scholarly journals Optimizing High-Resolution Mass Spectrometry for the Identification of Low-Abundance Post-Translational Modifications of Intact Proteins

2017 ◽  
Vol 16 (9) ◽  
pp. 3255-3265 ◽  
Author(s):  
Lisa E. Kilpatrick ◽  
Eric L. Kilpatrick
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Post Translational Modifications ◽  
Intact Proteins ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals N-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis using ion mobility-MS/MS

The Analyst ◽  
2020 ◽  
Vol 145 (5) ◽  
pp. 1737-1748
Author(s):  
Alessandro Quaranta ◽  
Maya Spasova ◽  
Elena Passarini ◽  
Isabella Karlsson ◽  
Lorena Ndreu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quality Control ◽  
High Resolution ◽  
Ion Mobility ◽  
High Resolution Mass Spectrometry ◽  
Target Proteins ◽  
Intact Proteins ◽  
Glycan Analysis ◽  
High Resolution Mass ◽  
Resolution Mass

Glycosylation characterization could lead to the discovery of biomarkers and is crucial in quality control of biopharmaceuticals. Here we present a method to quantify glycoforms on intact proteins, with parallel glycan identification by IMS-MS/MS.

Rapid phenotype hemoglobin screening by high-resolution mass spectrometry on intact proteins

2016 ◽  
Vol 460 ◽  
pp. 220-226 ◽  
Author(s):  
Floris Helmich ◽  
Joost L.J. van Dongen ◽  
Philip H.M. Kuijper ◽  
Volkher Scharnhorst ◽  
Luc Brunsveld ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Intact Proteins ◽  
High Resolution Mass ◽  
Resolution Mass

Salivary Cystatins: Exploring New Post-Translational Modifications and Polymorphisms by Top-Down High-Resolution Mass Spectrometry

2017 ◽  
Vol 16 (11) ◽  
pp. 4196-4207 ◽  
Author(s):  
Barbara Manconi ◽  
Barbara Liori ◽  
Tiziana Cabras ◽  
Federica Vincenzoni ◽  
Federica Iavarone ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Top Down ◽  
Post Translational Modifications ◽  
High Resolution Mass ◽  
Resolution Mass
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