Role of aromatic residues in the structure-function relationship of .alpha.-bungarotoxin

Biochemistry ◽  
1982 ◽  
Vol 21 (11) ◽  
pp. 2592-2600 ◽  
Author(s):  
Yee Hsiung Chen ◽  
Jang Chyi Tai ◽  
Wan Jen Huang ◽  
Ming Zong Lai ◽  
Mien Chie Hung ◽  
...  
Keyword(s):  
Structure Function ◽  
Aromatic Residues ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Alpha Bungarotoxin ◽  
Relationship Of

scholarly journals Structure-function relationship of a citrus salicylate methylesterase and role of salicylic acid in citrus canker resistance

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Caio Cesar de Lima Silva ◽  
Hugo Massayoshi Shimo ◽  
Rafael de Felício ◽  
Gustavo Fernando Mercaldi ◽  
Silvana Aparecida Rocco ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Structure Function ◽  
Citrus Canker ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

scholarly journals Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system

1983 ◽  
Vol 213 (3) ◽  
pp. 587-594 ◽  
Author(s):  
J Nandi ◽  
Z Meng-Ai ◽  
T K Ray
Keyword(s):  
Structure Function ◽  
Thiol Groups ◽  
Dye Uptake ◽  
Atpase System ◽  
Structure Function Relationship ◽  
Functional Regulation ◽  
Function Relationship ◽  
Relationship Of ◽  
Stimulation Of

The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gastric (H+ + K+)-transporting ATPase system was investigated. Two different thiol-specific agents, carboxypyridine disulphide (CPDS) and N-(1-naphthyl)maleimide (NNM) were used for the study. The structure-function relationship of the membrane thiol groups was studied after modification by the probes under various conditions, relating the inhibition of the (H+ + K+)-transporting ATPase to the ATP-dependent H+ accumulation by the gastric microsomal vesicles. On the basis of the extent of stimulation of the microsomal (H+ + K+)-transporting ATPase in the presence and absence of valinomycin (val) about 85% of the vesicles were found to be intact. CPDS at 1 mM completely inhibits the valinomycin-stimulated ATPase and the associated p-nitrophenyl phosphatase with a concomitant inhibition of vesicular H+ uptake. Both the enzyme and dye-uptake activities were fully protected against CPDS inhibition when the treatment with CPDS was carried out in the presence of ATP. ATP also offered protection (about 65%) against NNM inhibition of the (H+ + K+)-transporting ATPase system and vesicular H+ uptake. Under similar conditions ATP also protected about 10 and 6 nmol of thiol groups/mg of protein respectively from CPDS and NNM reaction. Our data suggest that the thiol groups on the outer surface of the vesicles are primarily involved in gastric (H+ + K+)-transporting ATPase function. Furthermore, at least about 15% of the total microsomal thiol groups appear to be associated with the ATPase system. The data have been discussed in terms of the structure-function relationship of gastric microsomes.

Role of Mechanical Factors in Controlling the Structure–Function Relationship of PFSA Ionomers

2012 ◽  
Vol 45 (18) ◽  
pp. 7467-7476 ◽  
Author(s):  
Ahmet Kusoglu ◽  
Suchol Savagatrup ◽  
Kyle T. Clark ◽  
Adam Z. Weber
Keyword(s):  
Structure Function ◽  
Structure Function Relationship ◽  
Mechanical Factors ◽  
Function Relationship ◽  
Relationship Of

scholarly journals Structure-Function Relationship of a Plant NCS1 Member – Homology Modeling and Mutagenesis Identified Residues Critical for Substrate Specificity of PLUTO, a Nucleobase Transporter from Arabidopsis

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91343 ◽  
Author(s):  
Sandra Witz ◽  
Pankaj Panwar ◽  
Markus Schober ◽  
Johannes Deppe ◽  
Farhan Ahmad Pasha ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Homology Modeling ◽  
Structure Function ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

Gene cloning and structure - function relationship of cytokines such as TNF and interleukins

1987 ◽  
Vol 16 (3-4) ◽  
pp. 219-226 ◽  
Author(s):  
Walter Fiers ◽  
Rudi Beyaert ◽  
Peter Brouckaert ◽  
Bart Everaerdt ◽  
Guy Haegeman ◽  
...  
Keyword(s):  
Structure Function ◽  
Gene Cloning ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

Structure-Function Relationship of Clostridial Neurotoxins

1999 ◽  
Vol 18 (1) ◽  
pp. 95-112 ◽  
Author(s):  
Li Li ◽  
Bal Ram Singh
Keyword(s):  
Structure Function ◽  
Clostridial Neurotoxins ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of
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