Toxicity Assessment of Iron Oxide Nanoparticles Based on Cellular Magnetic Loading Using Magnetophoretic Sorting in a Trapezoidal Microchannel

2017 ◽  
Vol 90 (1) ◽  
pp. 920-927 ◽  
Author(s):  
Fengshan Shen ◽  
Je-Kyun Park
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles ◽  
Magnetic Loading ◽  
Trapezoidal Microchannel

scholarly journals In vitro toxicity assessment of chitosan oligosaccharide coated iron oxide nanoparticles

2015 ◽  
Vol 2 ◽  
pp. 27-39 ◽  
Author(s):  
Sudeep Shukla ◽  
Alka Jadaun ◽  
Vikas Arora ◽  
Raj Kumar Sinha ◽  
Neha Biyani ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Toxicity Assessment ◽  
In Vitro Toxicity ◽  
Oxide Nanoparticles ◽  
Chitosan Oligosaccharide ◽  
In Vitro Toxicity Assessment

Toxicity assessment and comparison between two types of iron oxide nanoparticles in Mytilus galloprovincialis

2016 ◽  
Vol 172 ◽  
pp. 9-20 ◽  
Author(s):  
Chrysa Taze ◽  
Ioannis Panetas ◽  
Stavros Kalogiannis ◽  
Konstantinos Feidantsis ◽  
George P. Gallios ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Mytilus Galloprovincialis ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles

scholarly journals In-Vivo Toxicity Assessment of Biologically Synthesized Iron Oxide Nanoparticles in Zebrafish (Danio Rerio)

2018 ◽  
Vol 15 (2) ◽  
pp. 419-425 ◽  
Author(s):  
Shazmin Mohiuddin Hafiz ◽  
Smital Sameer Kulkarni ◽  
Mansee Kapil Thakur
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Developmental Toxicity ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles ◽  
Zebra Fish ◽  
Consumer Market ◽  
Biological Reduction ◽  
The Past

Nanoparticles are increasingly used for biomedical purposes. In the past decades, much attention has been paid to toxicity assessment of nanoparticles prior to clinical and biological applications. Iron oxide nanoparticles (IONPs) are being introduced into the consumer market significantly. Effects and accumulation patterns of IONPs were studied using zebrafish embryos. Nanoparticles of iron were synthesized by biological reduction of spinach, using 0.1 M Ferric Chloride. These nanoparticles were characterized by SEM-EDS, XRD, FTIR and AAS were found to have the size range of 100 to 250 nm. Fish (n=12/group) were exposed from 8hpf to 7dpf to 1, 5, 10, 50 and 100 mg/L IONPs. The results showed that LC50 was found to be10 mg/L concentration of iron oxide nanoparticles. 50 mg/L and 100 mg/L concentrations showed developmental toxicity in these embryos, causing mortality, and hatching delay. This study is one of the first on developmental toxicity in zebra fish caused by using biologically synthesised iron oxide nanoparticles.

scholarly journals Toxicity assessment of superparamagnetic iron oxide nanoparticles in different tissues

2020 ◽  
Vol 48 (1) ◽  
pp. 443-451 ◽  
Author(s):  
Roghayyeh Vakili-Ghartavol ◽  
Amir Abbas Momtazi-Borojeni ◽  
Zeynab Vakili-Ghartavol ◽  
Hammed Tanimowo Aiyelabegan ◽  
Mahmoud Reza Jaafari ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Toxicity Assessment ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Different Tissues

scholarly journals Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85835 ◽  
Author(s):  
Maria Ada Malvindi ◽  
Valeria De Matteis ◽  
Antonio Galeone ◽  
Virgilio Brunetti ◽  
George C. Anyfantis ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Sign in / Sign up

Export Citation Format

Share Document