Tuning of Polymeric Nanoparticles by Coassembly of Thermoresponsive Polymers and a Double Hydrophilic Thermoresponsive Block Copolymer

2016 ◽  
Vol 120 (20) ◽  
pp. 4635-4643 ◽  
Author(s):  
Qilu Zhang ◽  
Lenny Voorhaar ◽  
Sergey K. Filippov ◽  
Berin Fatma Yeşil ◽  
Richard Hoogenboom
Keyword(s):  
Block Copolymer ◽  
Polymeric Nanoparticles ◽  
Thermoresponsive Polymers

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

Solvent Effects on the Synthesis of Polymeric Nanoparticles via Block Copolymer Self-Assembly Using Microporous Membranes

2020 ◽  
Vol 1000 ◽  
pp. 324-330
Author(s):  
Sri Agustina ◽  
Masayoshi Tokuda ◽  
Hideto Minami ◽  
Cyrille Boyer ◽  
Per B. Zetterlund
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Raft Polymerization ◽  
Membrane Emulsification ◽  
Membrane Pore ◽  
Novel Technique ◽  
Wide Range ◽  
Membrane Pore Size

The self-assembly of block copolymers has attracted attention for many decades because it can yield polymeric nanoobjects with a wide range of morphologies. Membrane emulsification is a fairly novel technique for preparation of various types of emulsions, which relies on the dispersed phase passing through a membrane in order to effect droplet formation. In this study, we have prepared polymeric nanoparticles of different morphologies using self-assembly of asymmetric block copolymers in connection with membrane emulsification. Shirasu Porous Glass (SPG) membranes has been employed as the membrane emulsification equipment, and poly (oligoethylene glycol acrylate)-block-poly (styrene) (POEGA-b-PSt) copolymers prepared via RAFT polymerization. It has been found that a number of different morphologies can be achieved using this novel technique, including spheres, rods, and vesicles. Interestingly, the results have shown that the morphology can be controlled not only by adjusting experimental parameters specific to the membrane emulsification step such as membrane pore size and pressure, but also by changing the nature of organic solvent. As such, this method provides a novel route to these interesting nanoobjects, with interesting prospects in terms of exercising morphology control without altering the nature of the block copolymer itself.

Degradable polymeric nanoparticles by aggregation of thermoresponsive polymers and “click” chemistry

Nanoscale ◽  
2015 ◽  
Vol 7 (40) ◽  
pp. 16823-16833 ◽  
Author(s):  
Andrzej Dworak ◽  
Daria Lipowska ◽  
Dawid Szweda ◽  
Jerzy Suwinski ◽  
Barbara Trzebicka ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Polymeric Nanoparticles ◽  
Thermoresponsive Polymers ◽  
Novel Approach

This study describes a novel approach to the preparation of crosslinked polymeric nanoparticles of controlled sizes that can be degraded under basic conditions.

Shaping Block Copolymer Microparticles by pH-Responsive Core-Cross-Linked Polymeric Nanoparticles

Langmuir ◽  
2020 ◽  
Author(s):  
Mengmeng Zhang ◽  
Zaiyan Hou ◽  
Huiying Wang ◽  
Lianbin Zhang ◽  
Jiangping Xu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Polymeric Nanoparticles ◽  
Ph Responsive

scholarly journals Formulation and Evaluation of Paclitaxel-Loaded Polymeric Nanoparticles Composed of Polyethylene Glycol and Polylactic Acid Block Copolymer

2012 ◽  
Vol 35 (8) ◽  
pp. 1306-1313 ◽  
Author(s):  
Tomoya Araki ◽  
Yusuke Kono ◽  
Ken-ichi Ogawara ◽  
Takaichi Watanabe ◽  
Tsutomu Ono ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Block Copolymer ◽  
Polylactic Acid ◽  
Polymeric Nanoparticles

Polymeric nanoparticles, micelles and polymersomes from amphiphilic block copolymer

2010 ◽  
Vol 27 (3) ◽  
pp. 731-740 ◽  
Author(s):  
Heui Kyoung Cho ◽  
In Woo Cheong ◽  
Jung Min Lee ◽  
Jung Hyun Kim
Keyword(s):  
Block Copolymer ◽  
Polymeric Nanoparticles ◽  
Amphiphilic Block Copolymer

Polymeric nanoparticles with tunable architecture formed by biocompatible star shaped block copolymer

Polymer ◽  
2012 ◽  
Vol 53 (21) ◽  
pp. 4569-4578 ◽  
Author(s):  
P. Alonso-Cristobal ◽  
M. Laurenti ◽  
F.J. Sanchez-Muniz ◽  
E. López-Cabarcos ◽  
J. Rubio-Retama
Keyword(s):  
Block Copolymer ◽  
Polymeric Nanoparticles

scholarly journals Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

Membranes ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 105
Author(s):  
Lakshmeesha Upadhyaya ◽  
Mona Semsarilar ◽  
Damien Quemener ◽  
Rodrigo Fernández-Pacheco ◽  
Gema Martinez ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Block Copolymer ◽  
Membrane Fouling ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Superparamagnetic Nanoparticles ◽  
Mixed Matrix Membranes ◽  
Nanocomposite Membranes ◽  
The Impact ◽  
The Magnetic Field

In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes.

Miniaturised preparation of polymeric nanoparticles using droplet manipulation on open surfaces

2019 ◽  
Vol 14 (13) ◽  
pp. 1312-1316 ◽  
Author(s):  
Alsaeed M. Abualsayed ◽  
Sara A. Abouelmagd ◽  
Mohamed Abdelgawad
Keyword(s):  
Polymeric Nanoparticles ◽  
Droplet Manipulation
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