scholarly journals N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

2020 ◽  
Vol 63 (15) ◽  
pp. 8359-8368
Author(s):  
Jelena Konstantinović ◽  
Samir Yahiaoui ◽  
Alaa Alhayek ◽  
Jörg Haupenthal ◽  
Esther Schönauer ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antivirulence Agents ◽  
Pseudomonas Aeruginosa Elastase

New Strategies Targeting Virulence Factors of Staphylococcus aureus and Pseudomonas aeruginosa

2017 ◽  
Vol 38 (03) ◽  
pp. 346-358 ◽  
Author(s):  
Bruno François ◽  
Charles-Edouard Luyt ◽  
C. Stover ◽  
Jeffery Brubaker ◽  
Jean Chastre ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Virulence Factors ◽  
Effective Utilization ◽  
Mechanically Ventilated ◽  
Stage Of Development ◽  
Antivirulence Agents ◽  
Interventional Therapies ◽  
Improve Patient ◽  
New Strategies

AbstractMorbidity, mortality, and economic burden of nosocomial pneumonia caused by Staphylococcus aureus and Pseudomonas aeruginosa remain high in mechanically ventilated and hospitalized patients despite the use of empirical antibiotic therapy or antibiotics against specific classes of pathogens and procedures to reduce nosocomial infections in hospital settings. Newer agents that neutralize or inhibit specific S. aureus or P. aeruginosa virulence factors may eliminate or reduce the risk for developing pneumonia before or during mechanical ventilation and may improve patient outcomes through mechanisms that differ from those of antibiotics. In this article, we review the types, mechanisms of action, potential advantages, and stage of development of antivirulence agents (AVAs) that hold promise as alternative preventive or interventional therapies against S. aureus– and P. aeruginosa–associated nosocomial pneumonias. We also present and discuss challenges to the effective utilization of AVAs separately from or in addition to antibiotics and the design of clinical trials and meaningful study end points.

scholarly journals Pseudomonas aeruginosa Elastase

1965 ◽  
Vol 240 (8) ◽  
pp. 3295-3304
Author(s):  
Kazuyuki Morihara ◽  
Hiroshige Tsuzuki ◽  
Tatsushi Oka ◽  
Hideo Inoue ◽  
Mitsuo Ebata
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Elastase

scholarly journals Degradation of basement membranes by Pseudomonas aeruginosa elastase.

1989 ◽  
Vol 57 (12) ◽  
pp. 3783-3787 ◽  
Author(s):  
P A Bejarano ◽  
J P Langeveld ◽  
B G Hudson ◽  
M E Noelken
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Basement Membranes ◽  
Pseudomonas Aeruginosa Elastase

Activation of human plasma prekallikrein by Pseudomonas aeruginosa elastase in vitro

1991 ◽  
Vol 1097 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Yoko Shibuya ◽  
Hideaki Tanaka ◽  
Norikazu Nishino ◽  
Hiroaki Okabe ◽  
Takeshi Kambara ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Human Plasma ◽  
Pseudomonas Aeruginosa Elastase
Sign in / Sign up

Export Citation Format

Share Document