A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

Ari Tolonen; Miia Turpeinen; Jouko Uusitalo; Olavi Pelkonen

doi:10.1016/j.ejps.2005.02.005

A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

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Conformational Properties of the A-State of Cytochrome c Studied by Hydrogen/Deuterium Exchange and Electrospray Mass Spectrometry

Analytical Biochemistry ◽

10.1006/abio.1997.2290 ◽

1997 ◽

Vol 252 (1) ◽

pp. 127-135 ◽

Cited By ~ 9

Author(s):

Claudia S. Maier ◽

Ok-Hee Kim ◽

Max L. Deinzer

Keyword(s):

Mass Spectrometry ◽

Cytochrome C ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Conformational Properties ◽

Hydrogen Deuterium

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Screening Combinatorial Libraries of de Novo Proteins by Hydrogen−Deuterium Exchange and Electrospray Mass Spectrometry

Journal of the American Chemical Society ◽

10.1021/ja991843x ◽

1999 ◽

Vol 121 (41) ◽

pp. 9509-9513 ◽

Cited By ~ 18

Author(s):

Daniel M. Rosenbaum ◽

Sushmita Roy ◽

Michael H. Hecht

Keyword(s):

Mass Spectrometry ◽

Electrospray Mass Spectrometry ◽

De Novo ◽

Combinatorial Libraries ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

De Novo Proteins ◽

Hydrogen Deuterium

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‘On-the-fly’ hydrogen/deuterium exchange liquid chromatography/mass spectrometry using a dual-sprayer atmospheric pressure ionisation source

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2782 ◽

2006 ◽

Vol 20 (24) ◽

pp. 3769-3779 ◽

Cited By ~ 41

Author(s):

Jean-Claude Wolff ◽

Alice M.-F. Laures

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Hydrogen Deuterium

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Liquid chromatography–mass spectrometry using the hydrogen/deuterium exchange reaction as a tool for impurity identification in pharmaceutical process development

Journal of Chromatography B ◽

10.1016/j.jchromb.2005.05.039 ◽

2005 ◽

Vol 825 (2) ◽

pp. 161-168 ◽

Cited By ~ 19

Author(s):

T NOVAK ◽

R HELMY ◽

I SANTOS

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Exchange Reaction ◽

Process Development ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Hydrogen Deuterium

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Conformational Dynamics of Partially Denatured Myoglobin Studied by Time-Resolved Electrospray Mass Spectrometry with Online Hydrogen−Deuterium Exchange†,‡

Biochemistry ◽

10.1021/bi034285e ◽

2003 ◽

Vol 42 (19) ◽

pp. 5896-5905 ◽

Cited By ~ 34

Author(s):

Douglas A. Simmons ◽

Stanley D. Dunn ◽

Lars Konermann

Keyword(s):

Mass Spectrometry ◽

Electrospray Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Time Resolved ◽

Hydrogen Deuterium

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Folding Kinetics of the S100A11 Protein Dimer Studied by Time-Resolved Electrospray Mass Spectrometry and Pulsed Hydrogen−Deuterium Exchange†

Biochemistry ◽

10.1021/bi052349a ◽

2006 ◽

Vol 45 (9) ◽

pp. 3005-3013 ◽

Cited By ~ 38

Author(s):

Jingxi Pan ◽

Anne C. Rintala-Dempsey ◽

Yu Li ◽

Gary S. Shaw ◽

Lars Konermann

Keyword(s):

Mass Spectrometry ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Folding Kinetics ◽

Time Resolved ◽

Protein Dimer ◽

Hydrogen Deuterium ◽

Kinetics Of

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Dynamics of Glyphosate-Induced Conformational Changes ofMycobacterium tuberculosis5-Enolpyruvylshikimate-3-phosphate Synthase (EC 2.5.1.19) Determined by Hydrogen−Deuterium Exchange and Electrospray Mass Spectrometry†

Biochemistry ◽

10.1021/bi800134y ◽

2008 ◽

Vol 47 (28) ◽

pp. 7509-7522 ◽

Cited By ~ 16

Author(s):

Maurício R. Marques ◽

Alessandra Vaso ◽

João Ruggiero Neto ◽

Marcelo A. Fossey ◽

Jaim S. Oliveira ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

Phosphate Synthase

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Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1016/j.jasms.2005.10.009 ◽

2006 ◽

Vol 17 (2) ◽

pp. 163-167 ◽

Cited By ~ 49

Author(s):

Yan Wu ◽

John R. Engen ◽

William B. Hobbins

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Ultra Performance Liquid Chromatography ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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A triaxial probe for on-line proteolysis coupled with hydrogen/deuterium exchange-electrospray mass spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1016/j.jasms.2006.09.011 ◽

2007 ◽

Vol 18 (2) ◽

pp. 208-217 ◽

Cited By ~ 8

Author(s):

Maolian Chen ◽

Kelsey D. Cook ◽

Indu Kheterpal ◽

Ronald Wetzel

Keyword(s):

Mass Spectrometry ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

On Line

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Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3921 ◽

2009 ◽

Vol 23 (5) ◽

pp. 639-647 ◽

Cited By ~ 84

Author(s):

Stephen J. Coales ◽

Steven J. Tuske ◽

Justine C. Tomasso ◽

Yoshitomo Hamuro

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Epitope Mapping ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Amide Hydrogen ◽

Hydrogen Deuterium ◽

On Line

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