New Horizons in Microbiological Food Safety: Ultraefficient Photodynamic Inactivation Based on a Gallic Acid Derivative and UV-A Light and Its Application with Electrospun Cyclodextrin Nanofibers

2021 ◽  
Author(s):  
Yu-gang Shi ◽  
Chen-min Zhu ◽  
Dong-hui Li ◽  
Ze-yu Shi ◽  
Qing Gu ◽  
...  
Keyword(s):  
Food Safety ◽  
Gallic Acid ◽  
Acid Derivative ◽  
Photodynamic Inactivation ◽  
New Horizons

Characterization and antioxidant activity of gallic acid derivative

2017 ◽  
Author(s):  
Krissan Malinda ◽  
Hery Sutanto ◽  
Akhmad Darmawan
Keyword(s):  
Antioxidant Activity ◽  
Gallic Acid ◽  
Acid Derivative

A gallic acid derivative and polysaccharides with antioxidative activity from rose (Rosa rugosa) flowers

2004 ◽  
Vol 56 (4) ◽  
pp. 537-545 ◽  
Author(s):  
T. B. Ng ◽  
J. S. He ◽  
S. M. Niu ◽  
Z. F. Pi ◽  
W. Shao ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Acid Derivative ◽  
Antioxidative Activity ◽  
Rosa Rugosa

scholarly journals SYNTHESIS AND ANTI-HEPATITIS C VIRUS ACTIVITY OF GALLIC ACID DERIVATIVES WITH CHIRAL CENTER

2017 ◽  
Vol 10 (7) ◽  
pp. 164 ◽  
Author(s):  
Ade Arsianti ◽  
Chie Aoki Utsubo ◽  
Fadilah Fadilah ◽  
Anton Bahtiar ◽  
Dadan Ramadhan Apriyanto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Gallic Acid ◽  
Aromatic Ring ◽  
Acid Derivative ◽  
Allyl Bromide ◽  
Chiral Center ◽  
Hydroxyl Group ◽  
Promising Candidate ◽  
Asymmetric Dihydroxylation

Objective: In this work, we aim to synthesize gallic acid derivatives with chiral center and to evaluate its anti-hepatitis C virus (anti-HCV) activity.Methods: Synthesis of the target derivatives was started from esterification of commercially available boc deprotection (Boc)-L-threonine with allyl bromide, followed by Boc with HCl/EtOAc, amidation, and Sharpless asymmetric dihydroxylation with (DHQ)2PHAL or (DHQD)2PHAL as a ligand to give desired gallic acid derivatives. The synthesized gallic acid derivatives were then evaluated for anti-HCV activity and cytotoxicity.Results: The target derivatives were successfully synthesized in ranging from 20% to 30% of yield. Anti-HCV activity of the derivatives is greatly improved by the presence of chiral center, hydroxyl group, and monomethoxy group on the aromatic ring, with showed no cytotoxicity. This fact revealed that the chiral center, hydroxyl group, and monomethoxy group on the aromatic ring of gallic acid derivatives are responsible for its anti-HCV activity. Moreover, gallic acid derivative which possesses a chiral center of bottom facial stereochemistry was found to have a stronger anti-HCV activity than gallic acid derivative with chiral center of top facial stereochemistry. Suggesting that, bottom facial stereocenter in gallic acid derivative was more effective for anti-HCV activity than the top facial stereocenter.Conclusion: Gallic acid derivatives with chiral center exhibited a greater antiviral activity against HCV than gallic acid. Thus, the derivatives should be considered as a promising candidate for the treatment of HCV infection. 

Threonine-Allyl-Ester and Amide of Gallic Acid Derivative as Promising Anti-HCV Inhibitors

2018 ◽  
Vol 24 (8) ◽  
pp. 6265-6267
Author(s):  
Dadan Ramadhan Apriyanto ◽  
Ade Arsianti ◽  
Chie Aoki-Utsubo ◽  
Fadilah ◽  
Anton Bahtiar ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Gallic Acid ◽  
Acid Derivative ◽  
Allyl Bromide ◽  
Effective Concentration ◽  
Allyl Ester ◽  
Hcv Genotype

In this study, we focused to evaluate threonine-allyl-ester (TAE) and amide of gallic acid derivative (AGA) for anti-HCV activity. The synthesis was started from esterification of commercially available Boc-L-Threonine with allyl bromide, followed by Boc deprotection with HCl/EtOAc produced threonine-allyl-ester (TAE) and amidation of the ester with the gallic acid with WSCD HCl, HOBt, and NMM produced the amide of gallic acid derivative (AGA). The synthesized were examined the antiviral activity against HCV (genotype 2a strain JFH1) and cytotoxicity against Huh7it-1. The synthesized of TAE and AGA were in ranging from 91% to 50% of yield. The TAE and AGA exhibited anti-HCV activity with a 50% effective concentration (EC50) of 24.5 μg/ml and 12.1 μg/ml without cytotoxicity, respectively. These results suggest that TAE and AGA have potential as anti-HCV. Further study, TAE and AGA are synthesized with addition another form.

