Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation

2017 ◽  
Vol 12 (5) ◽  
pp. 1353-1362 ◽  
Author(s):  
Kellie A. Woll ◽  
Wesley Peng ◽  
Qiansheng Liang ◽  
Lianteng Zhi ◽  
Jack A. Jacobs ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Channel Modulation ◽  
Mechanistic Insight ◽  
Inhalational Anesthetic ◽  
Insight Into ◽  
Photoaffinity Ligand

scholarly journals Modulation of the serotonin-sensitive potassium channel in Aplysia sensory neurone cell body and growth cone

1986 ◽  
Vol 124 (1) ◽  
pp. 287-306
Author(s):  
S. A. Siegelbaum ◽  
F. Belardetti ◽  
J. S. Camardo ◽  
M. J. Shuster
Keyword(s):  
Cyclic Amp ◽  
Potassium Channel ◽  
Direct Evidence ◽  
Single Channel ◽  
Growth Cones ◽  
Single Channel Recording ◽  
Sensory Neurone ◽  
Sensory Neurones ◽  
Channel Modulation ◽  
Insight Into

Using single-channel recording, we have been able to obtain some insight into the molecular mechanism of a modulatory transmitter action in Aplysia sensory neurones. Our results show that serotonin produces a slow EPSP and increases action potential duration in the sensory neurones by producing prolonged closures of the S potassium channel. Such closures appear to be mediated by cyclic AMP-dependent phosphorylation of a membrane protein which may be the channel. Modulation of S channels by serotonin also occurs in sensory neurone growth cones. This provides the first direct evidence that channel modulation occurs in nerve processes and increases the likelihood of channel modulation at the nerve terminal.

scholarly journals How an intrinsic ligand tunes the activity of a potassium channel

2018 ◽  
Vol 150 (4) ◽  
pp. 517-520 ◽  
Author(s):  
Keith K. Khoo ◽  
Stephan A. Pless
Keyword(s):  
Ion Channels ◽  
Potassium Channel ◽  
New Work ◽  
Mechanistic Insight ◽  
Insight Into

Khoo and Pless examine new work that provides mechanistic insight into the role of the intrinsic ligand in KCNH ion channels.​

NAD+ supplementation normalises central carbon metabolism in skeletal muscle: a mechanistic insight into the energetic consequences of age-related NAD+ decline

2016 ◽  
Author(s):  
Lucy Oldacre-Bartley ◽  
Rachel Fletcher ◽  
Kate Hollinshead ◽  
Yasir Elhassan ◽  
Craig Doig ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Carbon Metabolism ◽  
Central Carbon Metabolism ◽  
Mechanistic Insight ◽  
Age Related ◽  
Central Carbon ◽  
Insight Into

New Insights on KCa3.1 Channel Modulation

2020 ◽  
Vol 26 (18) ◽  
pp. 2096-2101
Author(s):  
Giuseppe Manfroni ◽  
Francesco Ragonese ◽  
Lorenzo Monarca ◽  
Andrea Astolfi ◽  
Loretta Mancinelli ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Critical Role ◽  
Calcium Signalling ◽  
Typical Feature ◽  
Open Probability ◽  
Pharmacological Agents ◽  
Channel Modulation ◽  
Calcium Dependent ◽  
Modelling Techniques ◽  
Calcium Activated Potassium Channel

The human intermediate conductance calcium-activated potassium channel, KCa3.1, is involved in several pathophysiological conditions playing a critical role in cell secretory machinery and calcium signalling. The recent cryo-EM analysis provides new insights for understanding the modulation by both endogenous and pharmacological agents. A typical feature of this channel is the low open probability in saturating calcium concentrations and its modulation by potassium channel openers (KCOs), such as benzo imidazolone 1-EBIO, without changing calcium-dependent activation. In this paper, we proposed a model of KCOs action in the modulation of channel activity. The KCa3.1 channel has a very rich pharmacological profile with several classes of molecules that selectively interact with different binding sites of the channel. Among them, benzo imidazolones can be openers (positive modulators such as 1-EBIO, DC-EBIO) or blockers (negative modulators such as NS1619). Through computation modelling techniques, we identified the 1,4-benzothiazin-3-one as a promising scaffold to develop new KCa3.1 channel modulators. Further studies are needed to explore the potential use of 1-4 benzothiazine- 3-one in KCa3.1 modulation and its pharmacological application.

scholarly journals Mechanistic insight into B(C6F5)3 catalyzed imine reduction with PhSiH3 under stoichiometric water conditions

RSC Advances ◽  
2021 ◽  
Vol 11 (34) ◽  
pp. 20961-20969
Author(s):  
Yunqing He ◽  
Wanli Nie ◽  
Ying Xue ◽  
Qishan Hu
Keyword(s):  
Mechanistic Insight ◽  
Excess Water ◽  
Water Conditions ◽  
Imine Reduction ◽  
Water Amount ◽  
Insight Into

Hydrosilylation or amination products? It depends on water amount and nucleophiles like excess water or produced/added amines.

Mechanistic insight into the reaction pathway of peroxomonosulfate-initiated decomplexation of EDTA-NiII under alkaline conditions: Formation of high-valent Ni intermediate

2021 ◽  
pp. 120375
Author(s):  
Sheng Liang ◽  
Xiaoting Hu ◽  
Haolin Xu ◽  
Zhenchao Lei ◽  
Chaohai Wei ◽  
...  
Keyword(s):  
Reaction Pathway ◽  
Mechanistic Insight ◽  
Alkaline Conditions ◽  
High Valent ◽  
Insight Into

scholarly journals Mechanistic insight into the fluorescence activity of forensic fingerprinting reagents

2021 ◽  
Vol 154 (12) ◽  
pp. 124313
Author(s):  
L. M. Hunnisett ◽  
P. F. Kelly ◽  
S. Bleay ◽  
F. Plasser ◽  
R. King ◽  
...  
Keyword(s):  
Mechanistic Insight ◽  
Insight Into

Mechanistic insight into hydroxylation of 2,2’,4,4’-tetrabromodiphenyl ether during biodegradation by typical aerobic bacteria: experimental and computational studies

2021 ◽  
pp. 126132
Author(s):  
Chenggang Gu ◽  
Xiuli Fan ◽  
Qingqing Ti ◽  
Xinglun Yang ◽  
Yongrong Bian ◽  
...  
Keyword(s):  
Aerobic Bacteria ◽  
Computational Studies ◽  
Mechanistic Insight ◽  
Insight Into
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