scholarly journals Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity

2021 ◽  
Author(s):  
Kaylie I. Kirkwood ◽  
Michael W. Christopher ◽  
Jefferey L. Burgess ◽  
Sally R. Littau ◽  
Kevin Foster ◽  
...  
Keyword(s):  
Injury Severity ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Smoke Inhalation Injury

scholarly journals Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity

2021 ◽  
Author(s):  
Kaylie I Kirkwood ◽  
Michael W Christopher ◽  
Jefferey L Burgess ◽  
Sally R Littau ◽  
Brian S Pratt ◽  
...  
Keyword(s):  
Human Plasma ◽  
Retention Time ◽  
Injury Severity ◽  
Structural Information ◽  
Drift Time ◽  
Lavage Fluid ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Toxic Exposure ◽  
Smoke Inhalation Injury

Lipids play many biological roles including membrane formation, protection, insulation, energy storage, and cell division. These functions have brought great interest to lipidomic studies for understanding their dysregulation in toxic exposure, inflammation, and diseases. However, lipids have shown to be analytically challenging due to their highly isomeric nature and vast concentration ranges in biological matrices. Therefore, powerful multidimensional techniques such as those integrating liquid chromatography, ion mobility spectrometry, collision induced dissociation, and mass spectrometry (LC-IMS-CID-MS) have recently been implemented to separate lipid isomers as well as provide structural information and increased feature identification confidence. These multidimensional datasets are however extremely large and highly complex, resulting in challenges in data processing and annotation. Here, we have overcome these challenges by developing sample-specific multidimensional libraries using the freely available software Skyline. Specifically, the human plasma library developed for this work contains over 500 unique, experimentally validated lipids, which is combined with adapted Skyline functions for highly confident lipid annotations such as indexed retention time (iRT) for retention time prediction and IMS drift time filtering for increased sensitivity and selectivity. For broad comparison with other lipidomic studies, this human plasma database was initially used to annotate LC-IMS-CID-MS data from a NIST SRM 1950 extract, giving comparable results to previous studies. This workflow was then utilized to assess matched plasma and bronchoalveolar lavage fluid (BALF) samples from patients with varying degrees of smoke inhalation injury to identify potential lipid-based patient prognostic and diagnostic markers.

scholarly journals An Analysis of Airway Interventions in the Setting of Smoke Inhalation Injury on the Battlefield

2020 ◽  
Author(s):  
Steven G Schauer ◽  
Jason F Naylor ◽  
Gregory Dion ◽  
Michael D April ◽  
Kevin K Chung ◽  
...  
Keyword(s):  
Injury Severity ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Published Data ◽  
Smoke Inhalation Injury ◽  
Airway Intervention ◽  
Oropharyngeal Airway ◽  
Combat Casualty ◽  
Inhalational Injury ◽  
Combat Casualties

Abstract Introduction The Committee on Tactical Combat Casualty Care and Capabilities Development and Integration Directorate cite airway burn injuries as an indication for prehospital cricothyrotomy. We sought to build on previously published data by describing for the first time the incidence of prehospital airway interventions in combat casualties who received airway management in the setting of inhalational injuries.15,26 We hypothesized that (1) airway interventions in combat casualties who suffered inhalational injury would have a higher mortality rate than those without airway intervention and (2) prehospital cricothyrotomy was used with greater incidence than endotracheal intubation. Materials and Methods Using a previously described Department of Defense Trauma Registry dataset from January 2007 to August 2016, unique casualties with documented inhalational injury were identified. Results Our predefined search codes captured 28,222 (72.8% of all encounters in the registry) of those subjects. A total of 347 (1.2%) casualties had a documented inhalational injury, 27 (7.8%) of those with at least 1 prehospital airway intervention inhalational injuries (0.09% of our dataset [n = 28,222]). Within the subset of patients with an inhalation injury, 23 underwent intubation, 2 underwent cricothyrotomy, 3 had placement of an airway adjunct not otherwise specifically listed, and 1 casualty had both a cricothyrotomy and intubation documented. No casualties had a supraglottic, nasopharyngeal, or oropharyngeal airway listed. Contrary to our hypotheses, of those with an airway intervention, 74.0% survived to hospital discharge. In multivariable regression models, when adjusting for confounders, there was no difference in survival to discharge in those with an airway intervention compared to those without. Conclusions Casualties undergoing airway intervention for inhalation injuries had similar survival adjusting for injury severity, supporting its role when indicated. Without case-specific data on airway status and interventions, it is challenging to determine if the low rate of cricothyrotomy in this population was a result of rapid transport to a more advanced provider capable of performing intubation or cricothyrotomy may not be meeting the needs of the medics.

Computed tomographic assessment of airflow obstruction in smoke inhalation injury: Relationship with the development of pneumonia and injury severity

Burns ◽  
2015 ◽  
Vol 41 (7) ◽  
pp. 1428-1434 ◽  
Author(s):  
Hitoshi Yamamura ◽  
Takasei Morioka ◽  
Naohiro Hagawa ◽  
Tomonori Yamamoto ◽  
Yasumitsu Mizobata
Keyword(s):  
Injury Severity ◽  
Airflow Obstruction ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Smoke Inhalation Injury ◽  
Computed Tomographic

scholarly journals Association of uteroglobin-related protein 1 with smoke inhalation injury severity

2021 ◽  
Vol 33 (2) ◽  
Author(s):  
Sabrina Frighetto Henrich ◽  
Tatiana Helena Rech ◽  
Cristiane Ritter ◽  
Monique Michels ◽  
Felipe Dal-Pizzol ◽  
...  
Keyword(s):  
Injury Severity ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Related Protein ◽  
Smoke Inhalation Injury

scholarly journals Bilateral Lobar Lung Transplantation after Smoke Inhalation Injury - A Case Report

