Elucidating the Neuroprotective Role of Formulated Camel α-Lactalbumin–Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson’s Disease Model

2020 ◽  
Vol 11 (24) ◽  
pp. 4416-4425
Author(s):  
Saba Ubaid ◽  
Mohammad Rumman ◽  
Babita Singh ◽  
Mohd. Sohail Akhtar ◽  
Abbas A. Mahdi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oleic Acid ◽  
Disease Model ◽  
Acid Complex

scholarly journals Protective effect of curcumin in transgenic Drosophila melanogaster model of Parkinson’s disease

2012 ◽  
Vol 2 (1) ◽  
pp. 3 ◽  
Author(s):  
Yasir Hasan Siddique ◽  
Gulshan Ara ◽  
Smita Jyoti ◽  
Mohammad Afzal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drosophila Melanogaster ◽  
Disease Model ◽  
Model Organisms ◽  
Cellular Processes ◽  
Normal Human ◽  
Climbing Ability ◽  
Dose Dependent

Studies on model organisms have been found to be invaluable in clarifying the cellular and molecular basis of normal cellular processes and disease pathogenesis. Drosophila mutants and transgenes have provided a platform to understand the mechanisms associated with degenerative disease. Studies on the role of polyphenols in protecting against neurodegenerative diseases are limited. In the present study, the effect of curcumin at various doses was studied on the climbing ability of the transgenic <em>Drosophila melanogaster </em>that expresses normal human α-synuclein in the neurons. A significant dose-dependent protection against loss of climbing ability was observed. The results suggest that curcumin can strongly improve the climbing ability of Parkinson’s disease model flies and also supports the utility of this model in studying the symptoms of Parkinson’s disease.

Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase

2004 ◽  
Vol 18 (3) ◽  
pp. 589-591 ◽  
Author(s):  
Wei Zhang ◽  
Tongguang Wang ◽  
Liya Qin ◽  
Hui‐Ming Gao ◽  
Belinda Wilson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nadph Oxidase ◽  
Neuroprotective Effect ◽  
Disease Model

scholarly journals Historical Perspective: Models of Parkinson’s Disease

2020 ◽  
Vol 21 (7) ◽  
pp. 2464 ◽  
Author(s):  
Shyh Jenn Chia ◽  
Eng-King Tan ◽  
Yin-Xia Chao
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Manipulation ◽  
Disease Model ◽  
Transgenic Models ◽  
C Elegans ◽  
Wide Range ◽  
Therapeutic Development ◽  
6 Hydroxydopamine

Parkinson’s disease (PD) is the most common movement disorder with motor and nonmotor signs. The current therapeutic regimen for PD is mainly symptomatic as the etio-pathophysiology has not been fully elucidated. A variety of animal models has been generated to study different aspects of the disease for understanding the pathogenesis and therapeutic development. The disease model can be generated through neurotoxin-based or genetic-based approaches in a wide range of animals such as non-human primates (NHP), rodents, zebrafish, Caenorhabditis (C.) elegans, and drosophila. Cellular-based disease model is frequently used because of the ease of manipulation and suitability for large-screen assays. In neurotoxin-induced models, chemicals such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, and paraquat are used to recapitulate the disease. Genetic manipulation of PD-related genes, such as α-Synuclein(SNCA), Leucine-rich repeat kinase 2 (LRRK2), Pten-Induced Kinase 1 (PINK1), Parkin(PRKN), and Protein deglycase (DJ-1) Are used in the transgenic models. An emerging model that combines both genetic- and neurotoxin-based methods has been generated to study the role of the immune system in the pathogenesis of PD. Here, we discuss the advantages and limitations of the different PD models and their utility for different research purposes.

The role of accumbens in pain modulation in the 6-OHDA induced Parkinson’s disease model

2017 ◽  
Vol 381 ◽  
pp. 1046-1047
Author(s):  
X.Q. Zhang ◽  
F. Wang ◽  
C.J. Mao ◽  
D.J. Lv ◽  
Y.P. Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Pain Modulation

scholarly journals The role of pramipexole in a severe Parkinson’s disease model in mice

2010 ◽  
Vol 3 (6) ◽  
pp. 333-337 ◽  
Author(s):  
Seham Gad ElHak ◽  
Abdel Aziz Ghanem ◽  
Hasan Abdelghaffar ◽  
Sahar ElDakroury ◽  
Dina ElTantawy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model

scholarly journals Possible therapeutic role of tetracycline derivatives in Parkinson's disease model

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S119
Author(s):  
Elaine Del Bel ◽  
Mariza Bortolanza ◽  
Glauce Nascimento ◽  
Rita Raisman-Vozari
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Therapeutic Role

A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's Disease model

2012 ◽  
Vol 46 (1) ◽  
pp. 137-146 ◽  
Author(s):  
Rafique Islam ◽  
Lichuan Yang ◽  
Megha Sah ◽  
Kavitha Kannan ◽  
Denise Anamani ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Uncoupling Protein ◽  
Disease Model ◽  
Uncoupling Protein 2

The role of anticipation and prediction in smooth pursuit in Parkinson's disease

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
J. Pohlmann ◽  
A. Sprenger ◽  
C. Helmchen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Smooth Pursuit
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