Design, synthesis and evaluation of anti-CD123 antibody drug conjugates

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.09.043 ◽

2016 ◽

Vol 24 (22) ◽

pp. 5855-5860 ◽

Author(s):

Bin Li ◽

Weiyu Zhao ◽

Xinfu Zhang ◽

Junfeng Wang ◽

Xiao Luo ◽

...

Keyword(s):

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.07.031 ◽

2019 ◽

Vol 29 (17) ◽

pp. 2455-2458

Author(s):

Emily E. Reid ◽

Katie E. Archer ◽

Manami Shizuka ◽

Molly A. McShea ◽

Erin K. Maloney ◽

...

Keyword(s):

Alkylating Agents ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

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Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues

Bioconjugate Chemistry ◽

10.1021/bc9001097 ◽

2009 ◽

Vol 20 (6) ◽

pp. 1242-1250 ◽

Author(s):

Patrick J. Burke ◽

Peter D. Senter ◽

David W. Meyer ◽

Jamie B. Miyamoto ◽

Martha Anderson ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Synthesis And Biological Evaluation ◽

Camptothecin Analogues ◽

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Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the trans ‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates

Chemistry - A European Journal ◽

10.1002/chem.202102062 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio A. W. L. Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

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Design, synthesis, and biochemical evaluation of alpha‐amanitin derivatives containing analogs of the trans‐hydroxyproline residue for potential use in antibody‐drug conjugates

Chemistry - A European Journal ◽

10.1002/chem.202101373 ◽

2021 ◽

Author(s):

Kaveh Matinkhoo ◽

Antonio AWL Wong ◽

Chido M. Hambira ◽

Brandon Kato ◽

Charlie Wei ◽

...

Keyword(s):

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Biochemical Evaluation ◽

Alpha Amanitin ◽

Potential Use ◽

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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody–Drug Conjugates, Insights into Structure–Activity Relationships, and Tubulysin–Tubulin Binding Derived from X-ray Crystallographic Analysis

The Journal of Organic Chemistry ◽

10.1021/acs.joc.0c02755 ◽

2021 ◽

Vol 86 (4) ◽

pp. 3377-3421

Author(s):

K. C. Nicolaou ◽

Saiyong Pan ◽

Kiran K. Pulukuri ◽

Qiuji Ye ◽

Stephan Rigol ◽

...

Keyword(s):

Biological Evaluation ◽

Crystallographic Analysis ◽

Design Synthesis ◽

X Ray ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Structure Activity ◽

Tubulin Binding ◽

Synthesis And Biological Evaluation ◽

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Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01385 ◽

2020 ◽

Vol 63 (22) ◽

pp. 13913-13950

Author(s):

Naidu S. Chowdari ◽

Yong Zhang ◽

Ivar McDonald ◽

Walter Johnson ◽

David R. Langley ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Structure Activity Relationships ◽

Drug Conjugates ◽

Structure Activity ◽

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Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.126782 ◽

2020 ◽

Vol 30 (1) ◽

pp. 126782 ◽

Author(s):

Yam B. Poudel ◽

Chetana Rao ◽

Srikanth Kotapati ◽

Madhura Deshpande ◽

Lourdes Thevanayagam ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Synthesis And Biological Evaluation ◽

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Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates

Journal of the American Chemical Society ◽

10.1021/jacs.7b12692 ◽

2018 ◽

Vol 140 (10) ◽

pp. 3690-3711 ◽

Author(s):

K. C. Nicolaou ◽

Rohan D. Erande ◽

Jun Yin ◽

Dionisios Vourloumis ◽

Monette Aujay ◽

...

Keyword(s):

Total Synthesis ◽

Cancer Cells ◽

Biological Evaluation ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Synthesis And Biological Evaluation ◽

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Design, Synthesis, and in vitro Evaluation of Multivalent Drug Linkers for High-Drug-Load Antibody-Drug Conjugates

ChemMedChem ◽

10.1002/cmdc.201700722 ◽

2018 ◽

Vol 13 (8) ◽

pp. 790-794 ◽

Author(s):

Bo Chen ◽

Diego A. Gianolio ◽

James E. Stefano ◽

Charlene M. Manning ◽

Richard C. Gregory ◽

...

Keyword(s):

Drug Load ◽

Design Synthesis ◽

In Vitro Evaluation ◽

High Drug ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

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ASCO-GU 2019: Metastasierte Urothelkarzinome

Onkologische Welt ◽

10.1055/a-0869-6415 ◽

2019 ◽

Vol 10 (03) ◽

pp. 140-141

Author(s):

Alexander Kretzschmar

Keyword(s):

San Francisco ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Chapel Hill ◽

Die Therapielandschaft des metastasierten Urothelkarzinoms hat sich seit der Zulassung der ersten Immun-Checkpoint-Inhibitoren verändert. Die neuen Therapien sind deutlich effektiver, allerdings erreichen die Responseraten der neuen Therapien nur bis zu etwa 30 %, beklagte Prof. Matthew Milowsky, Chapel Hill/USA, auf einer Oral Abstract Session auf dem ASCO-GU. In San Francisco gaben erste Vorträge und Poster bereits einen Einblick, wovon diejenigen Patienten profitieren könnten, die auf die etablierten Chemotherapien und die neuen Immuntherapien nicht ansprechen. Manche Onkologen sprechen bereits von der „Post-Checkpoint-Ära”. Als Kandidaten werden vor allem Antikörper-Wirkstoff-Konjugate (antibody-drug conjugates; ADC) gehandelt – und zwar nicht nur zur Therapie des metastasierten Blasenkarzinoms.

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