Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

2019 ◽  
Vol 62 (17) ◽  
pp. 7739-7750
Author(s):  
Simon Hansen ◽  
Aaron H. Nile ◽  
Shrenik C. Mehta ◽  
Jakob Fuhrmann ◽  
Rami N. Hannoush
Keyword(s):  
Clostridium Difficile ◽  
Epithelial Cells ◽  
Lead Optimization ◽  
Toxin B ◽  
High Affinity ◽  
Clostridium Difficile Toxin ◽  
Clostridium Difficile Toxin B

scholarly journals Yersinia enterocolitica YopT and Clostridium difficile Toxin B Induce Expression of GILZ in Epithelial Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40730 ◽  
Author(s):  
Martin Köberle ◽  
David Göppel ◽  
Tanja Grandl ◽  
Peer Gaentzsch ◽  
Birgit Manncke ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Epithelial Cells ◽  
Yersinia Enterocolitica ◽  
Toxin B ◽  
Clostridium Difficile Toxin ◽  
Clostridium Difficile Toxin B

scholarly journals Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B

FEBS Journal ◽  
2018 ◽  
Vol 286 (5) ◽  
pp. 874-881 ◽  
Author(s):  
Peng Chen ◽  
Liang Tao ◽  
Zheng Liu ◽  
Min Dong ◽  
Rongsheng Jin
Keyword(s):  
Clostridium Difficile ◽  
Wnt Signaling ◽  
Toxin B ◽  
Clostridium Difficile Toxin ◽  
Structural Insight ◽  
Clostridium Difficile Toxin B ◽  
Insight Into

The Effect of Lactoferrin and Pepsin-Treated Lactoferrin on IEC-6 Cell Damage Induced by Clostridium Difficile Toxin B

Shock ◽  
2018 ◽  
Vol 50 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Kosuke Otake ◽  
Norio Sato ◽  
Ayako Kitaguchi ◽  
Takayuki Irahara ◽  
Satoru Murata ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Cell Damage ◽  
Toxin B ◽  
Clostridium Difficile Toxin ◽  
Clostridium Difficile Toxin B

scholarly journals Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage

2015 ◽  
Vol 22 (2) ◽  
pp. 175-185 ◽  
Author(s):  
John Tam ◽  
Greg L. Beilhartz ◽  
Anick Auger ◽  
Pulkit Gupta ◽  
Alex G. Therien ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cellular Damage ◽  
Toxin B ◽  
Clostridium Difficile Toxin ◽  
Clostridium Difficile Toxin B

scholarly journals Inhibition of Receptor Signaling to Phospholipase D by Clostridium difficile Toxin B

1996 ◽  
Vol 271 (5) ◽  
pp. 2422-2426 ◽  
Author(s):  
Martina Schmidt ◽  
Ulrich Rümenapp ◽  
Christine Bienek ◽  
Jutta Keller ◽  
Christoph von Eichel-Streiber ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Phospholipase D ◽  
Receptor Signaling ◽  
Toxin B ◽  
Clostridium Difficile Toxin ◽  
Clostridium Difficile Toxin B
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