On-Demand Local Immunomodulation via Epigenetic Control of Macrophages Using an Inflammation-Responsive Hydrogel for Accelerated Wound Healing

2022 ◽  
Author(s):  
Hyerim Kim ◽  
Yunji Joo ◽  
Yun-Min Kook ◽  
Na Ly Tran ◽  
Sang-Heon Kim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epigenetic Control ◽  
On Demand

Injectable and pH-Sensitive Hyaluronic Acid-Based Hydrogels with On-Demand Release of Antimicrobial Peptides for Infected Wound Healing

2021 ◽  
Author(s):  
Huinan Suo ◽  
Mubashir Hussain ◽  
Hua Wang ◽  
Nuoya Zhou ◽  
Juan Tao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Antimicrobial Peptides ◽  
Ph Sensitive ◽  
Infected Wound ◽  
On Demand

Synergistic and On-Demand Release of Ag-AMPs Loaded on Porous Silicon Nanocarriers for Antibacteria and Wound Healing

2021 ◽  
Author(s):  
Yao Jin ◽  
Yudong Yang ◽  
Wei Duan ◽  
Xuetong Qu ◽  
Jianmin Wu
Keyword(s):  
Wound Healing ◽  
Porous Silicon ◽  
On Demand

Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing

2021 ◽  
Vol 403 ◽  
pp. 126182 ◽  
Author(s):  
Bailong Tao ◽  
Chuanchuan Lin ◽  
Zhang Yuan ◽  
Ye He ◽  
Maowen Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Near Infrared ◽  
Composite Hydrogel ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand

scholarly journals Correction to “Injectable and pH-Sensitive Hyaluronic Acid-Based Hydrogels with On-Demand Release of Antimicrobial Peptides for Infected Wound Healing”

2021 ◽  
Author(s):  
Huinan Suo ◽  
Mubashir Hussain ◽  
Hua Wang ◽  
Nuoya Zhou ◽  
Juan Tao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Antimicrobial Peptides ◽  
Ph Sensitive ◽  
Infected Wound ◽  
On Demand

scholarly journals Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 117
Author(s):  
Alexandru Anisiei ◽  
Irina Rosca ◽  
Andreea-Isabela Sandu ◽  
Adrian Bele ◽  
Xinjian Cheng ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antimicrobial Agents ◽  
Dermal Fibroblast ◽  
Intermolecular Forces ◽  
Wound Dressings ◽  
Conversion Degree ◽  
Fiber Morphology ◽  
On Demand ◽  
Vis Spectroscopy

Microporous chitosan nanofibers functionalized with different amounts of an antimicrobial agent via imine linkage were prepared by a three-step procedure including the electrospinning of a chitosan/PEO blend, PEO removal and acid condensation reaction in a heterogeneous system with 2-formylphenylboronic acid. The fibers’ characterization was undertaken keeping in mind their application to wound healing. Thus, by FTIR and 1H-NMR spectroscopy, it was confirmed the successful imination of the fibers and the conversion degree of the amine groups of chitosan into imine units. The fiber morphology in terms of fiber diameter, crystallinity, inter- and intra-fiber porosity and strength of intermolecular forces was investigated using scanning electron microscopy, polarized light microscopy, water vapor sorption and thermogravimetric analysis. The swelling ability was estimated in water and phosphate buffer by calculating the mass equilibrium swelling. The fiber biodegradation was explored in five media of different pH, corresponding to different stages of wound healing and the antimicrobial activity against the opportunistic pathogens inflicting wound infection was investigated according to standard tests. The biocompatibility and bioadhesivity were studied on normal human dermal fibroblast cells by direct contact procedure. The dynamic character of the imine linkage of the functionalized fibers was monitored by UV-vis spectroscopy. The results showed that the functionalization of the chitosan microporous nanofibers with antimicrobial agents via imine linkage is a great route towards bio-absorbable wound dressings with “on demand” antimicrobial properties and biodegradation rate matching the healing stages.

Multifunctional Dynamic Enamine‐Based Hydrogels with On‐Demand Removability for Wound Healing

2021 ◽  
pp. 2101855
Author(s):  
Fanwei Zeng ◽  
Xueyu Jiang ◽  
Hao Zhang ◽  
Minzhang Chen ◽  
Ang Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
On Demand

On-Demand Dissolvable Self-Healing Hydrogel Based on Carboxymethyl Chitosan and Cellulose Nanocrystal for Deep Partial Thickness Burn Wound Healing

2018 ◽  
Vol 10 (48) ◽  
pp. 41076-41088 ◽  
Author(s):  
Weijuan Huang ◽  
Yixiang Wang ◽  
Zhiqiang Huang ◽  
Xiaolan Wang ◽  
Lingyun Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Carboxymethyl Chitosan ◽  
Cellulose Nanocrystal ◽  
Self Healing ◽  
Burn Wound ◽  
On Demand ◽  
Burn Wound Healing ◽  
Partial Thickness ◽  
Partial Thickness Burn

scholarly journals Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles

2021 ◽  
Author(s):  
Tauseef Ahmad ◽  
Sean McGrath ◽  
Catherine Sirafim ◽  
Ronaldo J. F. C. do Amaral ◽  
Shin-Loong Soong ◽  
...  
Keyword(s):  
Wound Healing ◽  
On Demand ◽  
Sequential Release

Collagen-glycosaminoglycan scaffolds are functionalized with alginate that responds to ultrasound by releasing nanoparticles on-demand for coordinated wound healing.

Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

ACS Nano ◽  
2021 ◽  
Vol 15 (4) ◽  
pp. 7078-7093
Author(s):  
Yuqing Liang ◽  
Zhenlong Li ◽  
Ying Huang ◽  
Rui Yu ◽  
Baolin Guo
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Infected Wound ◽  
On Demand
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