scholarly journals Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B

2021 ◽  
Author(s):  
Justin J. King ◽  
Faezeh Borzooee ◽  
Junbum Im ◽  
Mahdi Asgharpour ◽  
Atefeh Ghorbani ◽  
...  
Keyword(s):  
Small Molecule ◽  
First Generation ◽  
Small Molecule Inhibitors

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

2018 ◽  
Vol 54 (96) ◽  
pp. 13535-13538 ◽  
Author(s):  
Guoqiang Dong ◽  
Yang Liu ◽  
Ying Wu ◽  
Jie Tu ◽  
Shuqiang Chen ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Small Molecule ◽  
First Generation ◽  
Small Molecule Inhibitors ◽  
Fungal Infections ◽  
Aspartic Protease

The first-generation of small molecule SAP2 inhibitors was discovered with good antifungal potency for the treatment of resistant Candida albicans infections.

Sign in / Sign up

Export Citation Format

Share Document