Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

2018 ◽  
Vol 16 (1) ◽  
pp. 292-304 ◽  
Author(s):  
Hiroki Kuroda ◽  
Masanori Tachikawa ◽  
Yuta Yagi ◽  
Mina Umetsu ◽  
Armania Nurdin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Metastatic Melanoma ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Melanoma Cells ◽  
Brain Barrier ◽  
Blood Brain ◽  
Cluster Of Differentiation

scholarly journals 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

Biomaterials ◽  
2018 ◽  
Vol 180 ◽  
pp. 117-129 ◽  
Author(s):  
Marco Campisi ◽  
Yoojin Shin ◽  
Tatsuya Osaki ◽  
Cynthia Hajal ◽  
Valeria Chiono ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Brain Barrier ◽  
Self Organized ◽  
Blood Brain

scholarly journals Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0139101 ◽  
Author(s):  
Barbara Bennani-Baiti ◽  
Stefan Toegel ◽  
Helmut Viernstein ◽  
Ernst Urban ◽  
Christian R. Noe ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Housekeeping Genes ◽  
Brain Barrier ◽  
Glutathione Conjugate ◽  
Blood Brain

scholarly journals Human Blood Vessel Organoids Penetrate Human Cerebral Organoids and Form a Vessel-Like System

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2036
Author(s):  
Yujin Ahn ◽  
Ju-Hyun An ◽  
Hae-Jun Yang ◽  
Dong Gil Lee ◽  
Jieun Kim ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Cell Types ◽  
Brain Barrier ◽  
Vascular Cells ◽  
Blood Brain ◽  
Vessel Networks

Vascularization of tissues, organoids and organ-on-chip models has been attempted using endothelial cells. However, the cultured endothelial cells lack the capacity to interact with other somatic cell types, which is distinct from developing vascular cells in vivo. Recently, it was demonstrated that blood vessel organoids (BVOs) recreate the structure and functions of developing human blood vessels. However, the tissue-specific adaptability of BVOs had not been assessed in somatic tissues. Herein, we investigated whether BVOs infiltrate human cerebral organoids and form a blood–brain barrier. As a result, vascular cells arising from BVOs penetrated the cerebral organoids and developed a vessel-like architecture composed of CD31+ endothelial tubes coated with SMA+ or PDGFR+ mural cells. Molecular markers of the blood-brain barrier were detected in the vascularized cerebral organoids. We revealed that BVOs can form neural-specific blood-vessel networks that can be maintained for over 50 days.

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