Dual-Responsive Polymer Micelles for Target-Cell-Specific Anticancer Drug Delivery

2014 ◽  
Vol 26 (15) ◽  
pp. 4405-4418 ◽  
Author(s):  
Xing Guo ◽  
Chunli Shi ◽  
Guang Yang ◽  
Jie Wang ◽  
Zhenghong Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Target Cell ◽  
Polymer Micelles ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Responsive Polymer

Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery

2017 ◽  
Vol 60 ◽  
pp. 244-255 ◽  
Author(s):  
Jiao Guan ◽  
Zun-Qiang Zhou ◽  
Mao-Hua Chen ◽  
Hui-Yan Li ◽  
Da-Nian Tong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Target Cell ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Dual-Responsive Carbon Dots for Tumor Extracellular Microenvironment Triggered Targeting and Enhanced Anticancer Drug Delivery

2016 ◽  
Vol 8 (29) ◽  
pp. 18732-18740 ◽  
Author(s):  
Tao Feng ◽  
Xiangzhao Ai ◽  
Huimin Ong ◽  
Yanli Zhao
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Carbon Dots ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Extracellular Microenvironment

scholarly journals Prostate-Specific Membrane Antigen and Esterase Dual Responsive Camptothecin–Oligopeptide Self-Assembled Nanoparticles for Efficient Anticancer Drug Delivery

2021 ◽  
Vol Volume 16 ◽  
pp. 7959-7974
Author(s):  
Bing Xu ◽  
Mengmeng Yan ◽  
Fei Zhou ◽  
Desheng Cai ◽  
Wenbo Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Prostate Specific Membrane Antigen ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Self Assembled ◽  
Specific Membrane

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

scholarly journals Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

2014 ◽  
Vol 50 (95) ◽  
pp. 15105-15108 ◽  
Author(s):  
Yue Lu ◽  
Ran Mo ◽  
Wanyi Tai ◽  
Wujin Sun ◽  
Dennis B. Pacardo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

scholarly journals Ultrasound and pH Dually Responsive Polymer Vesicles for Anticancer Drug Delivery

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Wenqin Chen ◽  
Jianzhong Du
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Polymer Vesicles ◽  
Responsive Polymer

Hydrolytically Degradable Polymer Micelles for Anticancer Drug Delivery to Solid Tumors

2012 ◽  
Vol 213 (8) ◽  
pp. 858-867 ◽  
Author(s):  
Petr Chytil ◽  
Tomáš Etrych ◽  
Libor Kostka ◽  
Karel Ulbrich
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Anticancer Drug ◽  
Polymer Micelles ◽  
Anticancer Drug Delivery ◽  
Degradable Polymer
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