scholarly journals "Responding to catalyst and specialty chemical needs is a tradition that started in 1832 for the Davison Chemical Division of W. R. Grace & Co.

1980 ◽  
Vol 58 (50) ◽  
pp. 20
Processes ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 1074
Author(s):  
Federico Zuecco ◽  
Matteo Cicciotti ◽  
Pierantonio Facco ◽  
Fabrizio Bezzo ◽  
Massimiliano Barolo

Troubleshooting batch processes at a plant-wide level requires first finding the unit causing the fault, and then understanding why the fault occurs in that unit. Whereas in the literature case studies discussing the latter issue abound, little attention has been given so far to the former, which is complex for several reasons: the processing units are often operated in a non-sequential way, with unusual series-parallel arrangements; holding vessels may be required to compensate for lack of production capacity, and reacting phenomena can occur in these vessels; and the evidence of batch abnormality may be available only from the end unit and at the end of the production cycle. We propose a structured methodology to assist the troubleshooting of plant-wide batch processes in data-rich environments where multivariate statistical techniques can be exploited. Namely, we first analyze the last unit wherein the fault manifests itself, and we then step back across the units through the process flow diagram (according to the manufacturing recipe) until the fault cannot be detected by the available field sensors any more. That enables us to isolate the unit wherefrom the fault originates. Interrogation of multivariate statistical models for that unit coupled to engineering judgement allow identifying the most likely root cause of the fault. We apply the proposed methodology to troubleshoot a complex industrial batch process that manufactures a specialty chemical, where productivity was originally limited by unexplained variability of the final product quality. Correction of the fault allowed for a significant increase in productivity.


1971 ◽  
Vol 43 (13) ◽  
pp. 21A-21A
Keyword(s):  

PEDIATRICS ◽  
1966 ◽  
Vol 38 (5) ◽  
pp. 924-924
Author(s):  
CHARLES U. LOWE ◽  
DAVID B. COURSIN ◽  
FELIX P. HEALD ◽  
ROBERT KAYE ◽  
DONOUGH O'BRIEN ◽  
...  

WITH A note of sadness, the Committee on Nutrition of the American Academy of Pediatrics wishes to call to the attention of the membership the death of Robert Ramapatnam Williams. A noted chemist and scientist, Dr. Williams obtained world renown for his work on the isolation, identification, and synthesis of vitamin B1. He died at his home in Summit, New Jersey, in October 1965. Born in Nellore, India, February 16, 1886, of American missionary parents, he began teaching in the Philippines in 1908 and considered the Islands his second home. Williams never found time to earn a doctorate, although he attended Ottawa University (Kansas) and the University of Chicago for undergraduate and postgraduate work. He earned a B.S. in 1907 and an M.S. in 1908 and received honorary LL.D. and D.Sc. degrees from numerous universities. The story of his work with beriberi is one of the most exciting in the field of nutrition. While working in the Philippines in 1910 with the Chemical Division of the Bureau of Science, he became interested in the disease. He assisted in treating an infant dying of beriberi with brown-rice bran syrup. The child's dramatic recovery stirred the synthesis of thiamine chloride. His work culminated in extensive field trials, again in the Philippines, shortly after World War I. For this study, the Bataan peninsula was divided into two parts. In the western area the inhabitants ate plain white rice; those in the eastern area received plain white rice enriched with rice coated with vitamin B1, concentrate. Within weeks the death rate from beriberi dropped dramatically in the eastern area. It remained high in the western area until smugglers began "running in" the treated rice.


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