scholarly journals Injectable Highly Tunable Oligomeric Collagen Matrices for Dental Tissue Regeneration

2020 ◽  
Vol 3 (2) ◽  
pp. 859-868 ◽  
Author(s):  
Divya Pankajakshan ◽  
Sherry L. Voytik-Harbin ◽  
Jacques E. Nör ◽  
Marco C. Bottino
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue ◽  
Collagen Matrices

scholarly journals Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 136
Author(s):  
Masahiko Terauchi ◽  
Atsushi Tamura ◽  
Yoshinori Arisaka ◽  
Hiroki Masuda ◽  
Tetsuya Yoda ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Formation ◽  
Small Molecule ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Inclusion Complexation ◽  
Dental Tissue ◽  
Polyelectrolyte Complexes ◽  
Small Molecule Drugs

Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. Additionally, small-molecule drugs that promote bone formation have been identified and tested as new regenerative treatment. However, treatments need to progress to realize successful regeneration of oral functions. In this review, we describe recent progress in development of regenerative treatment of oral tissues. In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. CDs can encapsulate hydrophobic small-molecule drugs into their cavities, resulting in inclusion complexes. The inclusion complexation of osteoinductive small-molecule drugs improves solubility of the drugs in aqueous solutions and increases in vitro osteogenic differentiation efficiency. Additionally, various anionic polymers such as heparin and its mimetic polymers have been developed to improve stability and bioactivity of growth factors. These polymers protect growth factors from deactivation and degradation by complex formation through electrostatic interaction, leading to potentiation of bone formation ability. These approaches using an inclusion complex and polyelectrolyte complexes have great potential in the regeneration of oral tissues.

scholarly journals iPSC for Dental Tissue Regeneration

2014 ◽  
Vol 1 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Kim Hynes ◽  
Stan Gronthos ◽  
P. Mark Bartold
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue

scholarly journals Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Georgios S. Theodorou ◽  
Eleana Kontonasaki ◽  
Anna Theocharidou ◽  
Athina Bakopoulou ◽  
Maria Bousnaki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Copper Ions ◽  
Sol Gel ◽  
Antimicrobial Properties ◽  
Biological Response ◽  
Oral Bacteria ◽  
Dental Tissue ◽  
Bioactive Scaffolds

Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg2+and Cu2+or Zn2+, ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity. Finally their ability to support the attachment and long-term proliferation of Dental Pulp Stem Cells (DPSCs) was also evaluated. The results showed that conversely to their bioactive response in SBF solution, Zn-doped scaffolds proved to respond adequately regarding their mechanical strength and to be efficient regarding their biological response, in comparison to Cu-doped scaffolds, which makes them promising candidates for targeted dental stem cell odontogenic differentiation and calcified dental tissue engineering.

scholarly journals Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

2020 ◽  
Vol 8 ◽  
Author(s):  
Guoke Tang ◽  
Zhihong Tan ◽  
Wusi Zeng ◽  
Xing Wang ◽  
Changgui Shi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue ◽  
Injectable Hydrogels ◽  
Recent Advances

scholarly journals Current Insight of Collagen Biomatrix for Gingival Recession: An Evidence-Based Systematic Review

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2081
Author(s):  
Ruth Naomi ◽  
Retno Ardhani ◽  
Osa Amila Hafiyyah ◽  
Mh Busra Fauzi
Keyword(s):  
Systematic Review ◽  
Tissue Regeneration ◽  
Literature Search ◽  
Gingival Recession ◽  
Current Treatment ◽  
Gingival Tissue ◽  
Dental Tissue ◽  
Comprehensive Literature Search

Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.

scholarly journals Harvesting Mesenchymal Stem Cells for Dental Tissue Regeneration

2016 ◽  
Vol 6 (2) ◽  
pp. 73 ◽  
Author(s):  
Dinta Kathiriya ◽  
R Murali ◽  
Madhusudan Krishna ◽  
Krupali Kakkad ◽  
ParthkumarA Thakkar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Regeneration ◽  
Dental Tissue

scholarly journals In Vivo Evaluation of Decellularized Human Tooth Scaffold for Dental Tissue Regeneration

2021 ◽  
Vol 11 (18) ◽  
pp. 8472
Author(s):  
Ik-Hwan Kim ◽  
Mijeong Jeon ◽  
Kyounga Cheon ◽  
Sun Ha Kim ◽  
Han-Sung Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Tooth Development ◽  
Healing Process ◽  
Permanent Teeth ◽  
Human Tooth ◽  
Pulp Tissue ◽  
Dental Tissue ◽  
In Vivo Evaluation

Conventional root canal treatment may result in loss of tooth vitality, which can lead to unfavorable treatment outcomes. Notably, a ceased tooth development of immature permanent teeth with open apices, regeneration of periodontal ligaments (PDL), and pulp is highly expected healing process. For regeneration, the scaffold is one of the critical components that carry biological benefits. Therefore, this study evaluated a decellularized human tooth as a scaffold for the PDL and pulp tissue regeneration. A tooth scaffold was fabricated using an effective decellularization method as reported in previous studies. PDL stem cells (PDLSCs) and dental pulp stem cells (DPSCs) obtained from human permanent teeth were inoculated onto decellularized scaffolds, then cultured to transplant into immunosuppressed mouse. After 9 weeks, PDLSCs and DPSCs that were inoculated onto decellularized tooth scaffolds and cultured in an in vivo demonstrated successful differentiation. In PDLSCs, a regeneration of the cementum/PDL complex could be expected. In DPSCs, the expression of genes related to revascularization and the hard tissue regeneration showed the possibility of pulp regeneration. This study suggested that the potential possible application of decellularized human tooth could be a scaffold in regeneration PDL and pulp tissue along with PDLSCs and DPSCs, respectively, as a novel treatment method.

Odontoblast Cell Death Drives Stem Cell-Independent Cell-Rich Zone-Derived Dental Tissue Regeneration

2020 ◽  
Author(s):  
Lijuan Zhao ◽  
Atsushi Arai ◽  
Nobuyuki Udagawa ◽  
Kanji Horibe ◽  
Miroku Hara ◽  
...  
Keyword(s):  
Cell Death ◽  
Stem Cell ◽  
Tissue Regeneration ◽  
Dental Tissue
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