Mononitration of a Calix[4]arene Methylene Bridge: Synthesis and Preliminary Catalysis Performances of Bridging Chiral p-tert-Butylcalix[4]arenes with a Monoamino Bridge Substituent in a 1,3-Alternate Conformation

2021 ◽  
Author(s):  
Xin-Bang Peng ◽  
Di He ◽  
Guan-Nan Sun ◽  
Yu Yu ◽  
Ying-Hong Ma ◽  
...  
Keyword(s):  
Methylene Bridge

Cannabisol, a Novel Δ9-THC Dimer Possessing a Unique Methylene Bridge, Isolated from Cannabis sativa

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
F Zulfiqar ◽  
S Ross ◽  
D Slade ◽  
S Ahmed ◽  
MM Radwan ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Methylene Bridge

scholarly journals Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

2009 ◽  
Vol 6 (3) ◽  
pp. 866-870
Author(s):  
CH. Sridevi ◽  
K. Balaji ◽  
A. Naidu ◽  
R. Sudhakaran
Keyword(s):  
Spectral Data ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Methylene Bridge ◽  
Quinoxaline Derivatives ◽  
Antimicrobial Evaluation

2,3-Diphenyl quinoxaline(SI)was fused with 2-amino benzothiazoles(SII)by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones(SV1-SV5). Chalcones refluxed with substituted acid hydrazides to afford different phenyl pyrazolo benzothiazolo quinoxaline derivatives(SVI1-SVI15). The structure of chalcones and phenyl pyrazolo benzothiazolo quinoxaline derivatives were confirmed by M.P, TLC and spectral data. All the synthesized compounds were screened for their antimicrobial activities.

“Methylene Bridge” to 5-HT3 Receptor Antagonists: Conformationally Constrained Phenylguanidines

2018 ◽  
Vol 10 (3) ◽  
pp. 1380-1389 ◽  
Author(s):  
Ahmed S. Abdelkhalek ◽  
Genevieve S. Alley ◽  
Osama I. Alwassil ◽  
Shailesh Khatri ◽  
Philip D. Mosier ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Methylene Bridge ◽  
Conformationally Constrained

scholarly journals Synthesis of 1,1′-methylenebis(1,2,4-triazole) functionalized in the methylene bridge. A new approach to dendrons bearing heterocyclic rings on the periphery

ARKIVOC ◽  
2005 ◽  
Vol 2005 (9) ◽  
pp. 159-164 ◽  
Author(s):  
Enrique Díez-Barra ◽  
Javier Guerra ◽  
Valentín Hornillos ◽  
Sonia Merino ◽  
Julián Rodríguez-López ◽  
...  
Keyword(s):  
New Approach ◽  
Methylene Bridge

Cucurbiturils Substituted on the Methylene Bridge

2014 ◽  
Vol 16 (9) ◽  
pp. 2446-2449 ◽  
Author(s):  
Laura Gilberg ◽  
Muhammad S. A. Khan ◽  
Marketa Enderesova ◽  
Vladimir Sindelar
Keyword(s):  
Methylene Bridge

Methylene bridge regulated geometrical preferences of ligands in cobalt(iii) coordination chemistry and phenoxazinone synthase mimicking activity

2014 ◽  
Vol 43 (14) ◽  
pp. 5443 ◽  
Author(s):  
Anangamohan Panja ◽  
Milan Shyamal ◽  
Amrita Saha ◽  
Tarun Kanti Mandal
Keyword(s):  
Coordination Chemistry ◽  
Methylene Bridge ◽  
Phenoxazinone Synthase

Synthesis of Optically Active 15-epi-9,14-Methylene Lipoxin A4

Synthesis ◽  
2018 ◽  
Vol 50 (06) ◽  
pp. 1246-1258
Author(s):  
Udo Nubbemeyer ◽  
Adile Duymaz ◽  
Jochen Körber ◽  
Carolin Hofmann ◽  
Dorothea Gerlach
Keyword(s):  
Total Synthesis ◽  
Building Block ◽  
Building Blocks ◽  
Optically Active ◽  
Protecting Groups ◽  
Lipoxin A4 ◽  
Methylene Bridge ◽  
Type Coupling ◽  
Important Field ◽  
Gain Access

The synthesis of lipoxin A4 and B4 analogues (LXA4, LXB4) to gain access to stabilized inflammation resolving compounds is an important field of research. Starting from known structural requirements of the natural compounds displaying biological activity and a broad investigation of their rapid metabolism, various LXA4 derivatives have been developed and tested. Focusing on variation and stabilization of the conjugated E,E,Z,E C7–C14 tetraene moiety of natural LXA4, a methylene bridge introduced between C9 and C14 might suppress any Z/E isomerization of the C11–C12 olefin. Intending to enable at least known structure variations in connection with the C1–C7 and the C15–C20 fragments, a convergent total synthesis starting from a known cycloheptatriene is developed. The C1–C8 building blocks are generated via six-step ex-chiral pool sequences starting from 2-deoxy-d-ribose delivering two 5,6-dihydroxy carboxylic acid derivatives with C7 aldehyde functions. The synthesis of the C8–C21 building block starts from a known cycloheptatriene 1-carbonester (C8–C14, C21) and hexanoyl chloride (C15–C20). After Friedel–Crafts-type coupling, the defined configuration of the C15 OH group is introduced via enantioselective reduction of the ketone precursor. Following an additional four steps, an aryl sulfone C9–C21 building block is completed ready for a key Julia–Kocienski olefination with the C1–C7 compounds. Finally, removal of the protecting groups completes the synthesis of the target optically active 9,14-methylene LXA4 methyl ester.

Analogs of cannabinoids: synthesis of some 7H-indolo-, 5H-imidazolo, 7H-benzimidazolo[1,2-c] [1,3]benzoxazines – novel ring systems

1985 ◽  
Vol 63 (3) ◽  
pp. 632-635 ◽  
Author(s):  
V. K. Mahesh ◽  
Mamta Maheswari ◽  
Rakesh Sharma ◽  
Rashmi Sharma
Keyword(s):  
Nitrogen Atom ◽  
Active Compound ◽  
Heterocyclic System ◽  
Phenyl Substituent ◽  
Imino Group ◽  
Active Constituent ◽  
Methylene Bridge ◽  
Ring Systems ◽  
Ring Junction ◽  
System 2

Tetrahydrocannabinol 1, the active constituent of CannabissativaLinn, is a well-known CNS-active compound and introduction of a nitrogen atom at the ring junction of the pyran and alicyclic ring is of considerable interest. This prompted the synthesis of 7H-indolo[1,2-c] [1,3]-, 5H-imidazolo[1,2-C] [1,3],- and 7H-benzimidazolo[1,2-c] [1,3]-benzoxazine, a novel heterocyclic system. 2-(2′-Hydroxyphenyl) indoles, 2-(2′-hydroxyphenyl) imidazoles, and 2-(2′-hydroxyphenyl) benzimidazoles are suitable intermediates for the preparation of this type of benzoxazines, as the second heterocycle (ring B) can then be constructed by introduction of a methylene bridge between the hydroxyl of the 2′-hydroxy phenyl substituent and the imino group of the heterocyclic system.

Preparation of Calix[8]arene Derivatives Functionalized at a Single Methylene Bridge

2011 ◽  
Vol 2011 (32) ◽  
pp. 6581-6585 ◽  
Author(s):  
Norbert Itzhak ◽  
Katerina Kogan ◽  
Silvio E. Biali
Keyword(s):  
Methylene Bridge
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