Functional Group Adsorption on Calcite: I. Oxygen Containing and Nonpolar Organic Molecules

2016 ◽  
Vol 120 (30) ◽  
pp. 16586-16596 ◽  
Author(s):  
E. Ataman ◽  
M. P. Andersson ◽  
M. Ceccato ◽  
N. Bovet ◽  
S. L. S. Stipp
Keyword(s):  
Organic Molecules ◽  
Functional Group ◽  
Nonpolar Organic

Relation between van der Waals and Partial Molal Volumes of Organic Molecules in Water

1975 ◽  
Vol 53 (19) ◽  
pp. 2965-2970 ◽  
Author(s):  
John T. Edward ◽  
Patrick G. Farrell
Keyword(s):  
Organic Molecules ◽  
Van Der Waals ◽  
Polar Compounds ◽  
Total Surface Area ◽  
Polar Group ◽  
Partial Molal Volumes ◽  
Aliphatic Carbon ◽  
Urea Group ◽  
Molal Volumes ◽  
Nonpolar Organic

The partial molal volumes [Formula: see text] of nonpolar organic molecules (i.e. those having more than three aliphatic carbon atoms per polar hydroxyl, ether, amine, amide, or urea group) in water at 25 °C are given by their van der Waals volumes υw plus the additional empty volume provided by an enclosing shell 0.53 Å thick. An equation relates [Formula: see text] to υw More polar compounds (i.e. those having fewer than two or three aliphatic carbon atoms per polar group) have [Formula: see text] smaller than calculated by the equation; the shrinkage in [Formula: see text] from that computed is linearly related to the fraction of the total surface area of the molecule occupied by the polar group.

scholarly journals Polarization Reversal in AlPO4-5 Crystals Containing Polar or Nonpolar Organic Molecules:  A Scanning Pyroelectric Microscopy Study

1998 ◽  
Vol 102 (47) ◽  
pp. 9518-9524 ◽  
Author(s):  
G. J. Klap ◽  
S. M. van Klooster ◽  
M. Wübbenhorst ◽  
J. C. Jansen ◽  
H. van Bekkum ◽  
...  
Keyword(s):  
Organic Molecules ◽  
Microscopy Study ◽  
Polarization Reversal ◽  
Nonpolar Organic

Enantioselective C(sp3)–C(sp3) Cross-Coupling of Non-activated Alkyl Electrophiles via Nickel Hydride Catalysis

2020 ◽  
Author(s):  
Srikrishna Bera ◽  
Runze Mao ◽  
Xile Hu
Keyword(s):  
Organic Molecules ◽  
Functional Group ◽  
Cross Coupling ◽  
Building Blocks ◽  
Carbon Centers ◽  
Mild Conditions ◽  
Drug Molecules ◽  
Nickel Hydride ◽  
Alkyl Electrophiles ◽  
Attractive Candidate

Cross-coupling of two alkyl fragments is an efficient method to produce organic molecules rich in sp<sup>3</sup>-hydridized carbon centers, which are attractive candidate compounds in drug discovery. Enantioselective C(sp<sup>3</sup>)-C(sp<sup>3</sup>) coupling, especially of alkyl electrophiles without an activating group (aryl, vinyl, carbonyl) is challenging. Here we report a strategy based on nickel hydride addition to internal olefins followed by nickel-catalyzed alkyl-alkyl coupling. This strategy enables enantioselective cross-coupling of non-activated alkyl iodides with alkenyl boronates to produce chiral alkyl boronates. Employing readily available and stable olefins as pro-chiral nucleophiles, the coupling proceeds under mild conditions and exhibits broad scope and high functional group tolerance. Applications in late-stage functionalization of natural products and drug molecules, synthesis of chiral building blocks, and enantioselective formal synthesis of (<i>S</i>)-(+)-Pregabalin are demonstrated.<br>

Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds

2019 ◽  
Author(s):  
Jeremy Nugent ◽  
Carlos Arroniz ◽  
Bethany Shire ◽  
Alistair J. Sterling ◽  
Helena D. Pickford ◽  
...  
Keyword(s):  
Visible Light ◽  
Organic Molecules ◽  
Functional Group ◽  
Single Step ◽  
Transition Metal Catalysts ◽  
Organic Radicals ◽  
Photoredox Catalysis ◽  
Halogen Bonds ◽  
Organic Halides ◽  
Pi Bonds

