DNA-Based Nanomedicine with Targeting and Enhancement of Therapeutic Efficacy of Breast Cancer Cells

2019 ◽  
Vol 11 (17) ◽  
pp. 15354-15365 ◽  
Author(s):  
Yuxi Zhan ◽  
Wenjuan Ma ◽  
Yuxin Zhang ◽  
Chenchen Mao ◽  
Xiaoru Shao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells

Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer

2020 ◽  
Vol 8 (31) ◽  
pp. 6837-6844
Author(s):  
Xuechen Qian ◽  
Yinjie Wang ◽  
Youfeng Xu ◽  
Ling Ma ◽  
Nianyu Xue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Ultrasound Irradiation ◽  
Active Targeting ◽  
Receptor Ligand ◽  
Y1 Receptor ◽  
Nano Scale

Y1 receptor ligand-modified nanobubbles could target breast cancer cells and improve therapeutic efficacy with reduced side effects under ultrasound irradiation during chemotherapy.

scholarly journals Preparation of chitosan‑silicon dioxide/BCSG1‑siRNA nanoparticles to enhance therapeutic efficacy in breast cancer cells

2017 ◽  
Author(s):  
Lan Cui ◽  
Ruifeng Zheng ◽  
Wentao Liu ◽  
Peihong Shen ◽  
Youcai Tang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silicon Dioxide ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells

scholarly journals Therapeutic efficacy of Genistein-Cytoreg® combination in breast cancer cells

2012 ◽  
Vol 2 (5) ◽  
pp. 137
Author(s):  
M. M. Johnson ◽  
K. J. Kumi-Diaka ◽  
R. Zoeller ◽  
B. S. Graves ◽  
K. T. Merchant ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Combination Treatment ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Human Breast ◽  
Trypan Blue Exclusion ◽  
Normal Human Breast ◽  
Mcf 7

Background: In spite the heavy investments in therapeutic research breast cancer still impacts the lives of women globally. The projected incidence of new cases of in situ breast cancer in the USA for 2011 is 57,650, with estimated 39,520 deaths. The phytoestrogen, genistein and the synthetic compound, Cytoreg® have been shown to inhibit growth and proliferation in many cancer cell lines. Purpose of the Study: In this study, we investigated the therapeutic efficacy of Cytoreg®-genistein combination on growth inhibition in the MCF-7 human breast cancer cells. Method: MCF-7 cells were treated with genistein and Cytoreg® single and combination treatments for 24-48hrs; and post treatment chemosensitivity assessed, using: Trypan Blue exclusion and MTT assays for cell viability, Ethidium bromide/Acridine orange to assess apoptosis induction, and FAM Poly-Caspase binding assay for mechanism of action. Results: The overall data indicated dose- and time-dependent cell death in the MCF-cells and apoptosis as the major means of treatment-induced growth inhibition with all the treatment regimens. Conclusion: Comparatively, the genistein-Cytoreg® combination treatment was significantly more efficacious in growth inhibition in the MCF cells than either genistein or Cytoreg® alone. Genistein seems to act additively with Cytoreg® in combination treatment-induced apoptosis in MCF-7 cells. The normal human breast epithelial cells were not significantly inhibited by either single or the combination treatments.Key words: Cytoreg®, Genistein, Combination treatment, MCF- cancer cells, apoptosis

scholarly journals Enhancing the Therapeutic Efficacy of 2-Deoxyglucose in Breast Cancer Cells Using Cell-cycle Synchronization

2016 ◽  
Vol 36 (11) ◽  
pp. 5975-5980 ◽  
Author(s):  
SU JIN LEE ◽  
BOK-NAM PARK ◽  
JUNG HYUN ROH ◽  
YOUNG-SIL AN ◽  
HOON HUR ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Cell Cycle Synchronization

scholarly journals Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mengjun Shu ◽  
Feng Gao ◽  
Min Zeng ◽  
Chulang Yu ◽  
Xue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Antitumour Activity ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Microwave Assisted ◽  
Intracellular Drug Delivery

AbstractTo achieve better antitumour efficacy, it is urgent to improve anticancer drug delivery efficiency in targeting cancer cells. In this work, chitosan-functionalized graphene oxide (ChrGO) nanosheets were fabricated via microwave-assisted reduction, which were employed to the intracellular delivery nanosystem for anticancer drug agent in breast cancer cells. Drug loading and release research indicated that adriamycin can be efficiently loaded on and released from the ChrGO nanosheets. Less drug release during delivery and better biocompatibility of ChrGO/adriamycin significantly improve its safety and therapeutic efficacy in HER2-overexpressing BT-474 cells. Furthermore, ChrGO/adriamycin in combination with trastuzumab exhibited synergistic antitumour activity in BT-474 cells, which demonstrated superior therapeutic efficacy compared with each drug alone. Cells treated with trastuzumab (5 μg/mL) or equivalent ChrGO/adriamycin (5 μg/mL) each elicited 54.5% and 59.5% cell death, respectively, while the combination treatment with trastuzumab and ChrGO/adriamycin resulted in a dramatic 88.5% cell death. The dual-targeted therapy displayed higher apoptosis, indicating superior therapeutic efficacy due to the presence of different mechanisms of action. The combined treatment of ChrGO/adriamycin and trastuzumab in BT-474 cells induced cell cycle arrest and apoptosis, which ultimately led to the death of augmented cancer cells. This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.

scholarly journals Gef gene therapy enhances the therapeutic efficacy of doxorubicin to combat growth of MCF-7 breast cancer cells

2009 ◽  
Vol 66 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Jose Prados ◽  
Consolación Melguizo ◽  
Ana Rosa Rama ◽  
Rául Ortiz ◽  
Ana Segura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Mcf 7

Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells

2011 ◽  
Vol 112 (4) ◽  
pp. 1103-1117 ◽  
Author(s):  
Józefa Węsierska-Gądek ◽  
David Gritsch ◽  
Nora Zulehner ◽  
Oxana Komina ◽  
Margarita Maurer
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Cdk Inhibitor ◽  
Er Positive ◽  
Positive Breast Cancer

Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells

2017 ◽  
Vol 9 (42) ◽  
pp. 36493-36512 ◽  
Author(s):  
Mahaveer P. Purohit ◽  
Neeraj K. Verma ◽  
Aditya K. Kar ◽  
Amrita Singh ◽  
Debabrata Ghosh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Thioredoxin Reductase ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals H-Ferritin Enriches the Curcumin Uptake and Improves the Therapeutic Efficacy in Triple Negative Breast Cancer Cells

2017 ◽  
Vol 18 (10) ◽  
pp. 3318-3330 ◽  
Author(s):  
Laura Pandolfi ◽  
Michela Bellini ◽  
Renzo Vanna ◽  
Carlo Morasso ◽  
Andrea Zago ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Triple Negative
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