2021 ◽  
Vol 40 (4) ◽  
pp. S515
Author(s):  
E. Olsson ◽  
M. Silverborn ◽  
U. Smedh ◽  
G.C. Riise ◽  
J.M. Magnusson ◽  
...  
Keyword(s):  
Case Report ◽  
Lung Transplantation ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Smoke Inhalation Injury

523 Retrospective Outcomes Analysis of Tracheostomy in Paediatric Burn Population

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S108-S109
Author(s):  
Nicholas Iglesias ◽  
Anesh Prasai ◽  
George Golovko ◽  
Deepak K Ozhathil ◽  
Steven E Wolf
Keyword(s):  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Research Network ◽  
Burn Patients ◽  
Pulmonary Injury ◽  
Smoke Inhalation Injury ◽  
Mortality And Morbidity ◽  
Laryngeal Injury ◽  
Icd 10 ◽  
Potential Benefits

Abstract Introduction For decades, controversy has raged regarding the placement of tracheostomy in severe paediatric burns. Numerous variables including extent of smoke inhalation injury, % TBSA burned, age of the patient, and co-morbidities among others complicate reaching consensus. Furthermore, paediatric patients are particularly susceptible to complications including inadvertent loss of airway and long-term swallowing and other anatomic issues. Additionally, previous analysis of the efficacy of tracheostomy in paediatric burn patients appears to be hindered by a lack of nationwide analysis. The aim of this study was to explore the efficacy of tracheostomy in the general paediatric burn patient population. Methods De-identified patient data was obtained from the TriNetX Research Network database. Two cohorts were identified: paediatric burn patients with tracheostomy (cohort A) and paediatric burn patients without tracheostomy (cohort B). Burn patients were identified using the ICD-10 codes T20-T25 & T30-T32. Tracheostomy was identified using the ICD-10 codes 1005887, 1014613, 31600, 31601, 31603, 31604, 31610, and Z93.0. A total of 132 patients were identified in cohort A in 23 HCOs and 83,117 patients were identified in cohort B in 38 HCOs. Infection, hypovolemia, pulmonary injury, laryngeal injury, pneumonia, and death were compared between the cohorts. Results Cohort A had a mean age of 11 (SD=5) and Cohort B had a mean age of 9 (SD=5). Paediatric burn patients with tracheostomy had a higher risk for death, infection, hypovolemia, pulmonary injury, laryngeal injury, and pneumonia when compared to their non-tracheostomy counterparts. The risk ratios for these outcomes were 62.452, 4.713, 9.267, 26.483, 116.163, and 18.154, respectively. Conclusions The analysis of the longitudinal outcomes of pediatric burn patients with tracheostomy as compared to those without tracheostomy demonstrated the tracheostomy cohort suffered much worse mortality and morbidity across several metrics. The potential benefits of tracheostomy placement in pediatric burn patients should be weighed against these outcomes.

Role of anti-L-selectin antibody in burn and smoke inhalation injury in sheep

2002 ◽  
Vol 283 (5) ◽  
pp. L1043-L1050 ◽  
Author(s):  
Jiro Katahira ◽  
Kazunori Murakami ◽  
Frank C. Schmalstieg ◽  
Robert Cox ◽  
Hal Hawkins ◽  
...  
Keyword(s):  
Leukocyte Adhesion ◽  
Experimental Period ◽  
Inhalation Injury ◽  
Lymph Flow ◽  
Smoke Inhalation ◽  
Control Group ◽  
Fluid Flux ◽  
Smoke Inhalation Injury ◽  
Lung Lymph ◽  
Lung Lymph Flow

We hypothesized that the antibody neutralization of L-selectin would decrease the pulmonary abnormalities characteristic of burn and smoke inhalation injury. Three groups of sheep ( n = 18) were prepared and randomized: the LAM-(1–3) group ( n = 6) was injected intravenously with 1 mg/kg of leukocyte adhesion molecule (LAM)-(1-3) (mouse monoclonal antibody against L-selectin) 1 h after the injury, the control group ( n = 6) was not injured or treated, and the nontreatment group ( n = 6) was injured but not treated. All animals were mechanically ventilated during the 48-h experimental period. The ratio of arterial Po 2 to inspired O2 fraction decreased in the LAM-(1–3) and nontreatment groups. Lung lymph flow and pulmonary microvascular permeability were elevated after injury. This elevation was significantly reduced when LAM-(1–3) was administered 1 h after injury. Nitrate/nitrite (NO x ) amounts in plasma and lung lymph increased significantly after the combined injury. These changes were attenuated by posttreatment with LAM-(1–3). These results suggest that the changes in pulmonary transvascular fluid flux result from injury of lung endothelium by polymorphonuclear leukocytes. In conclusion, posttreatment with the antibody for L-selectin improved lung lymph flow and permeability index. L-selectin appears to be principally involved in the increased pulmonary transvascular fluid flux observed with burn/smoke insult. L-selectin may be a useful target in the treatment of acute lung injury after burn and smoke inhalation.

scholarly journals Blood–Brain Barrier Dysfunction After Smoke Inhalation Injury, With and Without Skin Burn

Shock ◽  
2019 ◽  
Vol 51 (5) ◽  
pp. 634-649 ◽  
Author(s):  
Anita C. Randolph ◽  
Satoshi Fukuda ◽  
Koji Ihara ◽  
Perenlei Enkhbaatar ◽  
Maria-Adelaide Micci
Keyword(s):  
Blood Brain Barrier ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Skin Burn ◽  
Smoke Inhalation Injury ◽  
Blood Brain

scholarly journals Smoke inhalation injury

BJA Education ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Preea Gill ◽  
Rebecca V Martin
Keyword(s):  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Smoke Inhalation Injury
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