Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

Saktimayee M. Roy; Valerie L. Grum-Tokars; James P. Schavocky; Faisal Saeed; Agnieszka Staniszewski; Andrew F. Teich; Ottavio Arancio; Adam D. Bachstetter; Scott J. Webster; Linda J. Van Eldik; George Minasov; Wayne F. Anderson; Jeffrey C. Pelletier; D. Martin Watterson

doi:10.1021/acschemneuro.5b00002

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.5b00002 ◽

2015 ◽

Vol 6 (4) ◽

pp. 666-680 ◽

Cited By ~ 45

Author(s):

Saktimayee M. Roy ◽

Valerie L. Grum-Tokars ◽

James P. Schavocky ◽

Faisal Saeed ◽

Agnieszka Staniszewski ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Disease Progression ◽

Protein Kinases ◽

Mouse Models ◽

Human Central Nervous System

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Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Neurobiology of Aging ◽

10.1016/s0197-4580(88)80079-4 ◽

1988 ◽

Vol 9 ◽

pp. 339-349 ◽

Cited By ~ 422

Author(s):

Joseph Rogers ◽

Judith Luber-Narod ◽

Scot D. Styren ◽

W. Harold Civin

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Immune System ◽

Human Central Nervous System

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Gastrointestinal (GI) Tract Microbes and Microbial Neurotoxins in the Human Central Nervous System (CNS) in Alzheimer’s Disease (AD)

Journal of Alzheimer’s Disease & Parkinsonism ◽

10.4172/2161-0460.1000399 ◽

2017 ◽

Vol 07 (06) ◽

Author(s):

Yuhai Zhao ◽

Lin Cong ◽

Vivian Jaber ◽

Walter J Lukiw

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Gi Tract ◽

Human Central Nervous System

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Infrared spectra of human central nervous system tissue: Diagnosis of alzheimer's disease by multivariate analyses

Biospectroscopy ◽

10.1002/bspy.350010208 ◽

1995 ◽

Vol 1 (2) ◽

pp. 141-148 ◽

Cited By ~ 44

Author(s):

L.-P. Choo ◽

J. R. Mansfield ◽

N. Pizzi ◽

R. L. Somorjai ◽

M. Jackson ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Infrared Spectra ◽

Multivariate Analyses ◽

Central Nervous System Tissue ◽

Human Central Nervous System ◽

Tissue Diagnosis

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Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease

Journal of Neuroscience ◽

10.1523/jneurosci.16-01-00186.1996 ◽

1996 ◽

Vol 16 (1) ◽

pp. 186-199 ◽

Cited By ~ 223

Author(s):

AM Cataldo ◽

DJ Hamilton ◽

JL Barnett ◽

PA Paskevich ◽

RA Nixon

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

At Risk ◽

Central Nervous System ◽

Nervous System ◽

Human Central Nervous System ◽

Populations At Risk ◽

Lysosomal System

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P1-027: KINETIC BEHAVIOR OF NEWLY GENERATED BACE1-CLEAVED APP IN THE HUMAN CENTRAL NERVOUS SYSTEM IN ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.028 ◽

2006 ◽

Vol 14 (7S_Part_4) ◽

pp. P276-P276

Author(s):

Justyna A. Dobrowolska Zakaria ◽

Randall J. Bateman ◽

Bruce W. Patterson ◽

Robert J. Vassar

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Kinetic Behavior ◽

Human Central Nervous System

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Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease

Acta Neuropathologica ◽

10.1007/bf00293459 ◽

1991 ◽

Vol 81 (4) ◽

pp. 388-395 ◽

Cited By ~ 62

Author(s):

J. Satoh ◽

T. Tabira ◽

M. Sano ◽

H. Nakayama ◽

J. Tateishi

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Human Central Nervous System

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Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System

Journal of Molecular Neuroscience ◽

10.1007/s12031-016-0800-1 ◽

2016 ◽

Vol 60 (3) ◽

pp. 305-315 ◽

Cited By ~ 20

Author(s):

Kathryn M. Munro ◽

Amelia Nash ◽

Martina Pigoni ◽

Stefan F. Lichtenthaler ◽

Jenny M. Gunnersen

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

The Central Nervous System

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Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implications for the Treatment of Alzheimer’s Disease

Growth Factors and Alzheimer’s Disease ◽

10.1007/978-3-642-46722-6_9 ◽

1991 ◽

pp. 98-105

Author(s):

D. Lindholm ◽

F. Zafra ◽

H. Thoenen

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Nerve Growth Factor ◽

Growth Factor ◽

Nerve Growth ◽

The Central Nervous System ◽

Nerve Growth Factor Synthesis

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Central nervous system immune reactions in Alzheimer's disease

Immune Responses in the Nervous System ◽

10.1093/acprof:oso/9781872748795.003.0007 ◽

1997 ◽

pp. 143-158 ◽

Cited By ~ 1

Author(s):

Patrick L. McGeer ◽

Edith G. McGeer

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Immune Reactions

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Nerve Growth Factor (NGF) in the Central Nervous System: Implications for the Treatment of Alzheimer’s Disease

Brain Repair ◽

10.1007/978-1-349-11358-3_8 ◽

1990 ◽

pp. 99-112

Author(s):

Dan Lindholm ◽

Christine Bandtlow ◽

Matthias Spranger ◽

Bastian Hengerer ◽

Michael Meyer ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Central Nervous System ◽

Nervous System ◽

Nerve Growth Factor ◽

Growth Factor ◽

Nerve Growth ◽

The Central Nervous System

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