Transforming growth factors from a human tumor cell: characterization of transforming growth factor .beta. and identification of high molecular weight transforming growth factor .alpha.

Biochemistry ◽  
1985 ◽  
Vol 24 (21) ◽  
pp. 5925-5931 ◽  
Author(s):  
Linda L. Dart ◽  
Diane M. Smith ◽  
Chester A. Meyers ◽  
Michael B. Sporn ◽  
Charles A. Frolik
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Human Tumor ◽  
Transforming Growth Factor Alpha ◽  
Transforming Growth Factors ◽  
Human Tumor Cell ◽  
Factor Alpha ◽  
Growth Factor Beta

scholarly journals Carrageenans inhibit growth-factor binding

1993 ◽  
Vol 289 (2) ◽  
pp. 331-334 ◽  
Author(s):  
R Hoffman
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Fibroblast Growth ◽  
Tgf Beta ◽  
Factor Alpha ◽  
Growth Factor Beta ◽  
Kappa Carrageenan

Carrageenans, a family of polysulphated carbohydrates, inhibited binding of basic fibroblast growth factor (bFGF), transforming growth factor beta 1 (TGF beta 1) and platelet-derived growth factor (PDGF). iota-Carrageenan was the most potent bFGF antagonist (IC50 = 0.4 +/- 0.1 microgram/ml), kappa-carrageenan was the most potent PDGF antagonist (IC50 = 1.7 +/- 1.3 micrograms/ml) and lambda-carrageenan was the most potent TGF beta 1 antagonist (IC50 = 19 +/- 2 micrograms/ml). None of the carrageenans, at concentrations up to 200 micrograms/ml, inhibited binding of insulin-like growth factor 1 or transforming growth factor alpha. Carrageenans are selective growth-factor antagonists and have potential for the treatment of disorders associated with the over-production of certain growth factors.

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