Versatile and Simple Strategy for Preparing Bilayer Hydrogels with Janus Characteristics

2022 ◽  
Author(s):  
Xiaomin He ◽  
Shuaibing Wang ◽  
Jiahui Zhou ◽  
Dong Zhang ◽  
Yaoting Xue ◽  
...  
Keyword(s):  
Simple Strategy

A simple strategy for fabricating honeycomb patterns on commercially available polymer film under a wide humidity range

2020 ◽  
Vol 35 (23-24) ◽  
pp. 3210-3221
Author(s):  
Kai Huang ◽  
Qi Cheng ◽  
Honglei Zhang ◽  
Ligang Lin ◽  
Qiying Wang
Keyword(s):  
Polymer Film ◽  
Simple Strategy ◽  
Humidity Range

Abstract

Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

2020 ◽  
Author(s):  
Abhishek Singh ◽  
Reman K. Singh ◽  
G Naresh Patwari
Keyword(s):  
Hydrogen Bonding ◽  
Rational Design ◽  
Biological Molecules ◽  
Conformational Space ◽  
X Ray Crystallography ◽  
Simple Strategy ◽  
Induced Folding ◽  
Π Stacking ◽  
Varying Length ◽  
Dynamics Simulations

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

2020 ◽  
Author(s):  
Abhishek Singh ◽  
Reman K. Singh ◽  
G Naresh Patwari
Keyword(s):  
Hydrogen Bonding ◽  
Rational Design ◽  
Biological Molecules ◽  
Conformational Space ◽  
X Ray Crystallography ◽  
Simple Strategy ◽  
Induced Folding ◽  
Π Stacking ◽  
Varying Length ◽  
Dynamics Simulations

The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

Revealing changes in curcumin bioavailability using vitamin C as an enhancer by HPLC-MS/MS

2019 ◽  
Vol 16 ◽  
Author(s):  
Xufen Dai ◽  
Jiaxue Hao ◽  
Ying Feng ◽  
Jing Wang ◽  
Qiannan Li ◽  
...  
Keyword(s):  
Vitamin C ◽  
High Performance ◽  
Internal Standard ◽  
Fold Increase ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Solution Ph ◽  
Esi Ms ◽  
Simple Strategy ◽  
Isolated Compound

Background: Curcumin (CUR), a natural isolated compound from turmeric, has been the promising star in fighting many diseases but the broad application of curcumin has been limited ascribed to low bioavailability. Objective: The aim of this study is to pursue the enhancement of curcumin bioavailability through co-administration of vitamin C. Methods: Such purpose was achieved through the analysis of curcumin pharmacokinetics by high performance liquid chromatography coupled with electrospray ionization - tandem mass spectrometry (HPLC - ESI - MS/MS). The plasma was separated on a C18 reverse phase column using acetonitrile and ammonium formate solution (pH 6.5; 2.0 mM) at 0.8 mL/min. MS/MS detection was carried out in negative mode using mass patterns of m/z 367.0 > 216.7 for curcumin and m/z 265.2 > 223.9 for internal standard (honokiol). Results: Successful application of the proposed method in the pharmacokinetic study presented clear changes in key pharmacokinetic parameters including the growth of AUC (0-t) up to 2.4 times, 2.2-fold increase of Cmax, 2.2-fold loss of CL, and 1.5-fold diminishment of t1/2. Conclusion: We developed an HPLC-ESI-MS/MS method for determination of curcumin in rat plasma and validated the improvement of bioavailability of curcumin through co-administration of vitamin C. We reasoned these changes to the inhibition of lipid peroxidation induced by the use of vitamin C. Such a simple strategy is possible to become an alternative for enhancing curcumin efficiency in practice.

A simple strategy increases mothers’ knowledge of breastfeeding and improves the breastfeeding rates

1998 ◽  
Vol 74 (5) ◽  
pp. 368-76 ◽  
Author(s):  
Lulie R.O. Susin ◽  
Elsa R. J. Giugliani ◽  
Suzane C. Kummer ◽  
Marileide Maciel ◽  
Ana C. W. Benjamin ◽  
...  
Keyword(s):  
Simple Strategy ◽  
Breastfeeding Rates

A simple strategy based on photobiotin irradiation for the photoelectrochemical immobilization of proteins on electrode surfaces

2006 ◽  
Vol 26 (2-3) ◽  
pp. 436-441 ◽  
Author(s):  
Serge Cosnier ◽  
Carmen Molins ◽  
Christine Mousty ◽  
Bruno Galland ◽  
Arielle Lepellec
Keyword(s):  
Electrode Surfaces ◽  
Simple Strategy

scholarly journals A Novel Quinoxaline-Rhodamine Conjugate for a Simple and Efficient Detection of Hydrogen Sulphate Ion

