What's in a Name - Transition State or Critical Transition Structure?

1995 ◽  
Vol 72 (1) ◽  
pp. 13 ◽  
Author(s):  
S. H. Bauer ◽  
C. F. Wilcox

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180937 ◽  
Author(s):  
Bo Jin ◽  
Rui Liu ◽  
Shiying Hao ◽  
Zhen Li ◽  
Chunqing Zhu ◽  
...  


Entropy ◽  
2017 ◽  
Vol 19 (11) ◽  
pp. 584 ◽  
Author(s):  
Masa Tsuchiya ◽  
Alessandro Giuliani ◽  
Kenichi Yoshikawa


2007 ◽  
Vol 61 (11-12) ◽  
pp. 2434-2438 ◽  
Author(s):  
Yuqin Wu ◽  
Xiufang Bian ◽  
Qingge Meng ◽  
Yan Zhao ◽  
Tan Mao ◽  
...  


2017 ◽  
Author(s):  
Masa Tsuchiya ◽  
Alessandro Giuliani ◽  
Kenichi Yoshikawa

AbstractOur work dealing with the temporal development of the genome-expression profile in single-cell mouse early embryo indicated that reprogramming occurs via a critical transition state, where the critical-regulation pattern of the zygote state disappears. In this report, we unveil the detailed mechanism of how the dynamic interaction of thermodynamic states (critical states) enables the genome system to pass through the critical transition state to achieve genome reprogramming.Self-organized criticality (SOC) control of overall expression provides a snapshot of self-organization and explains the coexistence of critical states at a certain experimental time point. The time-development of self-organization is dynamically modulated by exchanges in expression flux between critical states through the cell nucleus milieu, where sequential global perturbations involving activation-inhibition of multiple critical states occur from the early state to the late 2-cell state. Two cyclic fluxes act as feedback flow and generate critical-state coherent oscillatory dynamics. Dynamic perturbation of these cyclic flows due to vivid activation of the ensemble of low-variance expression (sub-critical state) genes allows the genome system to overcome a transition state during reprogramming.Our findings imply that a universal mechanism of long-term global RNA oscillation underlies autonomous SOC control, and the critical gene ensemble at a critical point (CP) drives genome reprogramming. Unveiling the corresponding molecular players will be essential to understand single-cell reprogramming.





2019 ◽  
Vol 17 (16) ◽  
pp. 3934-3939 ◽  
Author(s):  
Joseph A. Izzo ◽  
Yaroslaw Myshchuk ◽  
Jennifer S. Hirschi ◽  
Mathew J. Vetticatt

Transition structure for the bifunctional thiourea catalyzed Michael addition using 13C KIEs and DFT calculations.



2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Fuping Zhang ◽  
Xiaoping Liu ◽  
Aidi Zhang ◽  
Zhonglin Jiang ◽  
Luonan Chen ◽  
...  


2020 ◽  
Vol 53 (12) ◽  
pp. 4855-4862 ◽  
Author(s):  
Huagao Fang ◽  
Wujin Ye ◽  
Yunsheng Ding ◽  
H. Henning Winter


2021 ◽  
Vol 33 (2) ◽  
pp. 447-452
Author(s):  
Padmanaban Kalpana ◽  
Lakshminarayanan Akilandeswari

In (Z)-1,3-pentadienes, [1,5]-H migration is suprafacially allowed while fluorine shift in this system takes place by a Contra Hoffmann antarafacial pathway for which aromaticity is the driving force. If aromaticity of the transition structure (TS) can drive a reaction towards a disallowed pathway as found in the case of fluorine, the role of aromatic ring annealed to (Z)-1,3-pentadienes in determining the reaction pathway and barrier is worth noting. Hence, the combined role of aromaticity of transition state and the loss in aromaticity of the annealed ring has been explored during the [1,5]-X (X = H, F, Cl, Br) shifts in aromatic (benzene/naphthalene) annealed 1,3-pentadiene system. Notable correlations between various aromaticity index NICS(0,1) with activation barriers show that aromaticity of transition structure in pericyclic reaction can drive the stereochemical course of a reaction. The distinct effect of fluorine to other halogens is the antara migration while the other halogens (Cl & Br) prefer supramode.



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