Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00449 ◽

2020 ◽

Vol 63 (13) ◽

pp. 7143-7162

Author(s):

Masakazu Atobe ◽

Takayuki Serizawa ◽

Natsumi Yamakawa ◽

Kenichiro Takaba ◽

Yukiko Nagano ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Kinase C ◽

Isoquinoline Derivatives ◽

Merging Strategy

Download Full-text

Modulation of tight junction (TJ) structure by enteroinvasive E. coli (EIEC) is prevented by H2O2 scavengers and protein kinase C(PKC) inhibitors

Gastroenterology ◽

10.1016/s0016-5085(01)83509-5 ◽

2001 ◽

Vol 120 (5) ◽

pp. A705-A705

Author(s):

S RESTALENERT ◽

K BARRETT

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tight Junction ◽

E Coli ◽

Kinase C ◽

Download Full-text

Protein kinase C (PKC)-β1 mediates EGF-induced protection of the microtubule (MT) cytoskeleton & intestinal barrier function (BF) against oxidant injury

Gastroenterology ◽

10.1016/s0016-5085(01)83491-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A701-A701

Author(s):

A BANAN ◽

J FIELDS ◽

Y ZHANG ◽

E MUTLU ◽

A KESHAVARZIAN

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Barrier Function ◽

Intestinal Barrier ◽

Intestinal Barrier Function ◽

Oxidant Injury ◽

Download Full-text

Secretagogue (caerulein)-induced intrapancreatic activation of trypsinogen is mediated by protein kinase C (PKC), phosphoinositide-3-kinases (PI-3Ks) and tyrosine kinases (TKs)

Gastroenterology ◽

10.1016/s0016-5085(01)81674-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A337-A337

Author(s):

V SINGH ◽

A SALUJA ◽

L BHAGAT ◽

G VANACKER ◽

A SONG ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tyrosine Kinases ◽

Download Full-text

Cytokine production in human intestinal mast cells triggered by Fc∈ receptor cross-linking is dependent on both protein kinase C and MAP kinase

Gastroenterology ◽

10.1016/s0016-5085(01)82469-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A497-A497

Author(s):

A LORENTZ ◽

I KLOPP ◽

T GEBHARDT ◽

M MANNS ◽

S BISCHOFF

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Cytokine Production ◽

Fc Receptor ◽

Cross Linking ◽

Download Full-text

Tissue-specific protein kinase C isoform expression in rat uterine tissue

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(99)00035-0 ◽

1999 ◽

Vol 6 (6) ◽

pp. 293-300 ◽

Author(s):

T Kim

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Specific Protein ◽

Uterine Tissue ◽

Tissue Specific ◽

Kinase C ◽

Isoform Expression ◽

Specific Protein Kinase

Download Full-text

876 Human urotensin II activates the sarcolemmal Na+/H+ exchanger: roles of protein kinase C and mitogen-activated protein kinase(s)

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90561-3 ◽

2003 ◽

Vol 2 (1) ◽

pp. 186

Author(s):

K KATO ◽

M YASUTAKE ◽

D JIA ◽

Y KUSAMA ◽

T TAKANO

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Urotensin Ii ◽

Kinase C ◽

Mitogen Activated Protein

Download Full-text

233 Angiotensin II acutely increases diastolic distensibility: a protein kinase C and Na/H exchanger-mediated effect

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(05)80127-4 ◽

2005 ◽

Vol 4 (1) ◽

pp. 48-48

Keyword(s):

Protein Kinase C ◽

Angiotensin Ii ◽

Protein Kinase ◽

Download Full-text

Protein kinase C alpha and epsilon reduce Ca-sensitivity of force development in human myocardium by phosphorylation of troponin

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(08)60143-5 ◽

2008 ◽

Vol 7 ◽

pp. 50-50

Author(s):

J VANDERVELDEN ◽

V KOOIJ ◽

R ZAREMBA ◽

N BOONTJE ◽

G STIENEN

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Human Myocardium ◽

Force Development ◽

Kinase C ◽

Protein Kinase C Alpha ◽

Download Full-text

In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha

Journal of Hepatology ◽

10.1034/j.1600-0641.2000.033004601.x ◽

2000 ◽

Vol 33 (4) ◽

pp. 601-608 ◽

Author(s):

Shwu-Bin Lin ◽

Li-Ching Wu ◽

Siao-Ling Huang ◽

Hui-Lun Hsu ◽

Sung-Hwa Hsieh ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tumor Cells ◽

Rat Liver ◽

Antisense Oligonucleotide ◽

Epithelial Tumor ◽

Kinase C ◽

Epithelial Tumor Cells

Download Full-text

Protein kinase C zeta

AfCS-Nature Molecule Pages ◽

10.1038/mp.a001934.01 ◽

2005 ◽

Author(s):

Jorge Moscat ◽

Maria Diaz-Meco

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Kinase C ◽

Protein Kinase C Zeta

Download Full-text