Tumor-Activated Water-Soluble Photosensitizers for Near-Infrared Photodynamic Cancer Therapy

2018 ◽  
Vol 10 (19) ◽  
pp. 16335-16343 ◽  
Author(s):  
Hu Xiong ◽  
Kejin Zhou ◽  
Yunfeng Yan ◽  
Jason B. Miller ◽  
Daniel J. Siegwart
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Water Soluble ◽  
Photodynamic Cancer Therapy

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

Triphenylamine flanked furan-diketopyrrolopyrrole for multi-imaging guided photothermal/photodynamic cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18890-18896 ◽  
Author(s):  
Pingping Liang ◽  
Ya Wang ◽  
Peng Wang ◽  
Jianhua Zou ◽  
Hong Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photodynamic Cancer Therapy ◽  
Donor Acceptor ◽  
Photothermal Imaging

A near-infrared donor–acceptor–donor agent of triphenylamine flanked furan-diketopyrrolopyrrole nanoparticles is designed and synthesized for fluorescence, photoacoustic and photothermal imaging guided synergistic photodynamic and photothermal therapy (PDT/PTT).

scholarly journals Near-Infrared Fluorescent pH Responsive Probe for Targeted Photodynamic Cancer Therapy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Siriwalee Siriwibool ◽  
Nantawat Kaekratoke ◽  
Kantapat Chansaenpak ◽  
Kittipan Siwawannapong ◽  
Pannipa Panajapo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Ph Responsive ◽  
Photodynamic Cancer Therapy

Near-Infrared-Absorbing Gold Nanopopcorns with Iron Oxide Cluster Core for Magnetically Amplified Photothermal and Photodynamic Cancer Therapy

2015 ◽  
Vol 7 (21) ◽  
pp. 11637-11647 ◽  
Author(s):  
Saheel Bhana ◽  
Gan Lin ◽  
Lijia Wang ◽  
Hunter Starring ◽  
Sanjay R. Mishra ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Near Infrared ◽  
Cluster Core ◽  
Oxide Cluster ◽  
Photodynamic Cancer Therapy

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy

2018 ◽  
Vol 15 (7) ◽  
pp. 2594-2605 ◽  
Author(s):  
Hoay Yan Cheah ◽  
Elena Gallon ◽  
Fabienne Dumoulin ◽  
See Ziau Hoe ◽  
Nina Japundžić-Žigon ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Glutamic Acid ◽  
Near Infrared ◽  
Antitumor Efficacy ◽  
Photodynamic Cancer Therapy ◽  
Acid Conjugate

A charge-switchable, four-armed polymeric photosensitizer for photodynamic cancer therapy

2014 ◽  
Vol 50 (33) ◽  
pp. 4354-4357 ◽  
Author(s):  
Chung-Sung Lee ◽  
Wooram Park ◽  
Young Um Jo ◽  
Kun Na
Keyword(s):  
Cancer Therapy ◽  
Water Soluble ◽  
New Class ◽  
Photodynamic Cancer Therapy ◽  
Ph Dependent ◽  
A Charge

A water-soluble, charge-switchable, four-armed polymeric photosensitizer (C4P-PS), in which charge switching is pH dependent, has been designed as a new class of photosensitizer for photodynamic cancer therapy.

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