Compounds ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 29-40
Author(s):  
Sutapa Sahu ◽  
Yeasin Sikdar ◽  
Riya Bag ◽  
Dilip K. Maiti ◽  
José P. Cerón-Carrasco ◽  
...  
Keyword(s):  
Solid Phase ◽  
Detection Limits ◽  
Hydrogen Sulfate ◽  
Absorption And Emission ◽  
Conjugate System ◽  
Colorimetric Chemosensor ◽  
Simple Strategy ◽  
Efficient Detection ◽  
Hydrogen Sulphate

This work presents the development of a quinoxaline and rhodamine conjugate system that acts as a colorimetric chemosensor for hydrogen sulfate (HSO4−) ions in methanol media. This sensor has been characterized both theoretically and experimentally. The detection limits for HSO4− are small as 0.71 µM and 3.8 µM for the absorption and emission experiments, respectively. The effectiveness of the probe in recognizing HSO4− both in gel and solid phase is evaluated as well. Thus, this works presents a simple strategy to detect the environmental HSO4− pollutant event at tiny concentrations.

scholarly journals Cyclometalated iridium–BODIPY ratiometric O2 sensors

2019 ◽  
Vol 10 (19) ◽  
pp. 5124-5132 ◽  
Author(s):  
Ku Sun Choung ◽  
Karen Marroquin ◽  
Thomas S. Teets
Keyword(s):  
Molecular Oxygen ◽  
Simple Strategy ◽  
Ratiometric Sensors

Cyclometalated iridium–BODIPY conjugates are prepared by a simple strategy and are effective ratiometric sensors for molecular oxygen.

-ADIC -FUNCTIONS FOR ORDINARY FAMILIES ON SYMPLECTIC GROUPS

2019 ◽  
Vol 19 (4) ◽  
pp. 1287-1347 ◽  
Author(s):  
Zheng Liu
Keyword(s):  
Eisenstein Series ◽  
Symplectic Group ◽  
Symplectic Groups ◽  
Simple Strategy ◽  
Doubling Method

We construct the $p$-adic standard $L$-functions for ordinary families of Hecke eigensystems of the symplectic group $\operatorname{Sp}(2n)_{/\mathbb{Q}}$ using the doubling method. We explain a clear and simple strategy of choosing the local sections for the Siegel Eisenstein series on the doubling group $\operatorname{Sp}(4n)_{/\mathbb{Q}}$, which guarantees the nonvanishing of local zeta integrals and allows us to $p$-adically interpolate the restrictions of the Siegel Eisenstein series to $\operatorname{Sp}(2n)_{/\mathbb{Q}}\times \operatorname{Sp}(2n)_{/\mathbb{Q}}$.

scholarly journals Hunting wino and higgsino dark matter at the muon collider with disappearing tracks

2021 ◽  
Vol 2021 (6) ◽  
Author(s):  
Rodolfo Capdevilla ◽  
Federico Meloni ◽  
Rosa Simoniello ◽  
Jose Zurita
Keyword(s):  
Dark Matter ◽  
Simple Strategy ◽  
Physics Program ◽  
Daunting Task ◽  
Muon Collider ◽  
New States ◽  
Muon Colliders ◽  
Particle Decays ◽  
Electrically Charged

Abstract We study the capabilities of a muon collider experiment to detect disappearing tracks originating when a heavy and electrically charged long-lived particle decays via X+→ Y+Z0, where X+ and Z0 are two almost mass degenerate new states and Y+ is a charged Standard Model particle. The backgrounds induced by the in-flight decays of the muon beams (BIB) can create detector hit combinations that mimic long-lived particle signatures, making the search a daunting task. We design a simple strategy to tame the BIB, based on a detector-hit-level selection exploiting timing information and hit-to-hit correlations, followed by simple requirements on the quality of reconstructed tracks. Our strategy allows us to reduce the number of tracks from BIB to an average of 0.08 per event, hence being able to design a cut-and-count analysis that shows that it is possible to cover weak doublets and triplets with masses close to $$ \sqrt{s}/2 $$ s / 2 in the 0.1–10 ns range. In particular, this implies that a 10 TeV muon collider is able to probe thermal MSSM higgsinos and thermal MSSM winos, thus rivaling the FCC-hh in that respect, and further enlarging the physics program of the muon collider into the territory of WIMP dark matter and long-lived signatures. We also provide parton-to-reconstructed level efficiency maps, allowing an estimation of the coverage of disappearing tracks at muon colliders for arbitrary models.

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