Effects of ultraviolet light and curcumin-mediated photodynamic inactivation on microbiological food safety: A study in meat and fruit

2020 ◽  
Vol 30 ◽  
pp. 101678 ◽  
Author(s):  
Thaila Quatrini Corrêa ◽  
Kate Cristina Blanco ◽  
Érica Boer Garcia ◽  
Shirly Marleny Lara Perez ◽  
Daniel José Chianfrone ◽  
...  
Keyword(s):  
Food Safety ◽  
Ultraviolet Light ◽  
Photodynamic Inactivation

scholarly journals Trends and targets in antiviral phototherapy

2019 ◽  
Vol 18 (11) ◽  
pp. 2565-2612 ◽  
Author(s):  
Arno Wiehe ◽  
Jessica M. O'Brien ◽  
Mathias O. Senge
Keyword(s):  
Food Safety ◽  
Water Disinfection ◽  
Photodynamic Inactivation ◽  
Blood Products

With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.

scholarly journals Phytochemical Components and Bioactivity Assessment among Twelve Strawberry (Arbutus unedo L.) Genotypes Growing in Morocco Using Chemometrics

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1345 ◽  
Author(s):  
Hafida Zitouni ◽  
Lahcen Hssaini ◽  
Zerhoune Messaoudi ◽  
Hamza Ourradi ◽  
Manuel Viuda-Martos ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Gallic Acid ◽  
Acid Derivative ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Principal Component ◽  
Hydrolyzable Tannins ◽  
Arbutus Unedo ◽  
Strawberry Tree ◽  
Tree Fruits

There are not many exhaustive works emphasizing the amount of genetic diversity among the strawberry tree (Arbutus unedo L.) genotypes in Morocco. This work aims to assess the biochemical composition of strawberry tree fruits, as well as to establish the variation of this composition among them. In this study, total phenols (TP), total flavonoids (TF), condensed tannins (CT) and hydrolyzable tannins (HT), total anthocyanins (TA), and free radical scavenging activity through ABTS were investigated in strawberry tree fruits. Furthermore, qualitative and quantitative analyses of individual phenolic compounds by high-performance liquid chromatography (HPLC) were carried out. Color parameters such as lightness (L*), Chroma (c*), and hue angle (h°) were also investigated. All studied variables showed highly significant differences among all samples with the exception of hydrolyzable tannins and chromatic coordinates. TP varied from 22.63 ± 1.74 to 39.06 ± 2.44 mg GAE/g DW, TF varied from 3.30 ± 0.60 to 8.62 ± 1.10 mg RE/g DW, and TA ranged between 0.12 ± 0.06 and 0.66 ± 0.15 mg cya-3-glu/100 g DW. In addition, CT and HT amounts were in the range of 10.41 ± 1.07–16.08 ± 1.50 mg TAE/g DW and 4.08 ± 2.43–6.34 ± 3.47 TAE/g DW, respectively. Moreover, the IC50 value (ABTS) ranged between 1.75 and 19.58 mg AAE/g DW. 17 phenolic compounds were detected in strawberry tree fruits. Gallocatechol and catechin were the most abundant phenolic compounds. Matrix of correlations revealed significant positive and negative correlations among variables particularly c*, a*, and b*. Principal component analysis (PCA) showed that the first three components formed than 68% of the total inertia. The following variables gallic acid, protocatechuic, gallocatechin, gallic acid derivative, chlorogenic acid, syringic acid, ellagic acid derivative II, L*, and h* were the most involved in the total variance explained. Hierarchical clustering classified samples into one main cluster, with a single branch. The results highlight a high biochemical diversity within studied strawberry genotypes, which is probably more genetically related.

Plicosepalin A, a new antioxidant catechin–gallic acid derivative of inositol from the mistletoe Plicosepalus curviflorus

2016 ◽  
Vol 71 (11-12) ◽  
pp. 375-380 ◽  
Author(s):  
Jihan M. Badr ◽  
Sabrin R.M. Ibrahim ◽  
Dina R. Abou-Hussein
Keyword(s):  
Gallic Acid ◽  
Acid Derivative ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antimicrobial Activities ◽  
Spectroscopic Analyses ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
Diffusion Assay ◽  
C Nmr

Abstract Phytochemical investigation of the semi-parasitic plant, Plicosepalus curviflorus (Loranthaceae) growing in Saudi Arabia resulted in the isolation of a new catechin–gallic acid derivative of inositol, plicosepalin A (1) [(+) catechin-4′-O-(1″-O-galloyl-5″-O-methyl)-myo-inositol], along with seven known compounds: methyl gallate (2), catechin (3), quercetin (4), gallic acid (5), lupeol (6), β-sitosterol (7), and ursolic acid (8). Their structures were elucidated on the basis of spectroscopic analyses, including HRESIMS, ESIMS, 1H and 13C NMR, HSQC, and HMBC, as well as comparison with reported data. The antioxidant and antimicrobial activities of 1 were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the disc diffusion assay, respectively. Compound 1 exhibited potent free radical scavenging activity with an IC50 value of 9.0 ± 0.27 μM. Moreover, significant activities against Staphylococcus aureus and Bacillus subtilis were recorded.

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