The aim of this study was to investigate the friction and wear behavior of GCr15/1045 steel under different nano-particle additive conditions using a reciprocating horizontal tribometer. The results indicate that the nano-particle additives could decrease friction coefficient of CGr15/1045 steel and reduce the wear of material compared with the dry condition. Nano-particles play an important role of polishing the micro-gibbosity of contact surfaces during the friction process. The nano-particles of Ca10(PO4)6, TiO2 and TiN can form the self-repairing film on the worn surface of 1045 steel. The analysis indicates that the self-repairing effect of nano-particle of TiN is best and the self-repairing effect of nano-particle of TiO2 is worst.