Nickel-Catalyzed Electrochemical Cyclization of Alkynyl Aryl Iodide and the Domino Reaction with Aldehydes

The reaction between electrophilic benzannulated heterocycles and isoquinolinium methylides results in a domino dipolar cycloaddition-ring opening transformation, generating functionalized pyrrolo[2,1-a]isoquinolines and S–S-bridged bis-pyrrolo[2,1-a]isoquinolines.

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Mechanistic understanding of the Cu(i)-catalyzed domino reaction constructing 1-aryl-1,2,3-triazole from electron-rich aryl bromide, alkyne, and sodium azide: a DFT study

Catalysis Science & Technology ◽

10.1039/d1cy00123j ◽

2021 ◽

Author(s):

Hanlin Gan ◽

Liang Peng ◽

Feng Long Gu

Keyword(s):

Density Functional Theory ◽

Dft Calculations ◽

Sodium Azide ◽

Density Functional ◽

Dft Study ◽

Domino Reaction ◽

Aryl Bromide ◽

Functional Theory ◽

Mechanistic Understanding

The mechanism of the Cu(i)-catalyzed domino reaction furnishing 1-aryl-1,2,3-triazole assisted by CuI and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is explored with density functional theory (DFT) calculations.

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Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

Chemical Communications ◽

10.1039/d1cc01015h ◽

2021 ◽

Author(s):

Penghui Dong ◽

Kashif Majeed ◽

lingna Wang ◽

Zijian Guo ◽

Fengtao Zhou ◽

...

Keyword(s):

Transition Metal ◽

Aldol Condensation ◽

Domino Reaction ◽

Tandem Reaction ◽

Metal Free ◽

Successive Formation ◽

General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

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Convenient synthesis of hexasubstituted benzene derivatives via DABCO promoted domino reaction of arylidene malononitrile and dialkyl but-2-ynedioate

Chinese Chemical Letters ◽

10.1016/j.cclet.2020.12.024 ◽

2020 ◽

Author(s):

Hui Zheng ◽

Ying Han ◽

Jing Sun ◽

Chao-Guo Yan

Keyword(s):

Domino Reaction ◽

Benzene Derivatives ◽

Convenient Synthesis

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Combining Wittig Olefination with Photoassisted Domino Reaction To Distinguish 5-Formylcytosine from 5-Formyluracil

Analytical Chemistry ◽

10.1021/acs.analchem.9b02499 ◽

2019 ◽

Vol 91 (15) ◽

pp. 9366-9370 ◽

Cited By ~ 2

Author(s):

Qian Zhou ◽

Kun Li ◽

Ling-Ling Li ◽

Kang-Kang Yu ◽

Hong Zhang ◽

...

Keyword(s):

Domino Reaction ◽

Wittig Olefination

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Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

Chemical Communications ◽

10.1039/d0cc00594k ◽

2020 ◽

Vol 56 (55) ◽

pp. 7665-7668 ◽

Cited By ~ 1

Author(s):

Lu Liu ◽

Lei Li ◽

Shukuan Mao ◽

Xin Wang ◽

Ming-Dong Zhou ◽

...

Keyword(s):

Diazo Compounds ◽

Domino Reaction ◽

Reaction Conditions ◽

One Pot ◽

One Pot Synthesis ◽

Quinazoline Derivatives

Various o-alkenyl aromatic isocyanides were prepared from readily available reactants for their double annulation with diazo compounds for a one-pot synthesis of pyrazolo[1,5-c]quinazolines under mild reaction conditions.

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Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles

Organic & Biomolecular Chemistry ◽

10.1039/d0ob02122a ◽

2021 ◽

Author(s):

Mahesh P. Paudyal ◽

Mingliang Wang ◽

Juha H. Siitonen ◽

Yimin Hu ◽

Muhammed Yousufuddin ◽

...

Keyword(s):

Ring Opening ◽

Domino Reaction ◽

Aziridine Ring

A mild Rh-catalyzed method for synthesis of cyclic unprotected N–Me and N–H 2,3-aminoethers using an olefin aziridination–aziridine ring-opening domino reaction has been developed.

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