Factors Differentiating the Effectiveness of Polyprotic Acids as Inhibitors of Calcium Oxalate Crystallization in Kidney Stone Disease

2018 ◽  
Vol 18 (9) ◽  
pp. 5617-5627 ◽  
Author(s):  
Jihae Chung ◽  
Michael G. Taylor ◽  
Ignacio Granja ◽  
John R. Asplin ◽  
Giannis Mpourmpakis ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Disease ◽  
Calcium Oxalate Crystallization ◽  
Kidney Stone Disease

A Porcine Model of Calcium Oxalate Kidney Stone Disease

2004 ◽  
Vol 171 (3) ◽  
pp. 1301-1303 ◽  
Author(s):  
NEIL S. MANDEL ◽  
JAMES D. HENDERSON ◽  
LINDA Y. HUNG ◽  
DAVID F. WILLE ◽  
JOHN H. WIESSNER
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Porcine Model ◽  
Stone Disease ◽  
Kidney Stone Disease

Prevalence of Hyperoxaluria in Idiopathic Calcium Oxalate Kidney Stone Disease

Nephron ◽  
1983 ◽  
Vol 35 (1) ◽  
pp. 11-14 ◽  
Author(s):  
B. Baggio ◽  
G. Gambaro ◽  
S. Favaro ◽  
A. Borsatti
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Disease ◽  
Kidney Stone Disease

scholarly journals 40 Years of Oxalobacter formigenes , a Gutsy Oxalate-Degrading Specialist

2021 ◽  
Author(s):  
Steven L. Daniel ◽  
Luke Moradi ◽  
Henry Paiste ◽  
Kyle D. Wood ◽  
Dean G. Assimos ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Critical Role ◽  
Primary Hyperoxaluria ◽  
Severe Form ◽  
Stone Disease ◽  
Future Research ◽  
Oxalobacter Formigenes ◽  
Kidney Stone Disease ◽  
Degrading Bacterium

Oxalobacter formigenes , a unique anaerobic bacterium that relies solely on oxalate for growth, is a key oxalate-degrading bacterium in the mammalian intestinal tract. Degradation of oxalate in the gut by O. formigenes plays a critical role in preventing renal toxicity in animals that feed on oxalate-rich plants. The role of O. formigenes in reducing the risk of calcium oxalate kidney stone disease and oxalate nephropathy in humans is less clear, in part due to difficulties in culturing this organism, and the lack of studies which have utilized diets controlled in their content of oxalate. Herein, we review the literature on the 40 th anniversary of the discovery of O. formigenes , with a focus on its biology, its role in gut oxalate metabolism and calcium oxalate kidney stone disease, and potential areas of future research. Results from ongoing clinical trials utilizing O. formigenes in healthy volunteers and in patients with Primary Hyperoxaluria Type 1 (PH1), a rare but severe form of calcium oxalate kidney stone disease, will also be discussed. Information has been consolidated on O. formigenes strains and best practices to culture this bacterium, which should serve as a good resource for researchers.

Evaluation of the Effect of Moringa peregrina bark on the Crystal Habit and Size of Calcium Oxalate Monohydrate Crystals in Different Stages of Crystallization using Experimental and Theoretical Methods

CrystEngComm ◽  
2021 ◽  
Author(s):  
Sindhu Menon ◽  
Hajar Al Mamari ◽  
Hajar Al Zaabi ◽  
Zainab Al Ajmi ◽  
Laila Al Haddabi ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Significant Proportion ◽  
Calcium Oxalate Monohydrate ◽  
Stone Disease ◽  
Crystal Habit ◽  
Kidney Stone Disease ◽  
Theoretical Methods ◽  
Moringa Peregrina

A significant proportion of the world’s population is afflicted by kidney stone disease, urolithiasis, often as a chronic, recurring condition. The process of biomineralization leading to urolithiasis can be regulated...

scholarly journals Perturbations of the Gut Microbiome and Metabolome in Children with Calcium Oxalate Kidney Stone Disease

2020 ◽  
Vol 31 (6) ◽  
pp. 1358-1369 ◽  
Author(s):  
Michelle R. Denburg ◽  
Kristen Koepsell ◽  
Jung-Jin Lee ◽  
Jeffrey Gerber ◽  
Kyle Bittinger ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stones ◽  
Gut Microbiome ◽  
Early Onset ◽  
Kidney Stone ◽  
Stone Disease ◽  
Metagenomic Sequencing ◽  
Kidney Stone Disease ◽  
Stone Formers ◽  
Age Related

BackgroundThe relationship between the composition and function of gut microbial communities and early-onset calcium oxalate kidney stone disease is unknown.MethodsWe conducted a case-control study of 88 individuals aged 4–18 years, which included 44 individuals with kidney stones containing ≥50% calcium oxalate and 44 controls matched for age, sex, and race. Shotgun metagenomic sequencing and untargeted metabolomics were performed on stool samples.ResultsParticipants who were kidney stone formers had a significantly less diverse gut microbiome compared with controls. Among bacterial taxa with a prevalence >0.1%, 31 taxa were less abundant among individuals with nephrolithiasis. These included seven taxa that produce butyrate and three taxa that degrade oxalate. The lower abundance of these bacteria was reflected in decreased abundance of the gene encoding butyryl-coA dehydrogenase (P=0.02). The relative abundance of these bacteria was correlated with the levels of 18 fecal metabolites, and levels of these metabolites differed in individuals with kidney stones compared with controls. The oxalate-degrading bacterial taxa identified as decreased in those who were kidney stone formers were components of a larger abundance correlation network that included Eggerthella lenta and several Lactobacillus species. The microbial (α) diversity was associated with age of stone onset, first decreasing and then increasing with age. For the individuals who were stone formers, we found the lowest α diversity among individuals who first formed stones at age 9–14 years, whereas controls displayed no age-related differences in diversity.ConclusionsLoss of gut bacteria, particularly loss of those that produce butyrate and degrade oxalate, associates with perturbations of the metabolome that may be upstream determinants of early-onset calcium oxalate kidney stone disease.

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