The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication

Soft Matter ◽  
2015 ◽  
Vol 11 (13) ◽  
pp. 2596-2603 ◽  
Author(s):  
Zhenhuan Zhang ◽  
Gordon F. Christopher
Keyword(s):  
Hyaluronic Acid ◽  
Nonlinear Viscoelasticity ◽  
Joint Lubrication

Anti-Inflammation and Joint Lubrication Dual Effects of a Novel Hyaluronic Acid/Curcumin Nanomicelle Improve the Efficacy of Rheumatoid Arthritis Therapy

2018 ◽  
Vol 10 (28) ◽  
pp. 23595-23604 ◽  
Author(s):  
Zengjie Fan ◽  
Jie Li ◽  
Jianli Liu ◽  
Hongjing Jiao ◽  
Bin Liu
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Joint Lubrication ◽  
Anti Inflammation

Paper 7: Properties of Synovial Fluid

1966 ◽  
Vol 181 (10) ◽  
pp. 25-29 ◽  
Author(s):  
D. V. Davies
Keyword(s):  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Normal Animal ◽  
Chemical Components ◽  
Weissenberg Rheogoniometer ◽  
Nutritive Medium ◽  
Shear Rates ◽  
Joint Lubrication ◽  
Normal Human ◽  
Human Joints

Synovial fluid functions both as a lubricant and as a nutritive medium in joints. Its chemical composition suggests that it is a dialysate of blood plasma with the addition of the mucosubstance, hyaluronic acid. In addition the fluid contains a small cellular component. The quantities of some of the chemical components are apparently anomalous and need explanation. The hyaluronic acid, probably combined with a small amount of protein, is believed to be secreted by the cells lining the joint cavity, the synovial cells. The volume and naked eye appearance of the fluid vary from joint to joint in the same species and in the same joint from species to species. The volume of fluid that can be aspirated from normal human joints is too small for most chemical and physical investigations and recourse must be made to fluids from the larger domestic animals and to pathological human fluids. The most characteristic property of the fluid is its viscosity. This has been investigated using the Weissenberg rheogoniometer. This allows of a study of the viscosity and elasticity of the fluids at different shear rates. Results on fluid from both normal animal joints and pathological human joints will be presented. Their relevance in joint lubrication will be discussed.

scholarly journals Role of hyaluronic acid in joint lubrication.

1974 ◽  
Vol 33 (4) ◽  
pp. 318-326 ◽  
Author(s):  
D A Swann ◽  
E L Radin ◽  
M Nazimiec ◽  
P A Weisser ◽  
N Curran ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Joint Lubrication

269: Increasing the Fish Detection of Urothelial Bladder Carcinoma - A Brazilian Experience Comparing with BTA Stat, Hyaluronic Acid and Cytology in Voided Urine Specimes

2004 ◽  
Vol 171 (4S) ◽  
pp. 71-71 ◽  
Author(s):  
Alexandre Bomfim ◽  
Miguel Srougi ◽  
Gilka Gattas ◽  
Katia R. Leite ◽  
Luiz H. Camara-Lopes ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bladder Carcinoma ◽  
Urothelial Bladder Carcinoma ◽  
Urothelial Bladder ◽  
Fish Detection ◽  
Bta Stat

Hyaluronic acid as a marker of disease progression in chronic hepatitis

2001 ◽  
Vol 34 (0) ◽  
pp. 166
Author(s):  
G Shiha
Keyword(s):  
Chronic Hepatitis ◽  
Hyaluronic Acid ◽  
Disease Progression

Clinical effectiveness of bulking agent hyaluronic acid/dextranomer (Urodex)

2011 ◽  
Vol 71 (10) ◽  
Author(s):  
I Apolikhina ◽  
A Saidova
Keyword(s):  
Hyaluronic Acid ◽  
Clinical Effectiveness ◽  
Bulking Agent

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

Nonsurgical Treatment of Abnormal Eyelid Position Using Hyaluronic Acid Gel

2012 ◽  
Vol 53 (3) ◽  
pp. 357
Author(s):  
Seok Joong Chung ◽  
Hyun Min Shin ◽  
Helen Lew
Keyword(s):  
Hyaluronic Acid ◽  
Nonsurgical Treatment ◽  
Acid Gel ◽  
Hyaluronic Acid Gel
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