scholarly journals p90 Ribosomal S6 Kinase 2, a Novel GPCR Kinase, Is Required for Growth Factor-Mediated Attenuation of GPCR Signaling

Biochemistry ◽  
2010 ◽  
Vol 49 (12) ◽  
pp. 2657-2671 ◽  
Author(s):  
Ryan T. Strachan ◽  
John A. Allen ◽  
Douglas J. Sheffler ◽  
Bryan L. Roth
Keyword(s):  
Growth Factor ◽  
S6 Kinase ◽  
Gpcr Signaling ◽  
Ribosomal S6 Kinase 2 ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase

scholarly journals Exogenously Added Fibroblast Growth Factor 2 (FGF-2) to NIH3T3 CellsInteracts with Nuclear Ribosomal S6 Kinase 2 (RSK2) in a Cell Cycle-dependentManner*

2005 ◽  
Vol 280 (27) ◽  
pp. 25604-25610 ◽  
Author(s):  
Fabienne Soulet ◽  
Karine Bailly ◽  
Stéphane Roga ◽  
Anne-Claire Lavigne ◽  
François Amalric ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
S6 Kinase ◽  
Ribosomal S6 Kinase 2 ◽  
A Cell ◽  
Ribosomal S6 Kinase

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons

2009 ◽  
Vol 42 (2) ◽  
pp. 134-141 ◽  
Author(s):  
Matthias Fischer ◽  
Patricia Marques Pereira ◽  
Bettina Holtmann ◽  
Christian M. Simon ◽  
Andre Hanauer ◽  
...  
Keyword(s):  
Axon Growth ◽  
S6 Kinase ◽  
Ribosomal S6 Kinase 2 ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase

scholarly journals p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling

2009 ◽  
Vol 284 (22) ◽  
pp. 14939-14948 ◽  
Author(s):  
Yuki Abe ◽  
Sang-Oh Yoon ◽  
Kazuishi Kubota ◽  
Michelle C. Mendoza ◽  
Steven P. Gygi ◽  
...  
Keyword(s):  
Growth Factor ◽  
S6 Kinase ◽  
Nutrient Signaling ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase

scholarly journals p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cδ

2004 ◽  
Vol 382 (2) ◽  
pp. 425-431 ◽  
Author(s):  
Ulrik DOEHN ◽  
Steen GAMMELTOFT ◽  
Shi-Hsiang SHEN ◽  
Claus J. JENSEN
Keyword(s):  
Protein Phosphatase ◽  
Kinase Activity ◽  
Kinase Domain ◽  
Protein Kinase Activity ◽  
Dependent Manner ◽  
S6 Kinase ◽  
Ribosomal S6 Kinase 2 ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase

RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cδ (protein phosphatase 2Cδ). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity. Furthermore, PP2Cδ is phosphorylated by ERK on Thr315 and Thr333 in the catalytic domain. Mutation of Thr315 and Thr333 to alanine in a catalytically inactive mutant PP2Cδ(H154D) (His154→Asp) increases the association with RSK2 significantly, whereas mutation to glutamate, mimicking phosphorylation, reduces the binding of RSK2. The domains of interaction are mapped to the N-terminal extension comprising residues 1–71 of PP2Cδ and the N-terminal kinase domain of RSK2. The interaction is specific, since PP2Cδ associates with RSK1–RSK4, MSK1 (mitogen- and stress-activated kinase 1) and MSK2, but not with p70 S6 kinase or phosphoinositide-dependent kinase 1. We conclude that RSK2 is associated with PP2Cδ in vivo and is partially dephosphorylated by it, leading to reduced kinase activity.

scholarly journals p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling

2006 ◽  
Vol 103 (12) ◽  
pp. 4717-4722 ◽  
Author(s):  
D. J. Sheffler ◽  
W. K. Kroeze ◽  
B. G. Garcia ◽  
A. Y. Deutch ◽  
S. J. Hufeisen ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
S6 Kinase ◽  
Ribosomal S6 Kinase 2 ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase ◽  
G Protein Coupled

Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-Based Virtual Screening with the Inhibitor-Constrained Refined Homology Model

2011 ◽  
Vol 51 (11) ◽  
pp. 2939-2947 ◽  
Author(s):  
Shiliang Li ◽  
Yi Zhou ◽  
Weiqiang Lu ◽  
Ye Zhong ◽  
Wenlong Song ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Homology Model ◽  
S6 Kinase ◽  
Ribosomal S6 Kinase 2 ◽  
P90 Ribosomal S6 Kinase ◽  
Ribosomal S6 Kinase
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