Anti-Inflammation and Joint Lubrication Dual Effects of a Novel Hyaluronic Acid/Curcumin Nanomicelle Improve the Efficacy of Rheumatoid Arthritis Therapy

2018 ◽  
Vol 10 (28) ◽  
pp. 23595-23604 ◽  
Author(s):  
Zengjie Fan ◽  
Jie Li ◽  
Jianli Liu ◽  
Hongjing Jiao ◽  
Bin Liu
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Joint Lubrication ◽  
Anti Inflammation

scholarly journals Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Wei Zhang ◽  
Guoyu Yin ◽  
Heping Zhao ◽  
Hanzhi Ling ◽  
Zhen Xie ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Dependent Manner ◽  
Collagen Induced Arthritis ◽  
Intracellular Degradation ◽  
Main Pathway ◽  
First Time

AbstractIn inflamed joints, enhanced hyaluronic acid (HA) degradation is closely related to the pathogenesis of rheumatoid arthritis (RA). KIAA1199 has been identified as a hyaladherin that mediates the intracellular degradation of HA, but its extracellular function remains unclear. In this study, we found that the serum and synovial levels of secreted KIAA1199 (sKIAA1199) and low-molecular-weight HA (LMW-HA, MW < 100 kDa) in RA patients were significantly increased, and the positive correlation between them was shown for the first time. Of note, treatment with anti-KIAA1199 mAb effectively alleviated the severity of arthritis and reduced serum LMW-HA levels and cytokine secretion in collagen-induced arthritis (CIA) mice. In vitro, sKIAA1199 was shown to mediate exogenous HA degradation by attaching to the cell membrane of RA fibroblast-like synoviosytes (RA FLS). Furthermore, the HA-degrading activity of sKIAA1199 depended largely on its adhesion to the membrane, which was achieved by its G8 domain binding to ANXA1. In vivo, kiaa1199-KO mice exhibited greater resistance to collagen-induced arthritis. Interestingly, this resistance could be partially reversed by intra-articular injection of vectors encoding full-length KIAA1199 instead of G8-deleted KIAA119 mutant, which further confirmed the indispensable role of G8 domain in KIAA1199 involvement in RA pathological processes. Mechanically, the activation of NF-κB by interleukin-6 (IL-6) through PI3K/Akt signaling is suggested to be the main pathway to induce KIAA1199 expression in RA FLS. In conclusion, our study supported the contribution of sKIAA1199 to RA pathogenesis, providing a new therapeutic target for RA by blocking sKIAA1199-mediated HA degradation.

scholarly journals Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 321
Author(s):  
Shenghui Zhong ◽  
Peng Liu ◽  
Jinsong Ding ◽  
Wenhu Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
High Dose ◽  
One Pot ◽  
Inflammatory Site ◽  
Pei Nanoparticles ◽  
Toxic Reactions

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.

scholarly journals Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression

2016 ◽  
Vol 9 (1) ◽  
pp. 15-23
Author(s):  
SAID AL-DALAEN ◽  
AIMAN AL-QTAITAT ◽  
MOHAMMAD AL-RAWASHDEH ◽  
JIHAD ALZYOUD ◽  
AIMAN AL-MAATHADI
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Disease Progression ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
And Cartilage

Paper 7: Properties of Synovial Fluid

1966 ◽  
Vol 181 (10) ◽  
pp. 25-29 ◽  
Author(s):  
D. V. Davies
Keyword(s):  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Normal Animal ◽  
Chemical Components ◽  
Weissenberg Rheogoniometer ◽  
Nutritive Medium ◽  
Shear Rates ◽  
Joint Lubrication ◽  
Normal Human ◽  
Human Joints

Synovial fluid functions both as a lubricant and as a nutritive medium in joints. Its chemical composition suggests that it is a dialysate of blood plasma with the addition of the mucosubstance, hyaluronic acid. In addition the fluid contains a small cellular component. The quantities of some of the chemical components are apparently anomalous and need explanation. The hyaluronic acid, probably combined with a small amount of protein, is believed to be secreted by the cells lining the joint cavity, the synovial cells. The volume and naked eye appearance of the fluid vary from joint to joint in the same species and in the same joint from species to species. The volume of fluid that can be aspirated from normal human joints is too small for most chemical and physical investigations and recourse must be made to fluids from the larger domestic animals and to pathological human fluids. The most characteristic property of the fluid is its viscosity. This has been investigated using the Weissenberg rheogoniometer. This allows of a study of the viscosity and elasticity of the fluids at different shear rates. Results on fluid from both normal animal joints and pathological human joints will be presented. Their relevance in joint lubrication will be discussed.

ASSOCIATION OF SERUM LEVELS OF HYALURONIC ACID (HA) WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

2006 ◽  
Vol 12 (Supplement) ◽  
pp. S36
Author(s):  
C Palafox-S??nchez ◽  
I Garc??a-Valladares ◽  
D O Taylor ◽  
L R L??pez ◽  
Garc??a De La Torre Ignacio
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Disease Activity ◽  
Serum Levels

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

2014 ◽  
Vol 50 (57) ◽  
pp. 7632 ◽  
Author(s):  
Jung Min Shin ◽  
Seol-Hee Kim ◽  
Thavasyappan Thambi ◽  
Dong Gil You ◽  
Jueun Jeon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Therapy

The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication

Soft Matter ◽  
2015 ◽  
Vol 11 (13) ◽  
pp. 2596-2603 ◽  
Author(s):  
Zhenhuan Zhang ◽  
Gordon F. Christopher
Keyword(s):  
Hyaluronic Acid ◽  
Nonlinear Viscoelasticity ◽  
Joint Lubrication

scholarly journals Hyaluronic acid attenuates expression of HIF‐1 alpha and iNOS in experimental rheumatoid arthritis

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Pei‐Lin Chang ◽  
Yueh‐Ling Hsieh ◽  
Pin‐Wen Tu ◽  
Li‐Wei Chou ◽  
Hsiu‐Chung Ou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid

scholarly journals Serum and urine levels of hyaluronic acid in rheumatoid arthritis.

Ensho ◽  
1996 ◽  
Vol 16 (2) ◽  
pp. 97-102
Author(s):  
Manabu Tanabe ◽  
Kae Ishiyama ◽  
Akira Suwa ◽  
Takashi Yamada ◽  
Shin-ichi Inada ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Urine Levels ◽  
Serum And Urine
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