Controlled Nitric Oxide Release Using Poly(lactic-co-glycolic acid) Nanoparticles for Anti-Inflammatory Effects

2020 ◽  
Vol 21 (12) ◽  
pp. 4972-4979
Author(s):  
Yoogyeong Oh ◽  
Hyejoong Jeong ◽  
Sungmin Lim ◽  
Jinkee Hong
Keyword(s):  
Nitric Oxide ◽  
Glycolic Acid ◽  
Nitric Oxide Release ◽  
Anti Inflammatory

Nitric Oxide Release Is Not Required to Decrease the Ulcerogenic Profile of Nonsteroidal Anti-inflammatory Drugs

2012 ◽  
Vol 55 (2) ◽  
pp. 688-696 ◽  
Author(s):  
Sarthak Jain ◽  
Susan Tran ◽  
Mohamed A. M. El Gendy ◽  
Khosrow Kashfi ◽  
Paul Jurasz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Release ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile

Planta Medica ◽  
2019 ◽  
Vol 85 (11/12) ◽  
pp. 947-956 ◽  
Author(s):  
Mounira Benteldjoune ◽  
Maria Giovanna Chini ◽  
Anna Maria Iannuzzi ◽  
Ahmed Kabouche ◽  
Zahia Kabouche ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cyclooxygenase 2 ◽  
Coupling Constants ◽  
Nitric Oxide Release ◽  
Aerial Parts ◽  
Chemical Shift Data ◽  
Anti Inflammatory ◽  
Inflammatory Profile ◽  
Predicted Values

AbstractIn this paper, the isolation of five new guaianolides (1 – 5) and four (6 – 9) known sesquiterpenes from Ormenis mixta aerial parts is reported. The structural determination of the guaianolides was obtained by NMR spectroscopic data, as well as MS experiments. Their relative configurations were assigned by a combined quantum mechanical/NMR approach, comparing the experimental 13C/1H NMR chemical shift data and 1 J H-H homonuclear coupling constants with the related predicted values. The isolates were assayed for their anti-inflammatory potential evaluating nitric oxide release and cyclooxygenase-2 expression in J774A.1 macrophages treated with lipopolysaccharide from Escherichia coli. Our results indicated that, among the tested compounds, 1 – 3, and 7 were able to inhibit nitric oxide release, while all were able to inhibit cyclooxygenase-2 expression with different potencies.

Sign in / Sign up

Export Citation Format

Share Document