scholarly journals Steroid and Protein Ligand Binding to Cytochrome P450 46A1 as Assessed by Hydrogen−Deuterium Exchange and Mass Spectrometry

Biochemistry ◽  
2009 ◽  
Vol 48 (19) ◽  
pp. 4150-4158 ◽  
Author(s):  
Wei-Li Liao ◽  
Nathan G. Dodder ◽  
Natalia Mast ◽  
Irina A. Pikuleva ◽  
Illarion V. Turko
Keyword(s):  
Mass Spectrometry ◽  
Cytochrome P450 ◽  
Ligand Binding ◽  
Deuterium Exchange ◽  
Hydrogen Deuterium Exchange ◽  
Hydrogen Deuterium

scholarly journals Conservation of the conformational dynamics and ligand binding within M49 enzyme family

RSC Advances ◽  
2018 ◽  
Vol 8 (24) ◽  
pp. 13310-13322 ◽  
Author(s):  
Saša Kazazić ◽  
Zrinka Karačić ◽  
Igor Sabljić ◽  
Dejan Agić ◽  
Marko Tomin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Dynamics ◽  
Ligand Binding ◽  
Conformational Dynamics ◽  
Md Simulations ◽  
Dipeptidyl Peptidase ◽  
Deuterium Exchange ◽  
Hydrogen Deuterium Exchange ◽  
Enzyme Family ◽  
Hydrogen Deuterium

The hydrogen deuterium exchange (HDX) mass spectrometry combined with molecular dynamics (MD) simulations was employed to investigate conformational dynamics and ligand binding within the M49 family (dipeptidyl peptidase III family).

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