Differential Interference Contrast-Based Interrogation of Plasmonic Gold Nanohole Arrays for Label-Free Imaging Sensing

2021 ◽  
Author(s):  
Ying Zhu ◽  
Peter J. Reece
Keyword(s):  
Differential Interference Contrast ◽  
Label Free ◽  
Nanohole Arrays

Passivated Aluminum Nanohole Arrays for Label-Free Biosensing Applications

2013 ◽  
Vol 6 (2) ◽  
pp. 1005-1010 ◽  
Author(s):  
Víctor Canalejas-Tejero ◽  
Sonia Herranz ◽  
Alyssa Bellingham ◽  
María Cruz Moreno-Bondi ◽  
Carlos Angulo Barrios
Keyword(s):  
Label Free ◽  
Nanohole Arrays

scholarly journals Metallic Nanohole Arrays on Fluoropolymer Substrates as Small Label-Free Real-Time Bioprobes

Nano Letters ◽  
2008 ◽  
Vol 8 (9) ◽  
pp. 2718-2724 ◽  
Author(s):  
Jiun-Chan Yang ◽  
Jin Ji ◽  
James M. Hogle ◽  
Dale N. Larson
Keyword(s):  
Real Time ◽  
Label Free ◽  
Nanohole Arrays

Plasmonic nanohole arrays for label-free kinetic biosensing in a lipid membrane environment

2009 ◽  
Author(s):  
A. Lesuffleur ◽  
Kwan Seop Lim ◽  
N.C. Lindquist ◽  
Hyungsoon Im ◽  
A.E. Warrington ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Label Free ◽  
Nanohole Arrays

Biosensing using plasmonic nanohole arrays with small, homogenous and tunable aperture diameters

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3803-3810 ◽  
Author(s):  
Kunli Xiong ◽  
Gustav Emilsson ◽  
Andreas B. Dahlin
Keyword(s):  
Molecular Detection ◽  
Label Free ◽  
Nanohole Arrays

Plasmonic nanohole arrays are widely used for optical label-free molecular detection.

scholarly journals Label-free high-speed wide-field imaging of single microtubules using interference reflection microscopy

2018 ◽  
Author(s):  
Mohammed Mahamdeh ◽  
Steve Simmert ◽  
Anna Luchniak ◽  
Erik Schäeffer ◽  
Jonathon Howard
Keyword(s):  
High Speed ◽  
Signal To Noise Ratio ◽  
Dark Field ◽  
Fluorescent Labeling ◽  
Wide Field ◽  
Differential Interference Contrast ◽  
Label Free ◽  
High Speed Imaging ◽  
Highly Sensitive

SummaryWhen studying microtubules in vitro, label free imaging of single microtubules is necessary when the quantity of purified tubulin is too low for efficient fluorescent labeling or there is concern that labelling will disrupt its function. Commonly used techniques for observing unlabeled microtubules, such as video enhanced differential interference contrast, dark-field and more recently laser-based interferometric scattering microscopy, suffer from a number of drawbacks. The contrast of differential interference contrast images depends on the orientation of the microtubules, dark-field is highly sensitive to impurities and optical misalignments, and interferometric scattering has a limited field of view. In addition, all of these techniques require costly optical components such as Nomarski prisms, dark-field condensers, lasers and laser scanners. Here we show that single microtubules can be imaged at high speed and with high contrast using interference reflection microscopy without the aforementioned drawbacks. Interference reflection microscopy is simple to implement, requiring only the incorporation of a 50/50 mirror instead of a dichroic in a fluorescence microscope, and with appropriate microscope settings has similar signal-to-noise ratio to differential interference contrast and fluorescence. We demonstrated the utility of interference reflection microscopy by high speed imaging and tracking of dynamic microtubules at 100 frames per second. In conclusion, the image quality of interference reflection microscopy is similar to or exceeds that of all other techniques and, with minimal microscope modification, can be used to study the dynamics of unlabeled microtubules.

scholarly journals Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

Sensors ◽  
2013 ◽  
Vol 13 (10) ◽  
pp. 13960-13968 ◽  
Author(s):  
Josu Martinez-Perdiguero ◽  
Aritz Retolaza ◽  
Deitze Otaduy ◽  
Aritz Juarros ◽  
Santos Merino
Keyword(s):  
Free Surface ◽  
Surface Plasmon Resonance ◽  
Real Time ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Nanoimprint Lithography ◽  
Label Free ◽  
Nanohole Arrays

scholarly journals Rayleigh anomaly-enabled mode hybridization in gold nanohole arrays by scalable colloidal lithography for highly-sensitive biosensing

Nanophotonics ◽  
2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhiliang Zhang ◽  
Feng Zhao ◽  
Renxian Gao ◽  
Chih-Yu Jao ◽  
Churong Ma ◽  
...  
Keyword(s):  
Refractive Index ◽  
Plasmonic Nanostructures ◽  
Label Free ◽  
Colloidal Lithography ◽  
Large Area ◽  
Nanohole Array ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Nanohole Arrays ◽  
Rayleigh Anomaly

Abstract Plasmonic sensors exhibit tremendous potential to accomplish real-time, label-free, and high-sensitivity biosensing. Gold nanohole array (GNA) is one of the classic plasmonic nanostructures that can be readily fabricated and integrated into microfluidic platforms for a variety of applications. Even though GNA has been widely studied, new phenomena and applications are still emerging continuously expanding its capabilities. In this article, we demonstrated narrow-band high-order resonances enabled by Rayleigh anomaly in the nanohole arrays that are fabricated by scalable colloidal lithography. We fabricated large-area GNAs with different hole diameters, and investigated their transmission characteristics both numerically and experimentally. We showed that mode hybridization between the plasmon mode of the nanoholes and Rayleigh anomaly of the array could give rise to high-quality decapole resonance with a unique nearfield profile. We experimentally achieved a refractive index sensitivity, i.e., RIS up to 407 nm/RIU. More importantly, we introduced a spectrometer-free refractive index sensing based on lens-free smartphone imaging of GNAs with (intensity) sensitivity up to 137%/RIU. Using this platform, we realized the label-free detection of BSA molecules with concentration as low as 10−8 M. We believe our work could pave the way for highly sensitive and compact point-of-care devices with cost-effective and high-throughput plasmonic chips.

Aluminum Nanohole Arrays Fabricated on Polycarbonate for Compact Disc-Based Label-Free Optical Biosensing

Plasmonics ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 645-649 ◽  
Author(s):  
C. A. Barrios ◽  
V. Canalejas-Tejero ◽  
S. Herranz ◽  
M. C. Moreno-Bondi ◽  
M. Avella-Oliver ◽  
...  
Keyword(s):  
Compact Disc ◽  
Label Free ◽  
Optical Biosensing ◽  
Nanohole Arrays

Chiral nanohole arrays

Nanoscale ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 2479-2491 ◽  
Author(s):  
Bin Ai ◽  
Hoang M. Luong ◽  
Yiping Zhao
Keyword(s):  
Label Free ◽  
Nanohole Array ◽  
Drug Molecules ◽  
Nanohole Arrays

Ultra-thin chiral nanohole array films are fabricated by a simple and efficient shadow sphere lithography (SSL) method and achieve label-free enantiodiscrimination of biomolecules and drug molecules at the picogram level.

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