Kinetics, Thermodynamics, and Scale-Up of an Azeotropic Drying Process: Mapping Rapid Phase Conversion with Process Analytical Technology

2020 ◽  
Vol 24 (9) ◽  
pp. 1665-1674
Author(s):  
Zachary E. X. Dance ◽  
Morgan Crawford ◽  
Aaron Moment ◽  
Andrew Brunskill ◽  
Busolo Wabuyele
Keyword(s):  
Process Analytical Technology ◽  
Scale Up ◽  
Process Mapping ◽  
Drying Process ◽  
Phase Conversion ◽  
Rapid Phase ◽  
Analytical Technology

At-line process analytical technology (PAT) for more efficient scale up of biopharmaceutical microfiltration unit operations

2015 ◽  
Vol 32 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Douglas S. Watson ◽  
Kristi R. Kerchner ◽  
Sean S. Gant ◽  
Joseph W. Pedersen ◽  
James B. Hamburger ◽  
...  
Keyword(s):  
Process Analytical Technology ◽  
Scale Up ◽  
Unit Operations ◽  
Line Process ◽  
Analytical Technology

Development and in-line validation of a Process Analytical Technology to facilitate the scale up of coating processes

2013 ◽  
Vol 78-79 ◽  
pp. 57-64 ◽  
Author(s):  
M. Wirges ◽  
A. Funke ◽  
P. Serno ◽  
K. Knop ◽  
P. Kleinebudde
Keyword(s):  
Process Analytical Technology ◽  
Scale Up ◽  
Analytical Technology

Scale-Up of Freeze-Drying Cycles, the Use of Process Analytical Technology (PAT), and Statistical Analysis

2018 ◽  
pp. 215-240 ◽  
Author(s):  
Erwan Bourlès ◽  
Gael de Lannoy ◽  
Bernadette Scutellà ◽  
Fernanda Fonseca ◽  
Ioan Cristian Trelea ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Freeze Drying ◽  
Process Analytical Technology ◽  
Scale Up ◽  
Analytical Technology

In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools

2009 ◽  
Vol 98 (9) ◽  
pp. 3430-3446 ◽  
Author(s):  
T.R.M. De Beer ◽  
P. Vercruysse ◽  
A. Burggraeve ◽  
T. Quinten ◽  
J. Ouyang ◽  
...  
Keyword(s):  
Real Time ◽  
Process Monitoring ◽  
Freeze Drying ◽  
Process Analytical Technology ◽  
Nir Spectroscopy ◽  
Time Process ◽  
Drying Process ◽  
Analytical Technology

Implementation of a Process Analytical Technology System in a Freeze-Drying Process Using Raman Spectroscopy for In-Line Process Monitoring

2007 ◽  
Vol 79 (21) ◽  
pp. 7992-8003 ◽  
Author(s):  
T. R. M. De Beer ◽  
M. Allesø ◽  
F. Goethals ◽  
A. Coppens ◽  
Y. Vander Heyden ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Process Monitoring ◽  
Freeze Drying ◽  
Process Analytical Technology ◽  
Drying Process ◽  
Technology System ◽  
Line Process ◽  
Analytical Technology

scholarly journals Experimental and Numerical Investigations on Conductive Drying of Phosphate Washing Waste Clay

Minerals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 482
Author(s):  
Fatiha Berroug ◽  
Yassir Bellaziz ◽  
Naaila Ouazzani ◽  
Fatima Ait Nouh ◽  
Abdessamad Hejjaj ◽  
...  
Keyword(s):  
Scale Up ◽  
Free Water ◽  
Moisture Diffusivity ◽  
Sample Thickness ◽  
Total Production ◽  
Drying Process ◽  
One Dimensional ◽  
Numerical Investigations ◽  
The World ◽  
Drying System

Morocco is the leading producer of phosphate and its derivatives in the world with a total production of 35 Mt. However, the extraction and the valorization of this mine generate huge quantities of phosphate washing waste clay (PHWWC) that constitute a main environmental and economic concern. To facilitate this waste clay storage and handling, it is necessary to decrease its moisture content that represents 80% of PHWWC. The present paper is devoted to studying the conductive drying of PHWWC. Drying experiments were conducted in a laboratory pilot. Afterwards, the experiment results were implemented in a one-dimensional numerical model of heat and mass transfer in a porous media to identify the drying parameters and performances. It was found that most of the water contained in PHWWC is free water that is removed with a constant drying rate. The volume reduction with a marked cracks phenomenon attained 65% without any significant effect of drying temperature and sample thickness. The effective moisture diffusivity of the PHWWC for a conductive drying process is ranged between 10−9 and 1.1 × 10−8 m2·s−1. The thermal efficiency of the drying system is up to 86%. The results could be used for the purpose of design and scale-up of the industrial dryer based on laboratory-scale experiments.

scholarly journals Exploiting Fluorescent Reporter Molecules for Process Analytical Technology (PAT)

2009 ◽  
Vol 63 (3) ◽  
pp. 171-173 ◽  
Author(s):  
Tobias Broger ◽  
Res P. Odermatt ◽  
Pablo Ledergerber ◽  
Bernhard Sonnleitner
Keyword(s):  
Process Analytical Technology ◽  
Fluorescent Reporter ◽  
Analytical Technology
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