MS allowed to separate and detect Al2O3 and TiO2 particles in the toothpaste and to retrieve a correct TiO2 number-based PSD. The potential presence of particles in the lower size range of the Al2O3 mass-based PSD had a strong impact on sizing and nanomaterial classification upon conversion. AF4 coupled with ICP-MS and MALS was found to be a powerful approach for characterization of different particles in a multiple-particle system such as toothpaste. Confirmation of particle size by a secondary method such as single particle ICP-MS or hydrodynamic chromatography was crucial.

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