Surface-induced Dissociation Mass Spectrometry as a Structural Biology Tool

2021 ◽  
Author(s):  
Dalton T. Snyder ◽  
Sophie R. Harvey ◽  
Vicki H. Wysocki
Keyword(s):  
Mass Spectrometry ◽  
Structural Biology ◽  
Surface Induced Dissociation

scholarly journals Mass Spectrometry in Structural Biology: Surface‐induced Dissociation/Ion Mobility of Protein Complexes

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Vicki Wysocki ◽  
Royston Quintyn ◽  
Sophie Harvey ◽  
Yang Song ◽  
Jing Yan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Structural Biology ◽  
Ion Mobility ◽  
Protein Complexes ◽  
Surface Induced Dissociation

scholarly journals Surface-induced dissociation of peptide ions in Fourier-transform mass spectrometry

1990 ◽  
Vol 1 (5) ◽  
pp. 413-416 ◽  
Author(s):  
Evan R. Williams ◽  
Kent D. Henry ◽  
Fred W. McLafferty ◽  
Jeffrey Shabanowitz ◽  
Donald F. Hunt
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Fourier Transform Mass Spectrometry ◽  
Peptide Ions ◽  
Surface Induced Dissociation

scholarly journals Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry

2019 ◽  
Vol 476 (21) ◽  
pp. 3125-3139 ◽  
Author(s):  
Daniel Shiu-Hin Chan ◽  
Jeannine Hess ◽  
Elen Shaw ◽  
Christina Spry ◽  
Robert Starley ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Escherichia Coli ◽  
Structural Biology ◽  
Ion Mobility ◽  
Biosynthetic Pathway ◽  
Screening Tool ◽  
Native Mass Spectrometry ◽  
Ion Mobility Mass Spectrometry ◽  
E Coli ◽  
Structural Insights

Abstract CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility–mass spectrometry to gain structural insights into the phosphopantothenoylcysteine synthetase domain of E. coli CoaBC. Moreover, native mass spectrometry was validated as a screening tool to identify novel inhibitors of this enzyme, highlighting the utility and versatility of this technique both for structural biology and for drug discovery.

scholarly journals Localization of Protein Complex Bound Ligands by Surface-Induced Dissociation High-Resolution Mass Spectrometry

2018 ◽  
Vol 90 (21) ◽  
pp. 12796-12801 ◽  
Author(s):  
Florian Busch ◽  
Zachary L. VanAernum ◽  
Yue Ju ◽  
Jing Yan ◽  
Joshua D. Gilbert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Protein Complex ◽  
High Resolution Mass Spectrometry ◽  
Surface Induced Dissociation ◽  
High Resolution Mass ◽  
Resolution Mass
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