Controlled Release of Proteins from Their Poly(Ethylene Glycol) Conjugates:  Drug Delivery Systems Employing 1,6-Elimination

2003 ◽  
Vol 14 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Richard B. Greenwald ◽  
Karen Yang ◽  
Hong Zhao ◽  
Charles D. Conover ◽  
Stanford Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems

2014 ◽  
Vol 469 (1) ◽  
pp. 168-178 ◽  
Author(s):  
Zhi-Yao He ◽  
Bing-Yang Chu ◽  
Xia-Wei Wei ◽  
Jiao Li ◽  
Carl K. Edwards ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Drug Delivery Systems Based on Trimethyl Lock Lactonization:  Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds

2000 ◽  
Vol 43 (3) ◽  
pp. 475-487 ◽  
Author(s):  
Richard B. Greenwald ◽  
Yun H. Choe ◽  
Charles D. Conover ◽  
Kwok Shum ◽  
Dechun Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Trimethyl Lock ◽  
Poly Ethylene

scholarly journals Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems

2021 ◽  
Vol 22 (3) ◽  
pp. 1090
Author(s):  
Daria Niewolik ◽  
Barbara Bednarczyk-Cwynar ◽  
Piotr Ruszkowski ◽  
Tomasz R. Sosnowski ◽  
Katarzyna Jaszcz
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Morphological Characteristics ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Physiological Conditions ◽  
Aerodynamic Properties ◽  
Poly Ethylene ◽  
Derivatives Of

In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol) were prepared by two-step polycondensation. These copolymers can be used as carriers in drug delivery systems, in the form of microspheres. Betulin and its derivatives exhibit a broad spectrum of biological activity, including cytotoxic activity, which makes them promising substances for use as therapeutic agents. Microspheres that were prepared from betulin based polyanhydrides show promising properties for use in application in drug delivery systems, including inhalation systems. The obtained copolymers release the active substance—betulin disuccinate—as a result of hydrolysis under physiological conditions. The use of a poly(ethylene glycol) derivative as a co-monomer increases the solubility and bioavailability of the obtained compounds. Microspheres with diameters in the range of 0.5–25 µm were prepared by emulsion solvent evaporation method and their physicochemical and aerodynamic properties were analyzed. The morphological characteristics of the microspheres depended on the presence of poly(ethylene glycol) (PEG) segment within the structure of polyanhydrides. The porosity of the particles depended on the amount and molecular weight of the PEG used and also on the speed of homogenization. The most porous particles were obtained from polyanhydrides containing 20% wt. of PEG 600 by using a homogenization speed of 18,000 rpm.

scholarly journals Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

2014 ◽  
Vol 5 (3) ◽  
pp. 799-813 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Etienne Duguet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Poly Ethylene

ChemInform Abstract: Drug Delivery Systems Based on Trimethyl Lock Lactonization: Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds.

ChemInform ◽  
2010 ◽  
Vol 31 (17) ◽  
pp. no-no
Author(s):  
Richard B. Greenwald ◽  
Yun H. Choe ◽  
Charles D. Conover ◽  
Kwok Shum ◽  
Dechun Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Trimethyl Lock ◽  
Poly Ethylene

Drug Delivery Systems Employing 1,6-Elimination:  Releasable Poly(ethylene glycol) Conjugates of Proteins

2001 ◽  
Vol 12 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Stanford Lee ◽  
Richard B. Greenwald ◽  
Jeffrey McGuire ◽  
Karen Yang ◽  
Celine Shi
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
Sign in / Sign up

Export Citation Format

Share Document