<p>The use of visible light to activate transition metal catalysts towards redox processes has transformed the way organic molecules can be constructed. Promotion of an electron to an excited state enables the generation of organic radicals through electron transfer to or from the metal complex, with the resulting radicals primed for reactions such as addition to carbon–carbon pi bonds. Despite advances in photoredox catalysis which have led to the discovery of numerous such methods for bond construction, this mild approach to the generation of free radicals has not been applied to the functionalisation of carbon–carbon sigma<i></i>bonds. Here we report the first such use of photoredox catalysis to promote the addition of organic halides to the caged carbocycle [1.1.1]propellane; the products of this process are bicyclo[1.1.1]pentanes (BCPs), motifs that are of high importance as bioisosteres in the pharmaceutical industry, and in materials applications. The methodology shows broad substrate scope and functional group tolerance, and is applicable to both <i>sp</i><sup>2</sup>and <i>sp</i><sup>3</sup>carbon–halogen bonds, while the use of substrates containing alkene acceptors enables the single-step construction of polycyclic bicyclopentane products through cyclisation cascades. Finally, the potential to accelerate drug discovery is demonstrated through examples of late-stage bicyclopentylation to access natural product- and drug-like molecules.</p>

scholarly journals Erratum: Ferroelectricity near room temperature in co-crystals of nonpolar organic molecules

2008 ◽  
Vol 7 (11) ◽  
pp. 922-922 ◽  
Author(s):  
Sachio Horiuchi ◽  
Fumiyuki Ishii ◽  
Reiji Kumai ◽  
Yoichi Okimoto ◽  
Hiroaki Tachibana ◽  
...  
Keyword(s):  
Room Temperature ◽  
Organic Molecules ◽  
Nonpolar Organic

Functional group dependent dissociative electron attachment to simple organic molecules

2008 ◽  
Vol 128 (15) ◽  
pp. 154309 ◽  
Author(s):  
Vaibhav S. Prabhudesai ◽  
Dhananjay Nandi ◽  
Aditya H. Kelkar ◽  
E. Krishnakumar
Keyword(s):  
Organic Molecules ◽  
Functional Group ◽  
Electron Attachment ◽  
Dissociative Electron Attachment

Advances in C(sp3)–H Bond Functionalization via Radical Processes

Synthesis ◽  
2019 ◽  
Vol 51 (24) ◽  
pp. 4531-4548 ◽  
Author(s):  
Tong Zhang ◽  
Yue-Hua Wu ◽  
Nai-Xing Wang ◽  
Yalan Xing
Keyword(s):  
Free Radicals ◽  
Hydrogen Atom ◽  
Functional Groups ◽  
Organic Molecules ◽  
Functional Group ◽  
Hydrogen Atom Transfer ◽  
Significant Progress ◽  
Bond Functionalization ◽  
Direct Functionalization ◽  
Radical Processes

C(sp3)–H Bonds are the most common structures in organic molecules. In recent years, the direct functionalization of C(sp3)–H bonds has attracted wide attention and made significant progress. This review mainly focuses on C(sp3)–H bond functionalization of alkanes with or without functional groups via radical processes reported since 2017. In particular, three methods of generating free radicals are discussed: the use of a radical initiator such as TBHP or DTBP; photocatalysis, and via 1,5-hydrogen atom transfer (1,5-HAT).1 Introduction2 C(sp3)–H Bond Functionalization of Alkanes3 C(sp3)–H Bond Functionalization of Alkanes with a Functional Group4 Conclusions

Ferroelectricity near room temperature in co-crystals of nonpolar organic molecules

2005 ◽  
Vol 4 (2) ◽  
pp. 163-166 ◽  
Author(s):  
Sachio Horiuchi ◽  
Fumiyuki Ishii ◽  
Reiji Kumai ◽  
Yoichi Okimoto ◽  
Hiroaki Tachibana ◽  
...  
Keyword(s):  
Room Temperature ◽  
Organic Molecules ◽  
Nonpolar Organic
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