scholarly journals Expeditive Synthesis of Potent C20-epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells

2022 ◽  
Author(s):  
Dominika Czerwonka ◽  
Sebastian Müller ◽  
Tatiana Cañeque ◽  
Ludovic Colombeau ◽  
Adam Huczyński ◽  
...  
Keyword(s):  
Amino Derivatives ◽  
Derivatives Of

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides

2019 ◽  
Vol 19 (13) ◽  
pp. 1093-1110 ◽  
Author(s):  
Adel A.H. Abdel Rahman ◽  
Ibrahim F. Nassar ◽  
Amira K.F. Shaban ◽  
Dina S. EL-Kady ◽  
Hanem M. Awad ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Liver ◽  
Docking Studies ◽  
Cyclin Dependent Kinase ◽  
Binding Interaction ◽  
Enzyme Active Site ◽  
Human Liver Cancer ◽  
Amino Derivatives ◽  
Activity Behavior ◽  
Derivatives Of

Background & Objective:New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized.Methods:The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation.Results:The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Compounds 2a, 2b, 3a and 12 showed potent activities with IC50 results comparable to that of doxorubicin.Conclusion:Docking investigations into Cyclin-dependent kinase 2 (CDK-2) enzyme, a potential target for cancer medication, were also reported showing the possible binding interaction into the enzyme active site to support their activity behavior.

Thermal cyclocondensations of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino derivatives of 2-propenoic acid

1987 ◽  
Vol 52 (12) ◽  
pp. 2918-2925 ◽  
Author(s):  
Viktor Milata ◽  
Dušan Ilavský
Keyword(s):  
Uv Spectra ◽  
Propenoic Acid ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
C Nmr ◽  
Ir And Uv Spectra

The cyclization of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino-2-cyano- and 2-ethoxycarbonyl-2-propenoate esters Ia, b-IVa, b under the conditions of the Gould-Jacobs reaction leads to angularly ring-fused substituted imidazo or triazolo[4,5-f] (V, VI) and [4,5-h] (VII, VIII) quinolines, respectively. The esters Vb-VIIIb have been transformed into the corresponding chloroderivatives Vc-VIIIc. 3-N(5-Benzimidazolyl and 5-benztriazolyl)amino-2-cyano-2-propenenitriles are cyclized in the presence of aluminium(III) chloride to give the aminoquinolines Vd, VId. The structure of the products has been characterized by their 1H, 13C NMR, IR, and UV spectra.

ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-OXO-7-AMINO DERIVATIVES OF 5H-PYRIDO(2,3B)- AND 5H-PYRIMIDO(4,5B)(1,4)THIAZINES

1985 ◽  
Vol 16 (15) ◽  
Author(s):  
N. I. TRAVEN' ◽  
YU. A. ERSHOVA ◽  
A. S. SOKOLOVA ◽  
V. A. CHERNOV ◽  
T. S. SAFONOVA
Keyword(s):  
Antitumor Activity ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis of 4-Amino Derivatives of 5-Oxoproline

2007 ◽  
Vol 2007 (25) ◽  
pp. 4257-4266 ◽  
Author(s):  
Victor P. Krasnov ◽  
Alexey Yu. Vigorov ◽  
Irina A. Nizova ◽  
Tatyana V. Matveeva ◽  
Alexander N. Grishakov ◽  
...  
Keyword(s):  
Amino Derivatives ◽  
Derivatives Of

Preparation of new amino derivatives of the lactone tanachin and their antimicrobial activity

1996 ◽  
Vol 32 (1) ◽  
pp. 19-22
Author(s):  
M. B. Izbosarov ◽  
B. Kh. Abduazimov ◽  
M. É. Tuichieva ◽  
M. N. Yusupov ◽  
V. M. Malikov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Derivatives ◽  
Derivatives Of

scholarly journals Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

1989 ◽  
Vol 42 (11) ◽  
pp. 1673-1683 ◽  
Author(s):  
H. A. KIRST ◽  
K. E. WILLARD ◽  
M. DEBONO ◽  
J. E. TOTH ◽  
B. A. TRUEDELL ◽  
...  
Keyword(s):  
Structure Activity ◽  
Amino Derivatives ◽  
Derivatives Of

Amino derivatives of symmetric 1,3,5-triphenylbenzene. Nature of the polar singlet excited state.

1993 ◽  
Vol 176 (1) ◽  
pp. 195-213 ◽  
Author(s):  
G. Verbeek ◽  
S. Depaemelaere ◽  
M. Van der Auweraer ◽  
F.C. De Schryver ◽  
A. Vaes ◽  
...  
Keyword(s):  
Excited State ◽  
Singlet Excited State ◽  
Amino Derivatives ◽  
Derivatives Of
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