Hybrid Bionanocomposite Containing Magnesium Hydroxide Nanoparticles Embedded in a Carboxymethyl Cellulose Hydrogel Plus Silk Fibroin as a Scaffold for Wound Dressing Applications

Author(s):  
Reza Eivazzadeh-Keihan ◽  
Farzane Khalili ◽  
Nastaran Khosropour ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Fateme Radinekiyan ◽  
...  

Author(s):  
Reza Eivazzadeh-Keihan ◽  
Farnoush Ahmadpour ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Fateme Radinekiyan ◽  
Ali Maleki ◽  
...  


2020 ◽  
Vol 1009 ◽  
pp. 3-8
Author(s):  
Narumol Kreua-Ongarjnukool ◽  
Saowapa Thumsing Niyomthai ◽  
Kodchaporn Sarodom ◽  
Thitithip Lothong ◽  
Nopparuj Soomherun

Antibacterial wound dressing has an important key in an infection in traumatic and surgical wounds. However, the antibacterial wound dressing is high cost and few domestic medical productions. The aim of this study is to prepare a wound dressing hydrogel from hybrid gelatin/carboxymethyl cellulose (Gel/CMC) hydrogel crosslinked with citric acid at different Gel: CMC ratios of 1:1, 1:2, 1:3, and 1:4 by solvent casting. The gel fractions and swelling of 6.0%w/v CuSO4 loading hybrid Gel/CMC hydrogel (Cu-Gel/CMC hydrogel) were a maximum of about 44% to 53% and 85% to 245%, respectively. The results showed that the 1:1 Gel: CMC of hydrogel produce was the most suitable condition due to its good gel fractions and swelling behavior. The cumulative Cu2+ release was a maximum of about 45% in 7 days. The hybrid Cu-Gel/CMC hydrogel showed the zone of inhibition of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) about 16 mm and 19 mm, sequentially. The research provided that the hybrid Cu-Gel/CMC hydrogel has the potential to use in medical applications.



Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4172
Author(s):  
Laura Costa Pinho ◽  
Thais Francini Garbieri ◽  
Liliana Grenho ◽  
Marta M. Alves ◽  
Pedro Sousa Gomes ◽  
...  

Considering the role of magnesium in bone metabolism and the increasing relevance of plant-mediated green-synthesis, this work compares the bone cytocompatibility of magnesium hydroxide nanoparticles (NPs) produced by using pure water, Mg(OH)2, or a rosehip (RH) aqueous extract, Mg(OH)2RH. The NPs were evaluated for dose- and time-dependent effects on human osteoblastic and osteoclastic response, due to the direct involvement of the two cell types in bone metabolism. Mg(OH)2 NPs presented nanoplatelet-like morphology (mean diameter ~90 nm) and a crystalline structure (XRD analysis); the RH-mediated synthesis yielded smaller rounded particles (mean diameter <10 nm) with decreased crystallinity. On the ATR–FTIR spectra, both NPs presented the characteristic Mg-OH peaks; Mg(OH)2RH exhibited additional vibration bands associated with the presence of phytochemicals. On osteoblastic cells, NPs did not affect cell growth and morphology but significantly increased alkaline phosphatase (ALP) activity; on osteoclastic cells, particles had little effect in protein content, tartrate-resistant acid phosphatase (TRAP) activity, percentage of multinucleated cells, and cell area. However, compared with Mg(OH)2, Mg(OH)2RH increased osteoblastic differentiation by inducing ALP activity and promoting the expression of Runx2, SP7, Col1a1, and ALP, and had a negative effect on the expression of the osteoclastic genes NFATC1, CA2, and CTSK. These observations suggest the potential usefulness of Mg(OH)2RH NPs in bone regeneration.



2021 ◽  
pp. 110744
Author(s):  
Asmaa Ahmed Arafa ◽  
Ahmed Ali Nada ◽  
Abeer Yousry Ibrahim ◽  
Magdy Kandil Zahran ◽  
Osama A. Hakeim




2009 ◽  
Vol 191 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Wenjun Jiang ◽  
Xiao Hua ◽  
Qiaofeng Han ◽  
Xujie Yang ◽  
Lude Lu ◽  
...  






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